Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H5Cl5 |
| Molecular Weight | 326.433 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC(=C(Cl)C=C1)C2=C(Cl)C(Cl)=CC=C2Cl
InChI
InChIKey=GXNNLIMMEXHBKV-UHFFFAOYSA-N
InChI=1S/C12H5Cl5/c13-6-1-2-8(14)7(5-6)11-9(15)3-4-10(16)12(11)17/h1-5H
| Molecular Formula | C12H5Cl5 |
| Molecular Weight | 326.433 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat. | 2015-12-02 |
|
| Resveratrol via sirtuin-1 downregulates RE1-silencing transcription factor (REST) expression preventing PCB-95-induced neuronal cell death. | 2015-11-01 |
|
| Detection and measurement of the agonistic activities of PCBs and mono-hydroxylated PCBs to the constitutive androstane receptor using a recombinant yeast assay. | 2015-10 |
|
| Structure-activity relationship of selected meta- and para-hydroxylated non-dioxin like polychlorinated biphenyls: from single RyR1 channels to muscle dysfunction. | 2013-12 |
|
| Sexually dimorphic behavior after developmental exposure to characterize endocrine-mediated effects of different non-dioxin-like PCBs in rats. | 2013-09-06 |
|
| PCB-95 modulates the calcium-dependent signaling pathway responsible for activity-dependent dendritic growth. | 2012-07 |
|
| PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms. | 2012-07 |
|
| Some OH-PCBs are more potent inhibitors of aromatase activity and (anti-) glucocorticoids than non-dioxin like (NDL)-PCBs and MeSO₂-PCBs. | 2011-10-10 |
|
| In vitro toxicity profiling of ultrapure non-dioxin-like polychlorinated biphenyl congeners and their relative toxic contribution to PCB mixtures in humans. | 2011-05 |
|
| Activation and potentiation of human GABAA receptors by non-dioxin-like PCBs depends on chlorination pattern. | 2010-11 |
|
| Differential effects of polychlorinated biphenyl congeners on serum thyroid hormone levels in rats. | 2010-09 |
|
| Non-dioxin-like-PCBs phosphorylate Mdm2 at Ser166 and attenuate the p53 response in HepG2 cells. | 2009-12-10 |
|
| Excitatory and inhibitory synaptic transmission is differentially influenced by two ortho-substituted polychlorinated biphenyls in the hippocampal slice preparation. | 2009-06-01 |
|
| Coordinated movement of cytoplasmic and transmembrane domains of RyR1 upon gating. | 2009-04-14 |
|
| Ryanodine receptor type 1 (RyR1) possessing malignant hyperthermia mutation R615C exhibits heightened sensitivity to dysregulation by non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95). | 2007-07 |
|
| Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1). | 2006-01 |
|
| Coplanar polychlorinated biphenyls activate the aryl hydrocarbon receptor in developing tissues of two TCDD-responsive lacZ mouse lines. | 2005-10 |
|
| Non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95) amplifies ionotropic glutamate receptor signaling in embryonic cerebellar granule neurons by a mechanism involving ryanodine receptors. | 2004-01 |
|
| Ortho-substituted polychlorinated biphenyl (PCB) congeners (95 or 101) decrease pituitary response to thyrotropin releasing hormone. | 2003-09-30 |
|
| Foci formation of MCF7 cells as an in vitro screening method for estrogenic chemicals. | 2002-03 |
|
| The hypothalamo-pituitary-thyroid (HPT) axis: a target of nonpersistent ortho-substituted PCB congeners. | 2002-01 |
|
| ortho-substituted PCB95 alters intracellular calcium signaling and causes cellular acidification in PC12 cells by an immunophilin-dependent mechanism. | 2001-01 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:17:11 GMT 2025
by
admin
on
Mon Mar 31 21:17:11 GMT 2025
|
| Record UNII |
0YO8J06WCR
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| Record Status |
Validated (UNII)
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| Record Version |
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