Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H28Cl2FNO5 |
| Molecular Weight | 476.366 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCOC(=O)[C@@]1(F)[C@@H]2C[C@@H](OCC3=CC=C(Cl)C(Cl)=C3)[C@](N)([C@H]12)C(O)=O
InChI
InChIKey=SVZJNGHWEHDHLT-OUSKECTQSA-N
InChI=1S/C22H28Cl2FNO5/c1-2-3-4-5-6-9-30-20(29)21(25)14-11-17(22(26,18(14)21)19(27)28)31-12-13-7-8-15(23)16(24)10-13/h7-8,10,14,17-18H,2-6,9,11-12,26H2,1H3,(H,27,28)/t14-,17-,18+,21-,22+/m1/s1
| Molecular Formula | C22H28Cl2FNO5 |
| Molecular Weight | 476.366 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists. | 2004-08-26 |
|
| MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity. | 2004-03 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:04:48 GMT 2025
by
admin
on
Mon Mar 31 23:04:48 GMT 2025
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| Record UNII |
12XH8EKL2A
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| Record Status |
Validated (UNII)
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12XH8EKL2A
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11641449
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820244-38-0
Created by
admin on Mon Mar 31 23:04:48 GMT 2025 , Edited by admin on Mon Mar 31 23:04:48 GMT 2025
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METABOLITE ACTIVE -> PRODRUG |
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ACTIVE MOIETY |
Actually, BCI-838 is a "prodrug." It gets converted to its active form, BCI-632, only after being metabolized in the body. BCI-632 blocks proteins in the brain known as Group II metabotropic glutamate receptors. These receptors normally bind with glutamate, a neurotransmitter that is abundant in the brain, to enable memory and other brain functions.
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