SOVATELTIDE

Investigational

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67074308 | https://www.ncbi.nlm.nih.gov/pubmed/1315540 | https://www.ncbi.nlm.nih.gov/pubmed/29947531

IRL-1620 is an endothelin-B receptor agonist with the potential neuroprotective effect. A Phase II clinical study with IRL-1620 has been initiated in patients with cerebral ischemia and mild to moderate Alzheimer’s disease.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptor.	1992 Apr 30	1315540
Induction of endothelium-dependent relaxation in the rat aorta by IRL 1620, a novel and selective agonist at the endothelin ETB receptor.	1993 Jun	8358547
A novel neuroregenerative approach using ET(B) receptor agonist, IRL-1620, to treat CNS disorders.	2018 Jun 27	29947531

Substance Class	Protein Created by `admin` on `Mon Mar 31 21:23:03 GMT 2025` Edited by `admin` on `Mon Mar 31 21:23:03 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	11X778QIZS
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

IRL-1620

Preferred Name

English

SOVATELTIDE

Official Name

English

SPI-1620

Code

English

Sovateltide [WHO-DD]

Common Name

English

N-(3-CARBOXYPROPANOYL)-L-.ALPHA.-ASPARTYL-L-.ALPHA.-GLUTAMYL-L-.ALPHA.-GLUTAMYL-L-ALANYL-L-VALYL-L-TYROSYL-L-PHENYLALANYL-L-ALANYL-L-HISTIDYL-L-LEUCYL-L-.ALPHA.-ASPARTYL-L-ISOLEUCYL-L-ISOLEUCYL-L-TRYPTOPHAN

Systematic Name

English

L-TRYPTOPHAN, N-(3-CARBOXY-1-OXOPROPYL)-L-.ALPHA.-ASPARTYL-L-.ALPHA.-GLUTAMYL-L-.ALPHA.-GLUTAMYL-L-ALANYL-L-VALYL-L-TYROSYL-L-PHENYLALANYL-L-ALANYL-L-HISTIDYL-L-LEUCYL-L-.ALPHA.-ASPARTYL-L-ISOLEUCYL-L-ISOLEUCYL-

Systematic Name

English

PMZ-1620

Code

English

sovateltide [INN]

Common Name

English

SOVATELTIDE [USAN]

Common Name

English

Code System Code Type Description

FDA UNII

11X778QIZS