CHLORMIDAZOLE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H13ClN2.ClH
Molecular Weight	293.191
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of CHLORMIDAZOLE HYDROCHLORIDE

Structure Search

SMILES

Cl.CC1=NC2=CC=CC=C2N1CC3=CC=C(Cl)C=C3

InChI

InChIKey=MHMTXDMLQZHXRZ-UHFFFAOYSA-N

InChI=1S/C15H13ClN2.ClH/c1-11-17-14-4-2-3-5-15(14)18(11)10-12-6-8-13(16)9-7-12;/h2-9H,10H2,1H3;1H

HIDE SMILES / InChI

Molecular Formula	C15H13ClN2
Molecular Weight	256.73
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://leki-opinie.pl/polfungicid-plyn | https://www.ncbi.nlm.nih.gov/pubmed/945306 | https://www.ncbi.nlm.nih.gov/pubmed/2395759

Chlormidazole was the first azole introduced the treatment of topical mycosis. It demonstrated inhibitory activity against many fungi and some gram-positive cocci. It is used for the treatment of fungal and bacterial infections of nails and skin, including interdigital and periungual mycoses. Possible side effects are: local skin irritation, burning, itching.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Dermatomycosis 20 Sources: https://www.ncbi.nlm.nih.gov/pubmed/725113 https://www.ncbi.nlm.nih.gov/pubmed/129703 https://www.ncbi.nlm.nih.gov/pubmed/945306	Curative		Approved 8429	Myco-polycid Approved Use Indicated for the treatment of fungal and fungal-bacterial (mixed) skin and nail infections (including interdigital and periungual mycoses).

PubMed

Title	Date	PubMed
[Sensitivity of aerobic bacteria and Candida species to chlormidazole hydrochloride in vitro].	1990 Jan 22-29	2395759
Azole antimycotics--a highway to new drugs or a dead end?	2012	22257053

Patents

Sample Use Guides

In Vivo Use Guide

2-3 times per day; Treatment should be continued for at least 4 weeks after complete elimination of discomfort.

Route of Administration: Topical

In Vitro Use Guide

Over 100 bacterial stains, including Candida sp., gram-positive cocci and some gram-negative bacilli, were tested. The majority of microorganisms was isolated from man. Only one bacterial strain (5 ug/mL) and 76% of Candida strains were sensitive to chlormidazole HCl (10 ug/mL).

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:48:20 GMT 2023` Edited by `admin` on `Fri Dec 15 18:48:20 GMT 2023`
Record UNII	0RH29TB951
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CHLORMIDAZOLE HYDROCHLORIDE

Common Name

English

UNFUNGICID

Common Name

English

1-(P-CHLOROBENZYL)-2-METHYL-1H-BENZIMIDAZOLE HYDROCHLORIDE

Common Name

English

CHLORMIDAZOLE HYDROCHLORIDE [MI]

Common Name

English

Chlormidazole hydrochloride [WHO-DD]

Common Name

English

CHLORMIDAZOLE HYDROCHLORIDE [MART.]

Common Name

English

Code System Code Type Description

SMS_ID

100000080073