Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H7NO |
| Molecular Weight | 133.1476 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C1CC2=CC=CC=C2N1
InChI
InChIKey=JYGFTBXVXVMTGB-UHFFFAOYSA-N
InChI=1S/C8H7NO/c10-8-5-6-3-1-2-4-7(6)9-8/h1-4H,5H2,(H,9,10)
| Molecular Formula | C8H7NO |
| Molecular Weight | 133.1476 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Design, synthesis and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part I. | 2006-04-15 |
|
| Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2. | 2006-04-15 |
|
| Highly diastereoselective one-pot synthesis of spirocyclic oxindoles through intramolecular Ullmann coupling and Claisen rearrangement. | 2006-03-27 |
|
| Targeting receptor kinases by a novel indolinone derivative in multiple myeloma: abrogation of stroma-derived interleukin-6 secretion and induction of apoptosis in cytogenetically defined subgroups. | 2006-03-01 |
|
| Fate of 3,3'-diindolylmethane in cultured MCF-7 human breast cancer cells. | 2006-03 |
|
| Synthesis and pharmacological profile of an orally-active growth hormone secretagogue, SM-130686. | 2006-03 |
|
| A water soluble extract from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin. | 2006-03 |
|
| Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells. | 2006-03 |
|
| Distribution, metabolism, and excretion of the anti-angiogenic compound SU5416. | 2006-03 |
|
| Synthesis of the putative structure of fistulosin using the ruthenium-catalyzed cycloisomerization of diene. | 2006-02-03 |
|
| A new chemical tool for exploring the physiological function of the PDE2 isozyme. | 2006-01-15 |
|
| Oxindole synthesis through intramolecular nucleophilic addition of vinylpalladiums to aryl isocyanates. | 2005-12-02 |
|
| In silico fragment-based discovery of indolin-2-one analogues as potent DNA gyrase inhibitors. | 2005-12-01 |
|
| Preparation of 3-spirocyclic indolin-2-ones as ligands for the ORL-1 receptor. | 2005-11-15 |
|
| Facile synthesis of active antitubercular, cytotoxic and antibacterial agents: a Michael addition approach. | 2005-11 |
|
| Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: a randomized controlled trial [ISRCTN38432711]. | 2005-10-21 |
|
| Inflammation 2005 - Seventh World Congress. Highlights I. | 2005-10 |
|
| Rapid access to the Welwitindolinone alkaloid skeleton by cyclization of indolecarboxaldehyde substituted cyclohexanones. | 2005-09-15 |
|
| Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis: a review. | 2005-09 |
|
| Indolin-2-ones with high in vivo efficacy in a model for multiple sclerosis. | 2005-08-25 |
|
| Stereoselective synthesis of 3-alkylideneoxindoles via palladium-catalyzed domino reactions. | 2005-08-19 |
|
| SAR studies of 6-aryl-1,3-dihydrobenzimidazol-2-ones as progesterone receptor antagonists. | 2005-08-01 |
|
| Catalytic enantioselective fluorination of oxindoles. | 2005-07-27 |
|
| Identification of degradation products of diclofenac by electrospray ion trap mass spectrometry. | 2005-07-15 |
|
| Suppressive effects of isorhynchophylline on 5-HT2A receptor function in the brain: behavioural and electrophysiological studies. | 2005-07-11 |
|
| Investigating the neuroprotective mechanism of action of a CDK5 inhibitor by phosphoproteome analysis. | 2005-07-01 |
|
| Nitrated and oxidized products of a single tryptophan residue in human Cu,Zn-superoxide dismutase treated with either peroxynitrite-carbon dioxide or myeloperoxidase-hydrogen peroxide-nitrite. | 2005-07 |
|
| Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa. | 2005-07 |
|
| Scavenging of reactive oxygen species by novel indolin-2-one and indoline-2-thione derivatives. | 2005-07 |
|
| TiCl4 catalyzed tandem construction of C-C and C-O bonds: a simple and one-pot atom-economical stereoselective synthesis of spiro-oxindoles. | 2005-05-28 |
|
| Identification of natural dyes used in works of art by pyrolysis-gas chromatography/mass spectrometry combined with in situ trimethylsilylation. | 2005-05 |
|
| Structure-activity relationships of the oxindole growth hormone secretagogues. | 2005-04-01 |
|
| A-432411, a novel indolinone compound that disrupts spindle pole formation and inhibits human cancer cell growth. | 2005-04 |
|
| AG-041R, a novel indoline-2-one derivative, stimulates chondrogenesis in a bipotent chondroprogenitor cell line CL-1. | 2005-04 |
|
| Phosphoproteome and transcriptome analysis of the neuronal response to a CDK5 inhibitor. | 2005-04 |
|
| Antiangiogenic drugs synergize with a membrane macrophage colony-stimulating factor-based tumor vaccine to therapeutically treat rats with an established malignant intracranial glioma. | 2005-03-01 |
|
| Indol-2-one intermediates: mechanistic evidence and synthetic utility. Total syntheses of (+/-)-flustramines A and C. | 2005-02-17 |
|
| HPLC quantification of uncarine D and the anti-plasmodial activity of alkaloids from leaves of Mitragyna inermis (Willd.) O. Kuntze. | 2005-02-04 |
|
| An active ingredient of Cat's Claw water extracts identification and efficacy of quinic acid. | 2005-01-15 |
|
| Genotoxic and cytotoxic studies of beta-sitosterol and pteropodine in mouse. | 2005 |
|
| Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis. | 2005 |
|
| Palladium-catalyzed asymmetric allylation of prochiral nucleophiles: synthesis of 3-allyl-3-aryl oxindoles. | 2004-12-27 |
|
| MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo. | 2004-12-20 |
|
| Identification of indigoid dyes in natural organic pigments used in historical art objects by high-performance liquid chromatography coupled to electrospray ionization mass spectrometry. | 2004-12 |
|
| A Lewis acid-promoted cyclization of ethenetricarboxylate derivative aromatic compounds. Novel syntheses of oxindoles and benzofuranones via Friedel-Crafts intramolecular Michael addition. | 2004-11-07 |
|
| 3-amino thioacridone inhibits DNA synthesis and induce DNA damage in T-cell acute lymphoblastic leukemia (T-ALL) in a p16-dependent manner. | 2004-10 |
|
| Methanol extracts of Hamelia patens containing oxindole alkaloids relax KCl-induced contraction in rat myometrium. | 2004-10 |
|
| One-pot homolytic aromatic substitutions/HWE olefinations under microwave conditions for the formation of a small oxindole library. | 2004-09-30 |
|
| Tissue distribution of molidone in a multidrug overdose. | 2004-09 |
|
| Cellular effects and antitumor activity of RET inhibitor RPI-1 on MEN2A-associated medullary thyroid carcinoma. | 2004-07-07 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:01:34 GMT 2025
by
admin
on
Mon Mar 31 19:01:34 GMT 2025
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| Record UNII |
0S9338U62H
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| Record Status |
FAILED
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| Record Version |
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31697
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321710
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274863
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59-48-3
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241-069-9
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16990-73-1
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OXINDOLE
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200-429-5
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DTXSID80870389
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0S9338U62H
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C022960
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| Related Record | Type | Details | ||
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PARENT -> IMPURITY | |||
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PARENT -> IMPURITY |
