Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C24H29NO2 |
| Molecular Weight | 363.4926 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1(C)CC2=CC=CC(OCCNCC3=CC=CC(=C3)C4=CCCC4)=C2O1
InChI
InChIKey=RAIDOKRWKAIHOH-UHFFFAOYSA-N
InChI=1S/C24H29NO2/c1-24(2)16-21-11-6-12-22(23(21)27-24)26-14-13-25-17-18-7-5-10-20(15-18)19-8-3-4-9-19/h5-8,10-12,15,25H,3-4,9,13-14,16-17H2,1-2H3
| Molecular Formula | C24H29NO2 |
| Molecular Weight | 363.4926 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Towards a new generation of potential antipsychotic agents combining D2 and 5-HT1A receptor activities. | 2007 Feb 22 |
|
| Induction by antipsychotics of "win-shift" in the drug discrimination paradigm. | 2007 Jul |
|
| F15063, a potential antipsychotic with dopamine D(2)/D(3) antagonist, 5-HT(1A) agonist and D(4) partial agonist properties: (IV) duration of brain D2-like receptor occupancy and antipsychotic-like activity versus plasma concentration in mice. | 2007 Jun |
|
| F15063, a potential antipsychotic with D2/D3 antagonist, 5-HT 1A agonist and D4 partial agonist properties. I. In vitro receptor affinity and efficacy profile. | 2007 May |
|
| F15063, a compound with D2/D3 antagonist, 5-HT 1A agonist and D4 partial agonist properties. II. Activity in models of positive symptoms of schizophrenia. | 2007 May |
|
| F15063, a compound with D2/D3 antagonist, 5-HT 1A agonist and D4 partial agonist properties. III. Activity in models of cognition and negative symptoms. | 2007 May |
|
| Optimisation of anti-psychotic therapeutics: a balancing act? | 2007 May |
|
| Antipsychotics differ in their ability to internalise human dopamine D2S and human serotonin 5-HT1A receptors in HEK293 cells. | 2008 Feb 26 |
|
| The antipsychotics clozapine and olanzapine increase plasma glucose and corticosterone levels in rats: comparison with aripiprazole, ziprasidone, bifeprunox and F15063. | 2008 Sep 11 |
|
| F15063, a potential antipsychotic with dopamine D2/D3 receptor antagonist, 5-HT1A receptor agonist and dopamine D4 receptor partial agonist properties: influence on neuronal firing and neurotransmitter release. | 2009 Apr 1 |
|
| Differences among conventional, atypical and novel putative D(2)/5-HT(1A) antipsychotics on catalepsy-associated behaviour in cynomolgus monkeys. | 2009 Nov 5 |
|
| F15063, a potential antipsychotic with dopamine D(2)/D(3) receptor antagonist and 5-HT(1A) receptor agonist properties: influence on immediate-early gene expression in rat prefrontal cortex and striatum. | 2009 Oct 12 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:05:10 UTC 2023
by
admin
on
Sat Dec 16 11:05:10 UTC 2023
|
| Record UNII |
115OSL8W3F
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
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Systematic Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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DTXSID001336131
Created by
admin on Sat Dec 16 11:05:10 UTC 2023 , Edited by admin on Sat Dec 16 11:05:10 UTC 2023
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PRIMARY | |||
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10248159
Created by
admin on Sat Dec 16 11:05:10 UTC 2023 , Edited by admin on Sat Dec 16 11:05:10 UTC 2023
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680203-70-7
Created by
admin on Sat Dec 16 11:05:10 UTC 2023 , Edited by admin on Sat Dec 16 11:05:10 UTC 2023
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PRIMARY | |||
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F-15063
Created by
admin on Sat Dec 16 11:05:10 UTC 2023 , Edited by admin on Sat Dec 16 11:05:10 UTC 2023
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936029-03-7
Created by
admin on Sat Dec 16 11:05:10 UTC 2023 , Edited by admin on Sat Dec 16 11:05:10 UTC 2023
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SUPERSEDED | |||
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115OSL8W3F
Created by
admin on Sat Dec 16 11:05:10 UTC 2023 , Edited by admin on Sat Dec 16 11:05:10 UTC 2023
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PRIMARY |
| Related Record | Type | Details | ||
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