HALOMETASONE MONOHYDRATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H27ClF2O5.H2O
Molecular Weight	462.912
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])C[C@H](F)C4=CC(=O)C(Cl)=C[C@]34C

InChI

InChIKey=LIVSBYNMLPEZHQ-DNGJBDHLSA-N

InChI=1S/C22H27ClF2O5.H2O/c1-10-4-11-12-5-15(24)13-6-16(27)14(23)7-19(13,2)21(12,25)17(28)8-20(11,3)22(10,30)18(29)9-26;/h6-7,10-12,15,17,26,28,30H,4-5,8-9H2,1-3H3;1H2/t10-,11+,12+,15+,17+,19+,20+,21+,22+;/m1./s1

HIDE SMILES / InChI

Molecular Formula	C22H27ClF2O5
Molecular Weight	444.897
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	9 / 9
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/29250537 | https://www.ncbi.nlm.nih.gov/pubmed/24307924 | https://www.ncbi.nlm.nih.gov/pubmed/6339290

Halometasone, a high-potency topical glucocorticoid that inhibits inflammation, epidermal hyperplasia, and allergic reactions, constrict blood vessels and relieve pruritus. Halometasone as the cream is used for the treatment of patients with chronic psoriasis vulgaris, eczematous dermatoses, and occupational contact dermatitis. Besides, this drug can reduce acute adverse effects induced by pulsed dye laser for the treatment of port wine stain (PWS) birthmarks. Halometasone acts via the binding to steroid receptors to modulate the protein synthesis and to regulate the function of inflammatory cells and lysosomes and ultimately to reduce inflammatory responses.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glucocorticoid receptor 172 Target ID: P04150 Gene ID: 2908.0 Gene Symbol: NR3C1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/29250537	Modulator 828

Patents

Sample Use Guides

In Vivo Use Guide

1.41% of halometasone cream used for consecutive 7 days on a lesion area of 400 cm2 can be absorbed via the skin

Route of Administration: Topical

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:33:22 GMT 2023` Edited by `admin` on `Sat Dec 16 01:33:22 GMT 2023`
Record UNII	0PJ4SNG9CS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HALOMETASONE MONOHYDRATE

Common Name

English

SICORTEN

Brand Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 2-CHLORO-6,9-DIFLUORO-11,17,21-TRIHYDROXY-16-METHYL-, HYDRATE (1:1), (6.ALPHA.,11.BETA.,16.ALPHA.)-

Common Name

English

Halometasone monohydrate [WHO-DD]

Common Name

English

Code System Code Type Description

FDA UNII

0PJ4SNG9CS