U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 00:46:56 GMT 2025
Edited
by admin
on Wed Apr 02 00:46:56 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
0XMR8L9LOL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MEZAGITAMAB
USAN   INN  
Official Name English
IMMUNOGLOBULIN G1, ANTI-(HUMAN CD38 ANTIGEN) (HUMAN MONOCLONAL AB79 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL AB79 .LAMBDA.-CHAIN, DIMER
Preferred Name English
TAK079
Code English
mezagitamab [INN]
Common Name English
Mezagitamab [WHO-DD]
Common Name English
HUMAN IGG1 ANTI CD38 MONOCLONAL ANTIBODY TAK-079
Common Name English
TAK-079
Code English
MEZAGITAMAB [USAN]
Common Name English
IMMUNOGLOBULIN G1-LAMBDA, ANTI-(HOMO SAPIENS ADP-RIBOSYL CYCLASE/CYCLIC ADP-RIBOSE HYDROLASE 1 (2'-PHOSPHO-ADP-RIBOSYL CYCLASE, ANTIGENE CD38))HUMANIZED MONOCLONAL ANTIBODY.GAMMA.1 HEAVY CHAIN HUMANIZED(1-453) (HOMO SAPIENS VH (IGHV3-23*01 (89%) (IGHD)-I
Common Name English
ANTI-CD38 MONOCLONAL ANTIBODY TAK-079
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 667418
Created by admin on Wed Apr 02 00:46:56 GMT 2025 , Edited by admin on Wed Apr 02 00:46:56 GMT 2025
FDA ORPHAN DRUG 905822
Created by admin on Wed Apr 02 00:46:56 GMT 2025 , Edited by admin on Wed Apr 02 00:46:56 GMT 2025
Code System Code Type Description
USAN
HI-208
Created by admin on Wed Apr 02 00:46:56 GMT 2025 , Edited by admin on Wed Apr 02 00:46:56 GMT 2025
PRIMARY
NCI_THESAURUS
C148078
Created by admin on Wed Apr 02 00:46:56 GMT 2025 , Edited by admin on Wed Apr 02 00:46:56 GMT 2025
PRIMARY
SMS_ID
300000010802
Created by admin on Wed Apr 02 00:46:56 GMT 2025 , Edited by admin on Wed Apr 02 00:46:56 GMT 2025
PRIMARY
CAS
2227490-52-8
Created by admin on Wed Apr 02 00:46:56 GMT 2025 , Edited by admin on Wed Apr 02 00:46:56 GMT 2025
PRIMARY
FDA UNII
0XMR8L9LOL
Created by admin on Wed Apr 02 00:46:56 GMT 2025 , Edited by admin on Wed Apr 02 00:46:56 GMT 2025
PRIMARY
INN
11159
Created by admin on Wed Apr 02 00:46:56 GMT 2025 , Edited by admin on Wed Apr 02 00:46:56 GMT 2025
PRIMARY
From To
1_22 1_96
2_22 2_96
2_150 2_206
2_226 4_215
2_267 2_327
1_150 1_206
2_373 2_431
3_22 3_89
3_138 3_197
4_22 4_89
4_138 4_197
1_226 3_215
1_232 2_232
1_235 2_235
1_267 1_327
1_373 1_431
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_303
N 2_303
Related Record Type Details
ADP-RIBOSYL CYCLASE/CYCLIC ADP-RIBOSE HYDROLASE 1
TARGET -> INHIBITOR
depletes human tumor cells expressing CD38 by antibody-dependent cellular cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC).
Related Record Type Details
MEZAGITAMAB
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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