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Details

Stereochemistry ACHIRAL
Molecular Formula C6H10S3
Molecular Weight 178.339
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ALLYL TRISULFIDE

SMILES

C=CCSSSCC=C

InChI

InChIKey=UBAXRAHSPKWNCX-UHFFFAOYSA-N
InChI=1S/C6H10S3/c1-3-5-7-9-8-6-4-2/h3-4H,1-2,5-6H2

HIDE SMILES / InChI

Molecular Formula C6H10S3
Molecular Weight 178.339
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
In vitro efficacy of a compound derived from garlic against Pneumocystis carinii.
1996 Nov
In-vitro antimicrobial activity of four diallyl sulphides occurring naturally in garlic and Chinese leek oils.
2001 Jul
In vitro activity of garlic oil and four diallyl sulphides against antibiotic-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae.
2001 May
Protective effect of three diallyl sulphides against glucose-induced erythrocyte and platelet oxidation, and ADP-induced platelet aggregation.
2002 Dec 15
[Effect of allitridi on cyclin D1 and p27(Kip1) protein expression in gastric carcinoma BGC823 cells].
2003 Dec
Inhibition of cyclooxygenase-2 by diallyl sulfides (DAS) in HEK 293T cells.
2004
Experimental study on the prevention and treatment of murine cytomegalovirus hepatitis by using allitridin.
2004 Feb
Antioxidant effects of sulfur-containing amino acids.
2004 Oct 31
Diallyl trisulfide inhibits tumor necrosis factor-alpha expression in inflammed mucosa of ulcerative colitis.
2005 Aug
A case-control study in Shanghai of fruit and vegetable intake and endometrial cancer.
2005 Jun 6
Garlic arrests MDA-MB-435 cancer cells in mitosis, phosphorylates the proapoptotic BH3-only protein BimEL and induces apoptosis.
2005 May 9
Microarray analysis of altered gene expression in diallyl trisulfide-treated HepG2 cells.
2005 Nov-Dec
Effects of allitridi on cell cycle arrest of human gastric cancer cells.
2005 Sep 21
A proteomic investigation into a human gastric cancer cell line BGC823 treated with diallyl trisulfide.
2006 Jun
c-Jun NH(2)-terminal kinase signaling axis regulates diallyl trisulfide-induced generation of reactive oxygen species and cell cycle arrest in human prostate cancer cells.
2006 May 15
[Effect of diallyl trisulfide on tumor necrosis factor-alpha expression and nuclear factor-KappaB activity in mice with acute lung injury induced by lipopolysaccharide].
2007 Apr
Diallyl disulfide and diallyl trisulfide up-regulate the expression of the pi class of glutathione S-transferase via an AP-1-dependent pathway.
2007 Feb 7
Mitochondria-mediated apoptosis by diallyl trisulfide in human prostate cancer cells is associated with generation of reactive oxygen species and regulated by Bax/Bak.
2007 May
Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents.
2007 Oct
Allium compounds, dipropyl and dimethyl thiosulfinates as antiproliferative and differentiating agents of human acute myeloid leukemia cell lines.
2008 Dec
In vitro anti-Helicobacter pylori activity of diallyl sulphides and protocatechuic acid.
2008 Jan
Transcriptional repression and inhibition of nuclear translocation of androgen receptor by diallyl trisulfide in human prostate cancer cells.
2009 Aug 1
Diallyl trisulphide-induced apoptosis in human melanoma cells involves downregulation of Bcl-2 and Bcl-xL expression and activation of caspases.
2009 Dec
Neuroprotective potential of phase II enzyme inducer diallyl trisulfide.
2009 Feb
[Role of allitridin in the blocking of murine cytomegalovirus induced regulatory T cells amplification in vitro].
2010 Jul 27
Sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxification enzymes in rat hepatoma H4IIE cells.
2010 Jun
Diallylpolysulfides induce growth arrest and apoptosis.
2010 Mar
Sulforaphane and alpha-lipoic acid upregulate the expression of the pi class of glutathione S-transferase through c-jun and Nrf2 activation.
2010 May
Diallyl disulfide and diallyl trisulfide protect endothelial nitric oxide synthase against damage by oxidized low-density lipoprotein.
2010 May
Study on the effects of allitride and its mechanisms on renal cell carcinoma in vitro.
2011 Apr-Jun
Garlic constituent diallyl trisulfide suppresses x-linked inhibitor of apoptosis protein in prostate cancer cells in culture and in vivo.
2011 Jun
Diallyl trisulfide suppresses the adipogenesis of 3T3-L1 preadipocytes through ERK activation.
2012 Mar
Diallyl sulfide, diallyl disulfide and diallyl trisulfide affect drug resistant gene expression in colo 205 human colon cancer cells in vitro and in vivo.
2012 May 15
Effect of diallyl trisulfide on human ovarian cancer SKOV- 3/DDP cell apoptosis.
2013
Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of osteosarcoma cells by switching on suppressor microRNAs and inactivating of Notch-1 signaling.
2013 Jul
Inhibiting invasion into human bladder carcinoma 5637 cells with diallyl trisulfide by inhibiting matrix metalloproteinase activities and tightening tight junctions.
2013 Oct 1
Diallyl sulfide, diallyl disulfide, and diallyl trisulfide inhibit migration and invasion in human colon cancer colo 205 cells through the inhibition of matrix metalloproteinase-2, -7, and -9 expressions.
2013 Sep
Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes.
2013 Sep 30
Allitridin reduces I Kr current by disrupting the trafficking of human ether-à-go-go-related gene channels.
2014
Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation.
2014
Apoptotic pathway induced by diallyl trisulfide in pancreatic cancer cells.
2014 Jan 7
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:52:04 GMT 2023
Edited
by admin
on Fri Dec 15 17:52:04 GMT 2023
Record UNII
0ZO1U5A3XX
Record Status Validated (UNII)
Record Version
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Name Type Language
ALLYL TRISULFIDE
Systematic Name English
ALLITRIDE
Common Name English
Diallyl trisulfide [WHO-DD]
Common Name English
DIALLYL TRISULPHIDE
Systematic Name English
ALLITRIDUM
Common Name English
DIALLYL TRISULFIDE [MI]
Common Name English
DIALLYL TRISULFIDE
FHFI   MI  
Systematic Name English
DIALLYL TRISULFIDE [FHFI]
Common Name English
FEMA NO. 3265
Code English
DI-2-PROPENYL TRISULFIDE
Systematic Name English
NSC-651936
Code English
TRISULFIDE, DI-2-PROPENYL
Systematic Name English
ALLITRIDIN
Common Name English
Classification Tree Code System Code
JECFA EVALUATION DIALLYL TRISULFIDE
Created by admin on Fri Dec 15 17:52:04 GMT 2023 , Edited by admin on Fri Dec 15 17:52:04 GMT 2023
NCI_THESAURUS C68520
Created by admin on Fri Dec 15 17:52:04 GMT 2023 , Edited by admin on Fri Dec 15 17:52:04 GMT 2023
Code System Code Type Description
CHEBI
78492
Created by admin on Fri Dec 15 17:52:04 GMT 2023 , Edited by admin on Fri Dec 15 17:52:04 GMT 2023
PRIMARY
PUBCHEM
16315
Created by admin on Fri Dec 15 17:52:04 GMT 2023 , Edited by admin on Fri Dec 15 17:52:04 GMT 2023
PRIMARY
MERCK INDEX
m4246
Created by admin on Fri Dec 15 17:52:04 GMT 2023 , Edited by admin on Fri Dec 15 17:52:04 GMT 2023
PRIMARY Merck Index
NCI_THESAURUS
C68525
Created by admin on Fri Dec 15 17:52:04 GMT 2023 , Edited by admin on Fri Dec 15 17:52:04 GMT 2023
PRIMARY
CAS
2050-87-5
Created by admin on Fri Dec 15 17:52:04 GMT 2023 , Edited by admin on Fri Dec 15 17:52:04 GMT 2023
PRIMARY
MESH
C042577
Created by admin on Fri Dec 15 17:52:04 GMT 2023 , Edited by admin on Fri Dec 15 17:52:04 GMT 2023
PRIMARY
FDA UNII
0ZO1U5A3XX
Created by admin on Fri Dec 15 17:52:04 GMT 2023 , Edited by admin on Fri Dec 15 17:52:04 GMT 2023
PRIMARY
EPA CompTox
DTXSID9045972
Created by admin on Fri Dec 15 17:52:04 GMT 2023 , Edited by admin on Fri Dec 15 17:52:04 GMT 2023
PRIMARY
JECFA MONOGRAPH
153
Created by admin on Fri Dec 15 17:52:04 GMT 2023 , Edited by admin on Fri Dec 15 17:52:04 GMT 2023
PRIMARY
ECHA (EC/EINECS)
218-107-8
Created by admin on Fri Dec 15 17:52:04 GMT 2023 , Edited by admin on Fri Dec 15 17:52:04 GMT 2023
PRIMARY
NSC
651936
Created by admin on Fri Dec 15 17:52:04 GMT 2023 , Edited by admin on Fri Dec 15 17:52:04 GMT 2023
PRIMARY
WIKIPEDIA
Diallyl trisulfide
Created by admin on Fri Dec 15 17:52:04 GMT 2023 , Edited by admin on Fri Dec 15 17:52:04 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> POSSIBLE ACTIVE CONSTITUENT ALWAYS PRESENT