SOVATELTIDE

Investigational

Description

IRL-1620 is an endothelin-B receptor agonist with the potential neuroprotective effect. A Phase II clinical study with IRL-1620 has been initiated in patients with cerebral ischemia and mild to moderate Alzheimer’s disease.

CNS Activity

Originator

Approval Year

PubMed

PubMed

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Title	Date	PubMed
A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptor.	1992 Apr 30	1315540
Induction of endothelium-dependent relaxation in the rat aorta by IRL 1620, a novel and selective agonist at the endothelin ETB receptor.	1993 Jun	8358547
A novel neuroregenerative approach using ET(B) receptor agonist, IRL-1620, to treat CNS disorders.	2018 Jun 27	29947531

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Substance Class	Protein
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	11X778QIZS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IRL-1620

Preferred Name

English

SOVATELTIDE

Official Name

English

SPI-1620

Code

English

Sovateltide [WHO-DD]

Common Name

English

N-(3-CARBOXYPROPANOYL)-L-.ALPHA.-ASPARTYL-L-.ALPHA.-GLUTAMYL-L-.ALPHA.-GLUTAMYL-L-ALANYL-L-VALYL-L-TYROSYL-L-PHENYLALANYL-L-ALANYL-L-HISTIDYL-L-LEUCYL-L-.ALPHA.-ASPARTYL-L-ISOLEUCYL-L-ISOLEUCYL-L-TRYPTOPHAN

Systematic Name

English

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Code System

Code

Type

Description

FDA UNII

11X778QIZS

PRIMARY

SMS_ID

300000010814

PRIMARY

INN

11139

PRIMARY

DRUG BANK

DB06138

PRIMARY

NCI_THESAURUS

C74027

PRIMARY

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Subunit 0

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Related Record

Type

Details


					L5QY0GLC6X

Endothelin receptor type B

TARGET -> AGONIST

Amount:

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Related Record

Type

Details


					11X778QIZS

SOVATELTIDE

ACTIVE MOIETY

Amount:

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Structural Modifications

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Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_1]		D		N-SUCCINYL ASPARTIC ACID	32QAY14D7S

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Name	Property Type	Amount
MOL_WEIGHT:SEQUENCE(CALCULATED)	CHEMICAL	SEQUENCE 1821 DA (average)

Molecular Formula	CHEMICAL	ESTIMATED C86H116O25N18