Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | O2 |
| Molecular Weight | 31.9988 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | -1 |
SHOW SMILES / InChI
SMILES
O=[O-]
InChI
InChIKey=MXDZWXWHPVATGF-UHFFFAOYSA-N
InChI=1S/O2/c1-2/q-1
| Molecular Formula | O2 |
| Molecular Weight | 31.9988 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Oxygen is a chemical element with atomic number 8. Diatomic oxygen constitutes 20.8% of the Earth's atmosphere. Diatomic oxygen is used by complex life forms such as animals, in cellular respiration. Medical oxygen is widely used in clinical practice to provide a basis for most modern anaesthetic techniques; to restore the tissue oxygen tension towards normal by improving oxygen availability in a wide range of conditions such as shock, severe haemorrhage, coronary occlusion, carbon monoxide poisoning, major trauma; to aid the resuscitation of the critically ill, when the circulation is impaired; to aid in neonatal resuscitation; to treat acute severe headache in adults diagnosed with cluster headache.
CNS Activity
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: GO:0009060 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseNormobaric oxygen is widely recommended for patients with acute myocardial infarction. The randomized phase 3 clinical trial, however, did not demonstrate reduction in 1-year all-cause mortality compared to ambient air group. |
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| Primary | Unknown Approved UseMedical oxygen is widely used in clinical practice to provide a basis for most modern anesthetic techniques; to restore the tissue oxygen tension towards normal by improving oxygen availability in a wide range of conditions such as shock, severe hemorrhage, coronary occlusion, carbon monoxide poisoning, major trauma. |
|||
| Primary | Unknown Approved UseMedical oxygen is widely used in clinical practice to treat acute severe headache in adults diagnosed with a cluster headache. |
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| Primary | Unknown Approved UseMedical oxygen is widely used in clinical practice to restore the tissue oxygen tension towards normal by improving oxygen availability in a wide range of conditions such as shock, severe hemorrhage, coronary occlusion, carbon monoxide poisoning, major trauma. |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Oxygen-regulated expression of the Wilms' tumor suppressor Wt1 involves hypoxia-inducible factor-1 (HIF-1). | 2003-07 |
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| Induction of T-type calcium channel gene expression by chronic hypoxia. | 2003-06-20 |
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| Redox regulation of HIF-1alpha levels and HO-1 expression in renal medullary interstitial cells. | 2003-06 |
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| Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha. | 2003-05-02 |
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| The cellular oxygen tension regulates expression of the endoplasmic oxidoreductase ERO1-Lalpha. | 2003-05 |
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| Retinal oxygen: fundamental and clinical aspects. | 2003-04 |
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| Use of helium-oxygen mixtures in the treatment of acute asthma: a systematic review. | 2003-03 |
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| Heliox vs air-oxygen mixtures for the treatment of patients with acute asthma: a systematic overview. | 2003-03 |
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| Hyperbaric oxygen for treating wounds: a systematic review of the literature. | 2003-03 |
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| Oxygen administration in infants. | 2003-03 |
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| Vascular endothelial growth factor in the cerebrospinal fluid of infants who died of sudden infant death syndrome: evidence for antecedent hypoxia. | 2003-02 |
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| Suppression of tumor necrosis factor-alpha by beta2-adrenoceptor activation: role of mitogen-activated protein kinases in renal mesangial cells. | 2003-01 |
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| Airway chemotransduction: from oxygen sensor to cellular effector. | 2002-12-15 |
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| Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling. | 2002-12-15 |
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| Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells. | 2002-12-06 |
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| Increased migration of murine keratinocytes under hypoxia is mediated by induction of urokinase plasminogen activator. | 2002-12 |
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| Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets. | 2002-12 |
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| Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span. | 2002-11 |
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| Hyperbaric oxygen for cyclophosphamide-induced cystitis. | 2002-11 |
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| Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species. | 2002-11 |
|
| Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). | 2002-10-25 |
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| The role of hypoxia-inducible signaling pathway in nickel carcinogenesis. | 2002-10 |
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| Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar. | 2002-10 |
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| Growth inhibitory factor prevents neurite extension and the death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging. | 2002-08-30 |
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| NADPH oxidase(s): new source(s) of reactive oxygen species in the vascular system? | 2002-08 |
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| Response of VEGF expression to amino acid deprivation and inducers of endoplasmic reticulum stress. | 2002-08 |
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| Reactive species mediated injury of human lung epithelial cells after hypoxia-reoxygenation. | 2002-07-05 |
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| Oxygen therapy for infants with chronic lung disease. | 2002-07 |
|
| Inhibitors of mitochondrial complex I attenuate the accumulation of hypoxia-inducible factor-1 during hypoxia in Hep3B cells. | 2002-05 |
|
| Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis. | 2002-05 |
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| The dietary flavonoid quercetin modulates HIF-1 alpha activity in endothelial cells. | 2002-04-26 |
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| Role of mitochondrial oxidant generation in endothelial cell responses to hypoxia. | 2002-04-01 |
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| Hypoxia increases leptin expression in human PAZ6 adipose cells. | 2002-04 |
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| Serum SP-D is a marker of lung injury in rats. | 2002-04 |
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| Endothelial nitric oxide synthase lies downstream from angiotensin II-induced angiogenesis in ischemic hindlimb. | 2002-03-01 |
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| Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth. | 2002-02-15 |
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| Stabilization of hypoxia-inducible factor-1alpha is involved in the hypoxic stimuli-induced expression of vascular endothelial growth factor in osteoblastic cells. | 2002-01-07 |
|
| Basic toxicological approach has been effective in two poisoned patients with amitraz ingestion: case reports. | 2002-01 |
|
| Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite. | 2001-12-21 |
|
| Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis. | 2001-11-30 |
|
| Differential expression of adrenomedullin and its receptor component, receptor activity modifying protein (RAMP) 2 during hypoxia in cultured human neuroblastoma cells. | 2001-11 |
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| A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses. | 2001-11 |
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| Hypoxia reduces alveolar epithelial sodium and fluid transport in rats: reversal by beta-adrenergic agonist treatment. | 2001-11 |
|
| Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia. | 2001-09 |
|
| Hypoxic preconditioning induces changes in HIF-1 target genes in neonatal rat brain. | 2001-09 |
|
| Prevention of further cyclophosphamide induced hemorrhagic cystitis by hyperbaric oxygen and mesna in guinea pigs. | 2001-09 |
|
| Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase. | 2001-08-28 |
|
| Dependence of excitotoxic neurodegeneration on mitochondrial aconitase inactivation. | 2001-08 |
|
| Recovery from oxidant-mediated lung injury: response of metallothionein, MIP-2, and MCP-1 to nitrogen dioxide, oxygen, and ozone exposures. | 2001-08 |
|
| Sensory nerves promote ozone-induced lung inflammation in mice. | 2001-07-15 |
Patents
Sample Use Guides
Medical oxygen is administered by inhalation through the lungs. The major exception is when a metered supply is fed into the oxygenator of an extracorporeal circulation of a cardiopulmonary by-pass system. For a cluster headache, oxygen should be administered as soon as possible after the onset of the attack, via a non-rebreathing facemask at a flow of 6 to 12 l/min for approximately 15 minutes.
Route of Administration:
Respiratory
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:33:19 GMT 2025
by
admin
on
Mon Mar 31 22:33:19 GMT 2025
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| Record UNII |
0S9K0E25FL
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| Record Status |
Validated (UNII)
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| Record Version |
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C1421
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11062-77-4
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0S9K0E25FL
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C852
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18421
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DTXSID30891408
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0S9K0E25FL
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Superoxide
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