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Details

Stereochemistry ACHIRAL
Molecular Formula C8H7NO
Molecular Weight 133.1473
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OXINDOLE

SMILES

O=C1CC2=CC=CC=C2N1

InChI

InChIKey=JYGFTBXVXVMTGB-UHFFFAOYSA-N
InChI=1S/C8H7NO/c10-8-5-6-3-1-2-4-7(6)9-8/h1-4H,5H2,(H,9,10)

HIDE SMILES / InChI
Molecular Formula C8H7NO
Molecular Weight 133.1473
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Novel oxindole derivatives and their biological activity.
2001
AG-041R, a novel indoline-2-one derivative, induces systemic cartilage hyperplasia in rats.
2001 Apr 27
Synthesis, absolute configuration, and enantiomeric enrichment of a cruciferous oxindole phytoalexin, (S)-(-)-spirobrassinin, and its oxazoline analog.
2001 Jun 1
Relationship between structures of substituted indolic compounds and their degradation by marine anaerobic microorganisms.
2002
Enantioselective total synthesis of quadrigemine C and psycholeine.
2002 Aug 7
Design, synthesis, and SAR of monobenzamidines and aminoisoquinolines as factor Xa inhibitors.
2002 Jun 17
Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content.
2002 May
Enantiospecific, stereospecific total synthesis of the oxindole alkaloid alstonisine.
2002 Nov 28
SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase.
2002 Oct 15
AG-041R stimulates cartilage matrix synthesis without promoting terminal differentiation in rat articular chondrocytes.
2003 Feb
[Effects of 3-substituted aryl oxindole(PH II-7) on cell cycle of tumor cells].
2003 Nov
Identification of indigoid dyes in natural organic pigments used in historical art objects by high-performance liquid chromatography coupled to electrospray ionization mass spectrometry.
2004 Dec
MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo.
2004 Dec 20
A holistic passive integrative sampling approach for assessing the presence and potential impacts of waterborne environmental contaminants.
2004 Feb
Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis.
2005
Stereoselective synthesis of 3-alkylideneoxindoles via palladium-catalyzed domino reactions.
2005 Aug 19
Indolin-2-ones with high in vivo efficacy in a model for multiple sclerosis.
2005 Aug 25
An active ingredient of Cat's Claw water extracts identification and efficacy of quinic acid.
2005 Jan 15
Nitrated and oxidized products of a single tryptophan residue in human Cu,Zn-superoxide dismutase treated with either peroxynitrite-carbon dioxide or myeloperoxidase-hydrogen peroxide-nitrite.
2005 Jul
Suppressive effects of isorhynchophylline on 5-HT2A receptor function in the brain: behavioural and electrophysiological studies.
2005 Jul 11
Catalytic enantioselective fluorination of oxindoles.
2005 Jul 27
Identification of natural dyes used in works of art by pyrolysis-gas chromatography/mass spectrometry combined with in situ trimethylsilylation.
2005 May
Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis: a review.
2005 Sep
Rapid access to the Welwitindolinone alkaloid skeleton by cyclization of indolecarboxaldehyde substituted cyclohexanones.
2005 Sep 15
Synthesis of the putative structure of fistulosin using the ruthenium-catalyzed cycloisomerization of diene.
2006 Feb 3
Fate of 3,3'-diindolylmethane in cultured MCF-7 human breast cancer cells.
2006 Mar
Synthesis and pharmacological profile of an orally-active growth hormone secretagogue, SM-130686.
2006 Mar
Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells.
2006 Mar
Distribution, metabolism, and excretion of the anti-angiogenic compound SU5416.
2006 Mar
Targeting receptor kinases by a novel indolinone derivative in multiple myeloma: abrogation of stroma-derived interleukin-6 secretion and induction of apoptosis in cytogenetically defined subgroups.
2006 Mar 1
Patents

Patents

03975531
3
04002749
1
04045576
2
04053483
1
JP2000026412A
1
JP2000355591A
1
JP2001302631A
4
JP2002517457A
1
JP2002517459A
1
JP2002517460A
1
JP2002540096A
1
JP2003527437A
1
JP2004182726A
1
JP2005289896A
1
JP2007084540A
1
JP2007513105A
2
JP2007523951A
2
JP2008050354A
1
JP2008101014A
1
JP2008502692A
5
JP2010121147A
1
JP2011037848A
1
JP2011514412A
1
JP2011526615A
1
JP2011527334A
1
JP3507497B2
1
JP4796047B2
1
JP4834663B2
3
JP5318781B2
1
JP5336686B2
1
JPH02247174A
1
JPH02292258A
1
JPH0311061A
1
JPH03178963A
1
JPH04342566A
1
JPH07118261A
1
JPH07196611A
1
JPH07224034A
1
JPH07238069A
1
JPH07247269A
1
JPH0748349A
1
JPH08333336A
1
JPH0940557A
1
JPH1077230A
1
JPH11180952A
1
JPS06122014A
1
JPS54151963A
1
JPS5668668A
1
JPS57179158A
1
JPS61109767A
1
JPS6122014A
1
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:03:21 GMT 2023
Edited
by admin
on Fri Dec 15 18:03:21 GMT 2023
Record UNII
0S9338U62H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
OXINDOLE
Systematic Name English
2-OXINDOLE
Common Name English
INDOL-2-OL
Systematic Name English
DICLOFENAC POTASSIUM IMPURITY I [EP IMPURITY]
Common Name English
2-HYDROXYINDOLE
Systematic Name English
INDOLINE-2-ONE
Systematic Name English
DICLOFENAC SODIUM IMPURITY E [EP IMPURITY]
Common Name English
1,3-DIHYDROINDOL-2-ONE
Systematic Name English
2-INDOLINONE
Systematic Name English
1H-INDOL-2-OL
Systematic Name English
2H-INDOL-2-ONE, 1,3-DIHYDRO-
Systematic Name English
NSC-274863
Code English
1,3-DIHYDRO-2H-INDOL-2-ONE
Systematic Name English
DICLOFENAC IMPURITY E
Common Name English
DICLOFENAC POTASSIUM IMPURITY E [EP IMPURITY]
Common Name English
INDOL-2(3H)-ONE
Systematic Name English
Code System Code Type Description
CHEBI
31697
Created by admin on Fri Dec 15 18:03:21 GMT 2023 , Edited by admin on Fri Dec 15 18:03:21 GMT 2023
PRIMARY
PUBCHEM
321710
Created by admin on Fri Dec 15 18:03:21 GMT 2023 , Edited by admin on Fri Dec 15 18:03:21 GMT 2023
PRIMARY
NSC
274863
Created by admin on Fri Dec 15 18:03:21 GMT 2023 , Edited by admin on Fri Dec 15 18:03:21 GMT 2023
PRIMARY
CAS
59-48-3
Created by admin on Fri Dec 15 18:03:21 GMT 2023 , Edited by admin on Fri Dec 15 18:03:21 GMT 2023
PRIMARY
ECHA (EC/EINECS)
241-069-9
Created by admin on Fri Dec 15 18:03:21 GMT 2023 , Edited by admin on Fri Dec 15 18:03:21 GMT 2023
ALTERNATIVE
CAS
16990-73-1
Created by admin on Fri Dec 15 18:03:21 GMT 2023 , Edited by admin on Fri Dec 15 18:03:21 GMT 2023
ALTERNATIVE
WIKIPEDIA
OXINDOLE
Created by admin on Fri Dec 15 18:03:21 GMT 2023 , Edited by admin on Fri Dec 15 18:03:21 GMT 2023
PRIMARY
ECHA (EC/EINECS)
200-429-5
Created by admin on Fri Dec 15 18:03:21 GMT 2023 , Edited by admin on Fri Dec 15 18:03:21 GMT 2023
PRIMARY
EPA CompTox
DTXSID80870389
Created by admin on Fri Dec 15 18:03:21 GMT 2023 , Edited by admin on Fri Dec 15 18:03:21 GMT 2023
PRIMARY
FDA UNII
0S9338U62H
Created by admin on Fri Dec 15 18:03:21 GMT 2023 , Edited by admin on Fri Dec 15 18:03:21 GMT 2023
PRIMARY
MESH
C022960
Created by admin on Fri Dec 15 18:03:21 GMT 2023 , Edited by admin on Fri Dec 15 18:03:21 GMT 2023
PRIMARY
Related Record Type Details
Structure of DICLOFENAC POTASSIUM
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of DICLOFENAC SODIUM
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
NIH
NCATS
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