Phosgene

Details

Stereochemistry	ACHIRAL
Molecular Formula	CCl2O
Molecular Weight	98.916
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC(Cl)=O

InChI

InChIKey=YGYAWVDWMABLBF-UHFFFAOYSA-N

InChI=1S/CCl2O/c2-1(3)4

HIDE SMILES / InChI

Molecular Formula	CCl2O
Molecular Weight	98.916
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Studies toward labeling cytisine with [11C]phosgene: rapid synthesis of a delta-lactam involving a new chemoselective lithiation-annulation method.	2004-05-28	15153010
Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells.	2004-05-12	15134338
Hypoxia and CoCl2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: a possible anti-apoptotic role for HIF-1.	2004-05-01	15093734
The metabolic rate constants and specific activity of human and rat hepatic cytochrome P-450 2E1 toward toluene and chloroform.	2004-04-09	15129551
Reactions of alpha,alpha'-dihydroxy ketones with phosgene. Structural requirements for spiro epoxy carbonate formation.	2004-03-18	15012077
Toxic inhalational injury: gas, vapor and vesicant exposure.	2004-03	15062226
Photolysis of chloral under atmospheric conditions.	2004-02-01	14968871
Effects of Cd(+2), Cu(+2), Ba(+2) and Co(+2) ions on Entamoeba histolytica cysts.	2004-02-01	14760778
Voltage-gated inward currents of morphologically identified cells of the frog taste disc.	2004-01	14752041
Trichloroethylene degradation by photocatalysis in annular flow and annulus fluidized bed photoreactors.	2004-01	14575743
Cobalt injections into the pedunculopontine nuclei attenuate the reflex diaphragmatic responses to muscle contraction in rats.	2004-01	12972440
Effect of antioxidants, oxidants, metals and saliva on cytotoxicity induction by sodium fluoride.	2003-12-12	14666669
Health hazards of welding fumes.	2003-11	14647549
Hypoxia-inducible factor-1 and activator protein-1 modulate the upregulation of CYP3A6 induced by hypoxia.	2003-11	14559859
GABA(A) receptor activation modulates corneal unit activity in rostral and caudal portions of trigeminal subnucleus caudalis.	2003-11	12890797
AMP-activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target gene expression under hypoxic conditions in DU145 cells.	2003-10-10	12900407
Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway.	2003-10-03	12855680
Debenzylation of tertiary amines using phosgene or triphosgene: an efficient and rapid procedure for the preparation of carbamoyl chlorides and unsymmetrical ureas. Application in carbon-11 chemistry.	2003-09-19	12968878
A hypoxic response induced in MatLyLu cells by cobalt chloride results in an enhanced angiogenic response by the chick chorioallantoic membrane.	2003-09	12888912
Improved reverse thermo-responsive polymeric systems.	2003-09	12818542
Ca2+ sparks are initiated by Ca2+ entry in embryonic mouse skeletal muscle and decrease in frequency postnatally.	2003-09	12724135
In vivo effect of vitamin C with cobalt on oxidative stress in experimental diabetic rat kidney.	2003-08	14768769
The cyclization transformation of the sulfonylurea herbicide flupyrsulfuron in the soil of winter wheat crops.	2003-08	12916776
Alternatives to phosgene and carbon monoxide: synthesis of symmetric urea derivatives with carbon dioxide in ionic liquids.	2003-07-21	12876737
Vascular endothelial growth factor rescues 2,3,7,8-tetrachlorodibenzo-p-dioxin inhibition of coronary vasculogenesis.	2003-07	14565620
Endothelial endostatin release is induced by general cell stress and modulated by the nitric oxide/cGMP pathway.	2003-07	12832291
Oxygen-regulated expression of the Wilms' tumor suppressor Wt1 involves hypoxia-inducible factor-1 (HIF-1).	2003-07	12738801
Identification of acidic, alkaline, and neutral sphingomyelinase activities in Mycobacterium tuberculosis.	2003-06	12824945
The temporal profile of cytokines in the bronchoalveolar lavage fluid in mice exposed to the industrial gas phosgene.	2003-06	12754690
The fate of antioxidant enzymes in bronchoalveolar lavage fluid over 7 days in mice with acute lung injury.	2003-06	12754689
Chronological changes in electrolyte levels in arterial blood and bronchoalveolar lavage fluid in mice after exposure to an edemagenic gas.	2003-06	12754688
Occupational exposure to fluorinated hydrocarbons during refrigeration repair work.	2003-04	12729261
Industrial chemicals: terrorist weapons of opportunity.	2003-04	12723117
Insulin-like growth factors-1 and -2, but not hypoxia, synergize with gonadotropin hormone to promote vascular endothelial growth factor-A secretion by monkey granulosa cells from preovulatory follicles.	2003-04	12606472
Adduction of the chloroform metabolite phosgene to lysine residues of human histone H2B.	2003-03	12641426
Catalytic carbonylation of functionalized diamines: application to the core structure of DMP 323 and DMP 450.	2003-02-21	12585919
Hypoxic activation of the atrial natriuretic peptide gene promoter through direct and indirect actions of hypoxia-inducible factor-1.	2003-02-15	12413399
Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells.	2003-02-07	12444087
Novel stereoselective synthesis of functionalized oxazolidinones from chiral aziridines.	2003-01-10	12515459
Reaction of phosgene with the tricycle related to the minor base of phenylalanine transfer ribonucleic acids.	2002-12	12499595
[Antihypoxic and antiedemic activity of new condensed indole derivatives].	2002-11-27	12449076
A safe and mild synthesis of organic carbonates from alkyl halides and tetrabutylammonium alkyl carbonates.	2002-11-15	12423173
CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2.	2002-11	12485908
Potential agents of chemical warfare. Worst-case scenario protection and decontamination methods.	2002-11	12462190
Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo.	2002-11	12376368
Synthesis and structural characterization of new stiff rod oligomeric domains by X-ray crystallography and NMR.	2002-10-18	12375986
Characterisation of the phosgene response of a membrane inlet 63Ni ion mobility spectrometer.	2002-09	12375846
Chemical and biological weapons. Implications for anaesthesia and intensive care.	2002-08	12378672
Effects of supplementation with a combination of cobalt and ascorbic acid on antioxidant enzymes and lipid peroxidation levels in streptozocin-diabetic rat liver.	2002	12666831
An 'injury-time integral' model for extrapolating from acute to chronic effects of phosgene.	2001-06	12539874

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:41:04 GMT 2025` Edited by `admin` on `Mon Mar 31 18:41:04 GMT 2025`
Record UNII	117K140075
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PHOSGEN

Preferred Name

English

Phosgene

Systematic Name

English

PHOSGENE [MART.]

Common Name

English

PHOSGENE [HSDB]

Common Name

English

CARBONYL CHLORIDE

Systematic Name

English

CARBONIC DICHLORIDE

Systematic Name

English

CARBONYL DICHLORIDE

Systematic Name

English

PHOSGENE [MI]

Common Name

English

Code System Code Type Description

MERCK INDEX

m8717