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Details

Stereochemistry ABSOLUTE
Molecular Formula 3C18H34O2.2C6H14O6
Molecular Weight 1211.7302
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 3
Charge 0

SHOW SMILES / InChI
Structure of SORBITAN SESQUIOLEATE

SMILES

CCCCCCCC/C(/[H])=C(/[H])\CCCCCCCC(=O)O.CCCCCCCC/C(/[H])=C(/[H])\CCCCCCCC(=O)O.CCCCCCCC/C(/[H])=C(/[H])\CCCCCCCC(=O)O.C([C@]([H])([C@]([H])([C@@]([H])([C@]([H])(CO)O)O)O)O)O.C([C@]([H])([C@]([H])([C@@]([H])([C@]([H])(CO)O)O)O)O)O

InChI

InChIKey=CUNWUEBNSZSNRX-RKGWDQTMSA-N
InChI=1S/3C18H34O2.2C6H14O6/c3*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;2*7-1-3(9)5(11)6(12)4(10)2-8/h3*9-10H,2-8,11-17H2,1H3,(H,19,20);2*3-12H,1-2H2/b3*10-9-;;/t;;;2*3-,4+,5-,6-/m...11/s1

HIDE SMILES / InChI

Molecular Formula C18H34O2
Molecular Weight 282.462
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Molecular Formula C6H14O6
Molecular Weight 182.172
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

A sorbitol derivative emulsifier used in many topical agents. Sorbitan Sesquioleate is used in a variety of products including skin care products, skin cleansing products, moisturizers, eye makeup and other makeup, primarily as an emollient. It is added to formulas as a skin soother and moisturizer and is derived from sorbitol, a humectant. Sorbitol sesquioleate (SSO) have recently been implicated in allergic dermatitis.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
Clobetasol propionate ointment

Approved Use

Clobetasol propionate cream and ointment are super-high potency corticosteroid formulations indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses. Treatment beyond 2 consecutive weeks is not recommended, and the total dosage should not exceed 50 g per week because of the potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis. Use in children under 12 years of age is not recommended.

Launch Date

8.371296E11
PubMed

PubMed

TitleDatePubMed
Drug distribution in enteric microparticles.
2009 Sep 8
Contact allergy to sorbitans: a follow-up study.
2012 Jul-Aug
Allergic contact dermatitis caused by sorbitan sesquioleate imitating severe glove dermatitis in a patient with filaggrin mutation.
2013 Nov
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Jun 25 21:19:58 UTC 2021
Edited
by admin
on Fri Jun 25 21:19:58 UTC 2021
Record UNII
0W8RRI5W5A
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SORBITAN SESQUIOLEATE
EP   II   INCI   INN   MART.   USAN   VANDF   WHO-DD  
INN   USAN   INCI  
Official Name English
SORBITAN SESQUIOLEATE [EP]
Common Name English
SORBITAN SESQUIOLEATE [USAN]
Common Name English
SORBITAN SESQUIOLEATE [VANDF]
Common Name English
SORBITAN SESQUIOLEATE [INCI]
Common Name English
SORBITAN SESQUIOLEATE [EP MONOGRAPH]
Common Name English
SORBITAN SESQUIOLEATE [WHO-DD]
Common Name English
SORBITAN SESQUIOLEATE [MART.]
Common Name English
SORBITAN SESQUIOLEATE [II]
Common Name English
SORBITAN SESQUIOLEATE [JAN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C83486
Created by admin on Fri Jun 25 21:19:58 UTC 2021 , Edited by admin on Fri Jun 25 21:19:58 UTC 2021
Code System Code Type Description
NCI_THESAURUS
C152407
Created by admin on Fri Jun 25 21:19:58 UTC 2021 , Edited by admin on Fri Jun 25 21:19:58 UTC 2021
PRIMARY
CAS
8007-43-0
Created by admin on Fri Jun 25 21:19:58 UTC 2021 , Edited by admin on Fri Jun 25 21:19:58 UTC 2021
PRIMARY
MESH
C058854
Created by admin on Fri Jun 25 21:19:58 UTC 2021 , Edited by admin on Fri Jun 25 21:19:58 UTC 2021
PRIMARY
FDA UNII
0W8RRI5W5A
Created by admin on Fri Jun 25 21:19:58 UTC 2021 , Edited by admin on Fri Jun 25 21:19:58 UTC 2021
PRIMARY
RXCUI
1363058
Created by admin on Fri Jun 25 21:19:58 UTC 2021 , Edited by admin on Fri Jun 25 21:19:58 UTC 2021
PRIMARY RxNorm
INN
1877
Created by admin on Fri Jun 25 21:19:58 UTC 2021 , Edited by admin on Fri Jun 25 21:19:58 UTC 2021
PRIMARY
EPA CompTox
8007-43-0
Created by admin on Fri Jun 25 21:19:58 UTC 2021 , Edited by admin on Fri Jun 25 21:19:58 UTC 2021
PRIMARY
ECHA (EC/EINECS)
232-360-1
Created by admin on Fri Jun 25 21:19:58 UTC 2021 , Edited by admin on Fri Jun 25 21:19:58 UTC 2021
PRIMARY
EVMPD
SUB10600MIG
Created by admin on Fri Jun 25 21:19:58 UTC 2021 , Edited by admin on Fri Jun 25 21:19:58 UTC 2021
PRIMARY
PUBCHEM
6433515
Created by admin on Fri Jun 25 21:19:58 UTC 2021 , Edited by admin on Fri Jun 25 21:19:58 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE