Trastuzumab Rezetecan

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NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 07:37:48 GMT 2025` Edited by `admin` on `Wed Apr 02 07:37:48 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Type	COMPLETE
Record UNII	1000BJC8CR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SHR A1811 [WHO-DD]

Preferred Name

English

Trastuzumab Rezetecan

Official Name

English

Immunoglobulin G1, anti-(human epidermal growth factor receptor HER2) (human-Mus musculus monoclonal SHR-1805 ?1-chain), complex with human-Mus musculus monoclonal SHR-1805 ?-chain, dimer, thioether with N-[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohe

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)], humanized monoclonal antibody, conjugated via a cleavable linker with a camptot

Common Name

English

trastuzumab rezetecan [INN]

Common Name

English

Code System Code Type Description

FDA UNII

1000BJC8CR

Created by admin on Wed Apr 02 07:37:48 GMT 2025 , Edited by admin on Wed Apr 02 07:37:48 GMT 2025

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SMS_ID

300000046881

Created by admin on Wed Apr 02 07:37:48 GMT 2025 , Edited by admin on Wed Apr 02 07:37:48 GMT 2025

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NCI_THESAURUS

C178312

Created by admin on Wed Apr 02 07:37:48 GMT 2025 , Edited by admin on Wed Apr 02 07:37:48 GMT 2025

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INN

12243

Created by admin on Wed Apr 02 07:37:48 GMT 2025 , Edited by admin on Wed Apr 02 07:37:48 GMT 2025

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CAS

2647845-11-0

Created by admin on Wed Apr 02 07:37:48 GMT 2025 , Edited by admin on Wed Apr 02 07:37:48 GMT 2025

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From	To
4_134	4_194
4_23	4_88
3_134	3_194
3_23	3_88
2_370	2_428
2_264	2_324
2_147	2_203
2_22	2_96
1_370	1_428
1_264	1_324
1_147	1_203
1_22	1_96

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					1000BJC8CR

Trastuzumab Rezetecan

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_450] [2_450]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_223] [1_229] [1_232] [2_223] [2_229] [2_232] [3_214] [4_214]	SITE_SPECIFIC			UNSPECIFIED SUBSTANCE	a9e52966 (not in database)

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL

Molecular Formula	CHEMICAL