MERCUDERAMIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C12H14HgNO5.HO
Molecular Weight	469.84
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[OH-].OC(C[Hg+])CNC(=O)C1=CC=CC=C1OCC(O)=O

InChI

InChIKey=PUSWWQLIFKXNQJ-UHFFFAOYSA-M

InChI=1S/C12H14NO5.Hg.H2O/c1-8(14)6-13-12(17)9-4-2-3-5-10(9)18-7-11(15)16;;/h2-5,8,14H,1,6-7H2,(H,13,17)(H,15,16);;1H2/q;+1;/p-1

HIDE SMILES / InChI

Molecular Formula	C12H14HgNO5
Molecular Weight	452.83
Charge	1
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	HO
Molecular Weight	17.0073
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://link.springer.com/book/10.1007/978-1-4757-2085-3#about | https://www.ncbi.nlm.nih.gov/pubmed/4366973 | https://www.ncbi.nlm.nih.gov/pubmed/163990

Mercuderamide is a mercurial diuretic. It inhibits both Na+-K+-ATPase and cyclic 3',5'-AMP-dependent protein kinase.

Approval Year

PubMed

Title	Date	PubMed
The effect of diuretics on Na+-K+-ATPase and c-AMP levels in toad bladder epithelial cells.	1975	163990
Inhibition by diuretics of cyclic 3',5'-AMP-dependent protein kinase from toad bladder epithelium.	1973-10	4366973

Sample Use Guides

In Vitro Use Guide

Activity of cAMP-dependent protein kinase enzyme isolated from toad bladder epithelium in the presence of 0.1 muM cAMP was significantly inhibited by 100 muM mercuderamide

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:04:13 GMT 2025` Edited by `admin` on `Mon Mar 31 18:04:13 GMT 2025`
Record UNII	1057GW1CVX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

O-((2-HYDROXY-3-(HYDROXYMERCURI)PROPYL)CARBAMOYL)PHENOXYACETIC ACID

Preferred Name

English

MERCUDERAMIDE

Official Name

English

mercuderamide [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C166443