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Details

Stereochemistry RACEMIC
Molecular Formula C12H10ClN3O.ClH
Molecular Weight 284.141
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZONICLEZOLE HYDROCHLORIDE

SMILES

Cl.CC(N1C=CN=C1)C2=NOC3=C2C=C(Cl)C=C3

InChI

InChIKey=XGQRATAWGQQGRW-UHFFFAOYSA-N
InChI=1S/C12H10ClN3O.ClH/c1-8(16-5-4-14-7-16)12-10-6-9(13)2-3-11(10)17-15-12;/h2-8H,1H3;1H

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C12H10ClN3O
Molecular Weight 247.68
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Zoniclezole was proven to have anticonvulsant profile. It is representative of a novel class of water-soluble agents being developed for the treatment of epilepsy. Zoniclezole has been shown to be a potential antagonist of electroshock-induced seizures in animals, and to some degree, pentylenetetrazol-induced seizures. In preclinical studies the compound had prolonged efficacy at relatively low doses. Zoniclezole is glutamate receptor antagonist.

Approval Year

Patents

Patents

Substance Class Chemical
Created
by admin
on Fri Dec 15 15:46:52 GMT 2023
Edited
by admin
on Fri Dec 15 15:46:52 GMT 2023
Record UNII
0VM256HNOM
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ZONICLEZOLE HYDROCHLORIDE
USAN  
USAN  
Official Name English
ZONICLEZOLE HYDROCHLORIDE [USAN]
Common Name English
1,2-BENZISOXAZOLE, 5-CHLORO-3-(1-(1H-IMIDAZOL-1-YL)ETHYL)-, MONOHYDROCHLORIDE
Common Name English
ZONICLEZOLE HCL
Common Name English
5-Chloro-3-(1-imidazol-1-ylethyl)-1,2-benzisoxazole monohydrochloride
Systematic Name English
CGS-18416A
Code English
CGS 18416A
Code English
Classification Tree Code System Code
NCI_THESAURUS C264
Created by admin on Fri Dec 15 15:46:52 GMT 2023 , Edited by admin on Fri Dec 15 15:46:52 GMT 2023
Code System Code Type Description
PUBCHEM
10221449
Created by admin on Fri Dec 15 15:46:52 GMT 2023 , Edited by admin on Fri Dec 15 15:46:52 GMT 2023
PRIMARY
NCI_THESAURUS
C82236
Created by admin on Fri Dec 15 15:46:52 GMT 2023 , Edited by admin on Fri Dec 15 15:46:52 GMT 2023
PRIMARY
ChEMBL
CHEMBL2111150
Created by admin on Fri Dec 15 15:46:52 GMT 2023 , Edited by admin on Fri Dec 15 15:46:52 GMT 2023
PRIMARY
USAN
CC-43
Created by admin on Fri Dec 15 15:46:52 GMT 2023 , Edited by admin on Fri Dec 15 15:46:52 GMT 2023
PRIMARY
CAS
121929-46-2
Created by admin on Fri Dec 15 15:46:52 GMT 2023 , Edited by admin on Fri Dec 15 15:46:52 GMT 2023
PRIMARY
FDA UNII
0VM256HNOM
Created by admin on Fri Dec 15 15:46:52 GMT 2023 , Edited by admin on Fri Dec 15 15:46:52 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY