U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
IRL-1620 is an endothelin-B receptor agonist with the potential neuroprotective effect. A Phase II clinical study with IRL-1620 has been initiated in patients with cerebral ischemia and mild to moderate Alzheimer’s disease.

Approval Year

PubMed

PubMed

TitleDatePubMed
A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptor.
1992 Apr 30
Induction of endothelium-dependent relaxation in the rat aorta by IRL 1620, a novel and selective agonist at the endothelin ETB receptor.
1993 Jun
A novel neuroregenerative approach using ET(B) receptor agonist, IRL-1620, to treat CNS disorders.
2018 Jun 27
Substance Class Protein
Created
by admin
on Sat Dec 17 17:12:53 UTC 2022
Edited
by admin
on Sat Dec 17 17:12:53 UTC 2022
Protein Sub Type
Sequence Type COMPLETE
Record UNII
11X778QIZS
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SOVATELTIDE
USAN   INN  
Official Name English
SPI-1620
Code English
N-(3-CARBOXYPROPANOYL)-L-.ALPHA.-ASPARTYL-L-.ALPHA.-GLUTAMYL-L-.ALPHA.-GLUTAMYL-L-ALANYL-L-VALYL-L-TYROSYL-L-PHENYLALANYL-L-ALANYL-L-HISTIDYL-L-LEUCYL-L-.ALPHA.-ASPARTYL-L-ISOLEUCYL-L-ISOLEUCYL-L-TRYPTOPHAN
Systematic Name English
L-TRYPTOPHAN, N-(3-CARBOXY-1-OXOPROPYL)-L-.ALPHA.-ASPARTYL-L-.ALPHA.-GLUTAMYL-L-.ALPHA.-GLUTAMYL-L-ALANYL-L-VALYL-L-TYROSYL-L-PHENYLALANYL-L-ALANYL-L-HISTIDYL-L-LEUCYL-L-.ALPHA.-ASPARTYL-L-ISOLEUCYL-L-ISOLEUCYL-
Systematic Name English
PMZ-1620
Code English
SPI 1620 [WHO-DD]
Common Name English
IRL-1620
Code English
sovateltide [INN]
Common Name English
SOVATELTIDE [USAN]
Common Name English
Code System Code Type Description
FDA UNII
11X778QIZS
Created by admin on Sat Dec 17 17:12:53 UTC 2022 , Edited by admin on Sat Dec 17 17:12:53 UTC 2022
PRIMARY
INN
11139
Created by admin on Sat Dec 17 17:12:53 UTC 2022 , Edited by admin on Sat Dec 17 17:12:53 UTC 2022
PRIMARY
DRUG BANK
DB06138
Created by admin on Sat Dec 17 17:12:53 UTC 2022 , Edited by admin on Sat Dec 17 17:12:53 UTC 2022
PRIMARY
NCI_THESAURUS
C74027
Created by admin on Sat Dec 17 17:12:53 UTC 2022 , Edited by admin on Sat Dec 17 17:12:53 UTC 2022
PRIMARY
EPA CompTox
DTXSID70162088
Created by admin on Sat Dec 17 17:12:53 UTC 2022 , Edited by admin on Sat Dec 17 17:12:53 UTC 2022
PRIMARY
CAS
142569-99-1
Created by admin on Sat Dec 17 17:12:53 UTC 2022 , Edited by admin on Sat Dec 17 17:12:53 UTC 2022
PRIMARY
USAN
HI-223
Created by admin on Sat Dec 17 17:12:53 UTC 2022 , Edited by admin on Sat Dec 17 17:12:53 UTC 2022
PRIMARY
Related Record Type Details
TARGET -> AGONIST
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:SEQUENCE(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL