Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C28H42O |
| Molecular Weight | 394.6325 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 7 / 7 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]1(CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)C3=CC[C@]12C)[C@H](C)\C=C\[C@H](C)C(C)C
InChI
InChIKey=QSVJYFLQYMVBDR-CMNOFMQQSA-N
InChI=1S/C28H42O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-10,14,18-20,22,24-25,29H,11-13,15-17H2,1-6H3/b8-7+/t19-,20+,22-,24+,25-,27-,28+/m0/s1
| Molecular Formula | C28H42O |
| Molecular Weight | 394.6325 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 7 / 7 |
| E/Z Centers | 1 |
| Optical Activity | UNSPECIFIED |
Dehydroergosterol (DHE) is a naturally occurring, fluorescent analog of cholesterol that mimics the properties of cholesterol in cell membranes. It is readily bound by cholesterol-binding proteins and has been used for real-time probing of the sterol environment and to elucidate intracellular sterol trafficking in living organisms. Also was found, that DHE might be helpful in slowing down the deterioration in brain function by inducing a suitable microglial phenotype and might be a valuable preventive tool for dementia. DHE is considered safe to consume and is present in various dairy products, such as camembert cheese.
Approval Year
Sample Use Guides
Dehydroergosterol (DHE) at a concentration of only 2.5 μM and 5 μM suppressed TNF-α production by more than 50%. The proportion of CD11b-positive and CD206-positive M2 type microglia significantly increased after treatment with DHE. Moreover, DHE significantly suppressed the expression of I-A/I-E, CD86 and CD80, but not CD68. In particular, the expression of CD86 and CD80 in CD11b-positive microglia was markedly suppressed compared with CD11b-positive and CD206-positive microglia. DHE also significantly reduced the production of inflammatory cytokines and chemokines (TNF-α, IL-1β, MIP-1α, and IL-12p40/p70), which were highly suppressed in CD11b-positive and CD206-positive M2 type microglia.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:23:19 GMT 2023
by
admin
on
Sat Dec 16 09:23:19 GMT 2023
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| Record UNII |
123R6KJQ51
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| Record Status |
Validated (UNII)
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| Record Version |
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m4147
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516-85-8
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6436660
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123R6KJQ51
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DTXSID601026574
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admin on Sat Dec 16 09:23:19 GMT 2023 , Edited by admin on Sat Dec 16 09:23:19 GMT 2023
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