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Details

Stereochemistry ACHIRAL
Molecular Formula C2H3N3
Molecular Weight 69.0653
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 1H-1,2,4-TRIAZOLE

SMILES

N1C=NC=N1

InChI

InChIKey=NSPMIYGKQJPBQR-UHFFFAOYSA-N
InChI=1S/C2H3N3/c1-3-2-5-4-1/h1-2H,(H,3,4,5)

HIDE SMILES / InChI

Molecular Formula C2H3N3
Molecular Weight 69.0653
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
[Synthesis and antibacterial activities of 3,6-disubstituted-5,6-dihydrogen-1,2,4-s-triazolo-[3,4-b]-1,3,4-thiadiazoles].
2001 Apr
Seco C-nucleoside analogs of the 1,2,4-triazole.
2001 Apr-Jul
Synthesis and molluscicidal structure-activity relationships of some novel 1,2,4-triazole N-methyl carbamates.
2001 Aug
The 1,2,4-triazolyl cation: thermolytic and photolytic studies.
2001 Feb 23
Synthesis of 1-(3-aminopropyl)-4-phenyl-1,2,4-triazolin-5-one and 1-(3-aminopropyl)-3,4-diphenyl-1,2,4-triazolin-5-one.
2001 Jan-Feb
Expanded phthalocyanine analogues: synthesis and characterization of new triazole-derived annulenes containing six heterocyclic subunits.
2001 Jun 1
Efficient synthesis of fused isothiazolo C-nucleosides. III. Synthesis of substituted isothiazol.
2001 Mar
[Enantiomeric separations of 1-1,2,4-triazole compounds by micro-high performance liquid chromatography].
2001 May
Synthesis and antitumor activity of some new phthalimide analogues.
2001 May
An alternative route for Carboni-Lindsey reaction: N,N cycloaddition of an alkene to s-tetrazine.
2001 May 31
Syntheses of puromycin from adenosine and 7-deazapuromycin from tubercidin, and biological comparisons of the 7-aza/deaza pair.
2001 Nov 30
Traceless solid-phase synthesis of 1,2,4-triazoles using a novel amine resin.
2001 Oct 18
Determination of benzylpenicillin, oxacillin, cloxacillin, and dicloxacillin in cows' milk by ion-pair high-performance liquid chromatography after precolumn derivatization.
2001 Sep
[1,2,4]Triazole derivatives as 5-HT(1A) serotonin receptor ligands.
2002 Feb
A cis amide bond surrogate incorporating 1,2,4-triazole.
2002 May 17
Effects of sensitizers on the photodegradation of the systemic fungicide triadimenol.
2003 Apr
Synthesis and properties of new substituted 1,2,4-triazoles: potential antitumor agents.
2003 Apr 17
Different oxidation states of copper(I, I/II, II) thiocyanate complexes containing 1,2,4-triazole as a bridging ligand: syntheses, crystal structures, and magnetic properties of 2-D polymer Cu I(admtrz)SCN, linear trinuclear [CuI2CuII(admtrz)6(SCN)2](ClO4)2, and triangular trinuclear [CuII3(admtrz)4(SCN)3(mu3-OH)(H2O)](ClO4)2.H2O (admtrz = 4-amino-3,5-dimethyl-1,2,4-triazole).
2003 Jan 13
[Room-temperature solid-state synthesis of complexes of copper acetate and multi-nitrogen heterocyclic ligands].
2003 Jun
Design and synthesis of 4H-3-(2-phenoxy)phenyl-1,2,4-triazole derivatives as benzodiazepine receptor agonists.
2003 Mar 6
Synthesis of some functionalized arylaminomethyl-1 ,2,4-triazoles, 1,3,4-oxa- and thiadiazoles.
2003 Nov
Solution and solid-supported synthesis of 3,4,5-trisubstituted 1,2,4-triazole-based peptidomimetics.
2003 Nov 13
Synthesis, X-ray diffraction structures, spectroscopic properties, and in vitro antitumor activity of isomeric (1H-1,2,4-triazole)Ru(III) complexes.
2003 Sep 22
Synthesis of oligoribonucleotides containing 4-thiouridine using the convertible nucleoside approach and the 1-(2-fluorophenyl)-4-methoxypiperidin-4-yl group.
2004
Simultaneous determination of cefatrizine and clavulanic acid in dog plasma by HPLC.
2004 Apr 1
Efficient and regiospecific one-pot synthesis of substituted 1,2,4-triazoles.
2004 Aug 19
New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of "THIQ".
2004 Aug 26
Synthesis and SAR evaluation of 1,2,4-triazoles as A(2A) receptor antagonists.
2004 Feb 9
Discovery of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1h-1,2,4-triazole, a novel in vivo cannabinoid antagonist containing a 1,2,4-triazole motif.
2004 May 20
Tuning of redox potentials for the design of ruthenium anticancer drugs -- an electrochemical study of [trans-RuCl(4)L(DMSO)](-) and [trans-RuCl(4)L(2)](-) complexes, where L = imidazole, 1,2,4-triazole, indazole.
2004 Nov 1
Enzymatic resolution for the preparation of enantiomerically enriched D-beta-heterocyclic alanine derivatives using Escherichia coli aromatic L-amino acid transaminase.
2004 Nov 20
Kinetic and mechanistic study on the reaction of alkylcobaloximes with azoles.
2004 Nov 21
Highly efficient and mild copper-catalyzed N- and C-arylations with aryl bromides and iodides.
2004 Nov 5
Synthesis and antimycobacterial activity of pyridylmethylsulfanyl and naphthylmethylsulfanyl derivatives of benzazoles, 1, 2, 4-triazole, and pyridine-2-carbothioamide/-2-carbonitrile.
2004 Oct
Synthesis, antitumor and antiviral properties of some 1,2,4-triazole derivatives.
2004 Oct
Synthesis and potential antimycotic activity of 4-substituted-3-(thiophene-2-yl-methyl)-Delta2-1,2,4-triazoline-5-thiones.
2004 Sep
Synthesis and antimicrobial activities of some new 1-(5-phenylamino-[1,3,4]thiadiazol-2-yl)methyl-5-oxo-[1,2,4]triazole and 1-(4-phenyl-5-thioxo-[1,2,4]triazol-3-yl)methyl-5-oxo- [1,2,4]triazole derivatives.
2004 Sep
Mechanistic elucidation of the substitution behavior of alkyl cobaloximes in water and methanol as solvents.
2004 Sep 20
Three 1,2,4-triazole derivatives containing substituted benzyl and benzylamino groups.
2005 Feb
1-butyl-3-methylimidazolium 3,5-dinitro-1,2,4-triazolate: a novel ionic liquid containing a rigid, planar energetic anion.
2005 Feb 21
Orally active CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological activities of 1-benzazepine derivatives containing a sulfoxide moiety.
2005 Jan 17
Solid-phase synthesis of 5-amino-1-(substituted thiocarbamoyl)pyrazole and 1,2,4-triazole derivatives via dithiocarbazate linker.
2005 Jan-Feb
Phthalazine PDE IV inhibitors: conformational study of some 6-methoxy-1,4-disubstituted derivatives.
2005 Jul 15
Adaptive response of antioxidant enzymes to catalase inhibition by aminotriazole in goldfish liver and kidney.
2005 Nov
Synthesis and some first-row transition-metal complexes of the 1,2,4-triazole-based Bis(terdentate) ligands TsPMAT and PMAT.
2005 Nov 18
Tuning of redox properties for the design of ruthenium anticancer drugs: part 2. Syntheses, crystal structures, and electrochemistry of potentially antitumor [Ru III/II Cl6-n(Azole)n]z(n = 3, 4, 6) complexes.
2005 Sep 19
Influence of garlic, synthetic 1,2,4-triasole derivative and herbal preparation echinovit C on selected indices of turkey-hens non-specific immunity.
2006
Synthesis of cyclopentenyl carbocyclic nucleosides as potential antiviral agents against orthopoxviruses and SARS.
2006 Feb 9
Synthesis and CYP26A1 inhibitory activity of 1-[benzofuran-2-yl-(4-alkyl/aryl-phenyl)-methyl]-1H-triazoles.
2006 Jun 1
Differential reactivity of alpha and beta 2'-deoxyribonucleosides towards protonation and metalation.
2007 Mar
Patents
Substance Class Chemical
Created
by admin
on Thu Jul 06 00:51:36 UTC 2023
Edited
by admin
on Thu Jul 06 00:51:36 UTC 2023
Record UNII
10MS0Y1RDI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
1H-1,2,4-TRIAZOLE
HSDB   MI  
Systematic Name English
EFINACONAZOLE METABOLITE H1
Common Name English
TRIAZOLE, 1H,1,2,4-
Common Name English
PYRRODIAZOLE
Common Name English
1H-1,2,4-TRIAZOLE [MI]
Common Name English
1H-1,2,4-TRIAZOLE [HSDB]
Common Name English
NSC-83128
Code English
Classification Tree Code System Code
EPA PESTICIDE CODE 600074
Created by admin on Thu Jul 06 00:51:37 UTC 2023 , Edited by admin on Thu Jul 06 00:51:37 UTC 2023
Code System Code Type Description
PUBCHEM
9257
Created by admin on Thu Jul 06 00:51:37 UTC 2023 , Edited by admin on Thu Jul 06 00:51:37 UTC 2023
PRIMARY
NSC
83128
Created by admin on Thu Jul 06 00:51:37 UTC 2023 , Edited by admin on Thu Jul 06 00:51:37 UTC 2023
PRIMARY
MERCK INDEX
M11036
Created by admin on Thu Jul 06 00:51:37 UTC 2023 , Edited by admin on Thu Jul 06 00:51:37 UTC 2023
PRIMARY Merck Index
DRUG BANK
DB03594
Created by admin on Thu Jul 06 00:51:37 UTC 2023 , Edited by admin on Thu Jul 06 00:51:37 UTC 2023
PRIMARY
CHEBI
35550
Created by admin on Thu Jul 06 00:51:37 UTC 2023 , Edited by admin on Thu Jul 06 00:51:37 UTC 2023
PRIMARY
WIKIPEDIA
1,2,4-Triazole
Created by admin on Thu Jul 06 00:51:37 UTC 2023 , Edited by admin on Thu Jul 06 00:51:37 UTC 2023
PRIMARY
FDA UNII
10MS0Y1RDI
Created by admin on Thu Jul 06 00:51:37 UTC 2023 , Edited by admin on Thu Jul 06 00:51:37 UTC 2023
PRIMARY
ECHA (EC/EINECS)
206-022-9
Created by admin on Thu Jul 06 00:51:37 UTC 2023 , Edited by admin on Thu Jul 06 00:51:37 UTC 2023
PRIMARY
HSDB
7860
Created by admin on Thu Jul 06 00:51:37 UTC 2023 , Edited by admin on Thu Jul 06 00:51:37 UTC 2023
PRIMARY
CAS
288-88-0
Created by admin on Thu Jul 06 00:51:37 UTC 2023 , Edited by admin on Thu Jul 06 00:51:37 UTC 2023
PRIMARY
EPA CompTox
DTXSID6027131
Created by admin on Thu Jul 06 00:51:37 UTC 2023 , Edited by admin on Thu Jul 06 00:51:37 UTC 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
Related Record Type Details
PARENT -> METABOLITE
lacks pharmacologic activity
MAJOR
PARENT -> METABOLITE