U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
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Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 19:55:25 GMT 2025
Edited
by admin
on Tue Apr 01 19:55:25 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
11F03GK3UH
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PYRUVATE KINASE PKR
Common Name English
PYRUVATE KINASE 1
Preferred Name English
PYRUVATE KINASE RED BLOOD CELL
Common Name English
Classification Tree Code System Code
CFR 21 CFR 862.1650
Created by admin on Tue Apr 01 19:55:25 GMT 2025 , Edited by admin on Tue Apr 01 19:55:25 GMT 2025
Code System Code Type Description
CAS
625326-52-5
Created by admin on Tue Apr 01 19:55:25 GMT 2025 , Edited by admin on Tue Apr 01 19:55:25 GMT 2025
ALTERNATIVE
WIKIPEDIA
PKLR
Created by admin on Tue Apr 01 19:55:25 GMT 2025 , Edited by admin on Tue Apr 01 19:55:25 GMT 2025
PRIMARY
EC (ENZYME CLASS)
EC 2.7.1.40
Created by admin on Tue Apr 01 19:55:25 GMT 2025 , Edited by admin on Tue Apr 01 19:55:25 GMT 2025
PRIMARY
CAS
479853-13-9
Created by admin on Tue Apr 01 19:55:25 GMT 2025 , Edited by admin on Tue Apr 01 19:55:25 GMT 2025
PRIMARY
UNIPROT
P30613
Created by admin on Tue Apr 01 19:55:25 GMT 2025 , Edited by admin on Tue Apr 01 19:55:25 GMT 2025
PRIMARY
CAS
391970-89-1
Created by admin on Tue Apr 01 19:55:25 GMT 2025 , Edited by admin on Tue Apr 01 19:55:25 GMT 2025
ALTERNATIVE
FDA UNII
11F03GK3UH
Created by admin on Tue Apr 01 19:55:25 GMT 2025 , Edited by admin on Tue Apr 01 19:55:25 GMT 2025
PRIMARY
Related Record Type Details
ACTIVATOR -> TARGET
EC50
ACTIVATOR -> TARGET
activator to 89% of activity
EC50
ACTIVATOR -> TARGET
519% activation over baseline
ALLOSTERIC
EC50

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID REPLACEMENT [1_148] [2_418] [3_418] [4_418] TYROSINE TYROSINE O-PHOSPHATE 2R86C98KDX
AMINO ACID REPLACEMENT [1_105] [1_313] [1_365] [2_105] [2_313] [2_365] [3_105] [3_313] [3_365] [4_105] [4_313] [4_365] LYSINE N6-SUCCINYLLYSINE 3LH35AJA5L
AMINO ACID REPLACEMENT [1_2] [1_19] [1_26] [1_43] [1_140] [1_292] [2_2] [2_19] [2_26] [2_43] [2_140] [2_292] [3_2] [3_19] [3_26] [3_43] [3_140] [3_292] [4_2] [4_19] [4_26] [4_43] [4_140] [4_292] SERINE DEXFOSFOSERINE VI4F0K069V
AMINO ACID REPLACEMENT [1_109] [1_365] [1_541] [2_109] [2_365] [2_541] [3_109] [3_365] [3_541] [4_109] [4_365] [4_541] LYSINE N6-SUCCINYLLYSINE 3LH35AJA5L
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL