CLOFURAC

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H15ClO2
Molecular Weight	250.721
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=CC2=C(OC(=O)C2)C=C1C3CCCCC3

InChI

InChIKey=FFPGKSCPXZYKFO-UHFFFAOYSA-N

InChI=1S/C14H15ClO2/c15-12-6-10-7-14(16)17-13(10)8-11(12)9-4-2-1-3-5-9/h6,8-9H,1-5,7H2

HIDE SMILES / InChI

Molecular Formula	C14H15ClO2
Molecular Weight	250.721
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7332706

Clofurac is an anti-inflammatory compound synthesized by Sandoz in the 1980s. In animal models, clofurac inhibited the acute inflammation induced by carrageenin, was more effective in adjuvant-induced arthritis than diclofenac, and inhibited PGE2 and PGF2a synthesis in vitro. The compound was found to be strongly ulcerogenic in the rat.

Approval Year

PubMed

Title	Date	PubMed
2,3-Dihydrobenzofuran-2-ones: a new class of highly potent antiinflammatory agents.	1981 Dec	7332706

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:03:59 GMT 2023` Edited by `admin` on `Fri Dec 15 16:03:59 GMT 2023`
Record UNII	0V7WAB3NV4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLOFURAC

Official Name

English

clofurac [INN]

Common Name

English

5-CHLORO-6-CYCLOHEXYL-2(3H)-BENZOFURANONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257