Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C21H24N2O4.ClH |
Molecular Weight | 404.887 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.COC1=CC=C(C[C@@H](C)NC[C@H](O)C2=CC=C(O)C3=C2C=CC(=O)N3)C=C1
InChI
InChIKey=SYCWERNQGSKYAG-QVRIGTRMSA-N
InChI=1S/C21H24N2O4.ClH/c1-13(11-14-3-5-15(27-2)6-4-14)22-12-19(25)16-7-9-18(24)21-17(16)8-10-20(26)23-21;/h3-10,13,19,22,24-25H,11-12H2,1-2H3,(H,23,26);1H/t13-,19+;/m1./s1
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C21H24N2O4 |
Molecular Weight | 368.4263 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Carmoterol is a long-acting β2-adrenoceptor agonist with a rapid onset of action and potent bronchodilating activity. Carmoterol has a similar onset of action compared to salbutamol and formoterol, and a faster onset of action compared to salmeterol. Furthermore, the duration of tracheal smooth muscle relaxation is longer for carmoterol compared to both formoterol and salmeterol. In asthmatic patients, the PK of carmoterol is proportional to the dose, and nonlinear accumulation of the drug after repeated dosing treatments is negligible. In patients with persistent asthma carmoterol 2 µg administered once daily is as effective as formoterol 12 µg twice daily. Safety and tolerability results are similar between carmoterol and formoterol. There were no significant changes in ECG results, blood pressure or serum potassium or glucose levels
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL210 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20402514 |
3.19 nM [Ki] |
Sample Use Guides
In Vivo Use Guide
Sources: Kanniess F, Make BJ, Petruzzelli S. Acute effect of carmoterol, a long-acting β2-agonist, in patients with COPD [abstract] Proc Am Thorac Soc. 2008;5:A655. https://www.ncbi.nlm.nih.gov/pubmed/21232045
4 µg of 2 µg
Route of Administration:
Respiratory
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:04:46 GMT 2023
by
admin
on
Fri Dec 15 16:04:46 GMT 2023
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Record UNII |
0WLO9P0V75
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Record Status |
Validated (UNII)
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Record Version |
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-
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0WLO9P0V75
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63951
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C074413
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137888-11-0
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admin on Fri Dec 15 16:04:46 GMT 2023 , Edited by admin on Fri Dec 15 16:04:46 GMT 2023
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Related Record | Type | Details | ||
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