ISOXAPROLOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H26N2O3
Molecular Weight	330.4213
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=NOC(\C=C\C2=CC=CC=C2OCC(O)CNC(C)(C)C)=C1

InChI

InChIKey=MOIVIHVEHZGRGG-MDZDMXLPSA-N

InChI=1S/C19H26N2O3/c1-14-11-17(24-21-14)10-9-15-7-5-6-8-18(15)23-13-16(22)12-20-19(2,3)4/h5-11,16,20,22H,12-13H2,1-4H3/b10-9+

HIDE SMILES / InChI

Molecular Formula	C19H26N2O3
Molecular Weight	330.4213
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	1
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67018658 | https://www.ncbi.nlm.nih.gov/pubmed/6118439

ISOXAPROLOL is a potent beta-adrenoceptor antagonist with antihypertensive properties. It was effective in lowering blood pressure in acute trials on spontaneously hypertensive rats at a dosage of 15 mg/kg.

Approval Year

PubMed

Title	Date	PubMed
2-(Isoxazolylethenyl)phenoxypropanolamines: a new class of beta-receptor antagonists with antihypertensive activity.	1981 Dec	6118439

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:26:23 GMT 2023` Edited by `admin` on `Fri Dec 15 16:26:23 GMT 2023`
Record UNII	0Y84EU1HAA
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ISOXAPROLOL

Official Name

English

(±)-(E)-1-(TERT-BUTYLAMINO)-3-(O-(2-(3-METHYL-5-ISOXAZOLYL)VINYL)PHENOXY)-2-PROPANOL

Common Name

English

isoxaprolol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C319