| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H27ClF2O5.H2O |
| Molecular Weight | 462.912 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 9 / 9 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C(Cl)=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
InChI
InChIKey=LIVSBYNMLPEZHQ-DNGJBDHLSA-N
InChI=1S/C22H27ClF2O5.H2O/c1-10-4-11-12-5-15(24)13-6-16(27)14(23)7-19(13,2)21(12,25)17(28)8-20(11,3)22(10,30)18(29)9-26;/h6-7,10-12,15,17,26,28,30H,4-5,8-9H2,1-3H3;1H2/t10-,11+,12+,15+,17+,19+,20+,21+,22+;/m1./s1
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C22H27ClF2O5 |
| Molecular Weight | 444.897 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 9 / 9 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Halometasone, a high-potency topical glucocorticoid that inhibits inflammation, epidermal hyperplasia, and allergic reactions, constrict blood vessels and relieve pruritus. Halometasone as the cream is used for the treatment of patients with chronic psoriasis vulgaris, eczematous dermatoses, and occupational contact dermatitis. Besides, this drug can reduce acute adverse effects induced by pulsed dye laser for the treatment of port wine stain (PWS) birthmarks. Halometasone acts via the binding to steroid receptors to modulate the protein synthesis and to regulate the function of inflammatory cells and lysosomes and ultimately to reduce inflammatory responses.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
