Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H26FN3O5.ClH |
| Molecular Weight | 467.918 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.C[C@H](N)C(=O)OC1CCN(CC1)C2=C(F)C=C3C(=O)C(=CN4[C@@H](C)CCC2=C34)C(O)=O
InChI
InChIKey=XWWJPQYPMLTWRH-FXMYHANSSA-N
InChI=1S/C22H26FN3O5.ClH/c1-11-3-4-14-18-15(20(27)16(21(28)29)10-26(11)18)9-17(23)19(14)25-7-5-13(6-8-25)31-22(30)12(2)24;/h9-13H,3-8,24H2,1-2H3,(H,28,29);1H/t11-,12-;/m0./s1
| Molecular Formula | C22H26FN3O5 |
| Molecular Weight | 431.4573 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Levonadifloxacin is the S-(-) isomer of the benzoquinolizine fluoroquinolone nadifloxacin and is two- to four-fold more active than the racemic mixture. Levonadifloxacin is a potent antibacterial agent against Gram-positive bacteria especially against methicillin resistance Staphylococcus aureus. It also possesses potent bactericidal activity against other resistant variants like quinolone-resistant Staphylococcus aureus, vancomycin and glycopeptide intermediate Staphylococcus aureus and vancomycin resistant Staphylococcus aureus. Intravenous dosage form developed to treat complicated skin and skin structure infections and has recently completed Phase III studies in India and Phase I studies in USA.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Antianaerobic activity of a novel fluoroquinolone, WCK 771, compared to those of nine other agents. | 2004 Aug |
|
| Activity of the new quinolones WCK 771, WCK 1152 and WCK 1153 against clinical isolates of Streptococcus pneumoniae and Streptococcus pyogenes. | 2005 Dec |
|
| Validated chiral high-performance liquid chromatography method for a novel anti-methicillin-resistant Staphylococcus aureus fluoroquinolone WCK 771. | 2006 Mar 3 |
|
| Electrocardiographic Effects of a Supratherapeutic Dose of WCK 2349, a Benzoquinolizine Fluoroquinolone. | 2019 Jan |
|
| Identification of metabolites of novel Anti-MRSA fluoroquinolone WCK 771 in mouse, rat, rabbit, dog, monkey and human urine using liquid chromatography tandem mass spectrometry. | 2019 Jul |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:34:48 GMT 2023
by
admin
on
Fri Dec 15 17:34:48 GMT 2023
|
| Record UNII |
0QZX09B73G
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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24983857
Created by
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0QZX09B73G
Created by
admin on Fri Dec 15 17:34:48 GMT 2023 , Edited by admin on Fri Dec 15 17:34:48 GMT 2023
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396132-82-4
Created by
admin on Fri Dec 15 17:34:48 GMT 2023 , Edited by admin on Fri Dec 15 17:34:48 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> SALT/SOLVATE |
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