CYCLOBUTANECARBOXYLIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H8O2
Molecular Weight	100.1158
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)C1CCC1

InChI

InChIKey=TXWOGHSRPAYOML-UHFFFAOYSA-N

InChI=1S/C5H8O2/c6-5(7)4-2-1-3-4/h4H,1-3H2,(H,6,7)

HIDE SMILES / InChI

Molecular Formula	C5H8O2
Molecular Weight	100.1158
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: DOI: 10.1021/jo01158a011 | https://www.ncbi.nlm.nih.gov/pubmed/5969053 | https://www.ncbi.nlm.nih.gov/pubmed/1261667

Cyclobutanecarboxylic acid has been the principal starting material for preparation of monosubstituted cyclobutane derivatives. The urea derivatives of cyclobutanecarboxylic acid have central nervous system depressant qualities while the hydrazines and heterocyclic amides are either inactive or have central nervous system excitatory properties.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Conformation of 2-aminomethylpyrrolidine and 2-aminomethylpiperidine in ternary platinum(II) complexes: regulation of conformation of the diamine by the coexisting ligand.	2003 Oct	14519921
Tetra-μ(2)-oxido-di-μ(4)-peroxido-tetra-kis[diphenyl-anti-mony(V)] chloro-form disolvate.	2009 Feb 6	21582046
Total synthesis of punctaporonin C by a regio- and stereoselective [2+2]-photocycloaddition.	2010 May 25	20411543
Synthesis of chitin cycloalkyl ester derivatives and their physical properties.	2010 Sep 23	20691431

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Cyclobutanecarboxylic acid has low inhibition efficacy on glucose formation from pyruvate by rat kidney slices. At concentration of Cyclobutanecarboxylic acid 0.01 mM glucose formation was inhibited by 9.5%, at 1.0 mM – by 4.4%.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:42:57 GMT 2023` Edited by `admin` on `Fri Dec 15 19:42:57 GMT 2023`
Record UNII	0RDJ7C51O0
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CYCLOBUTANECARBOXYLIC ACID

Systematic Name

English

CYCLOBUTANE-1-CARBOXYLIC ACID

Systematic Name

English

NSC-4535

Code

English

CYCLOBUTYLCARBOXYLIC ACID

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID3057725