Details
| Stereochemistry | MIXED |
| Molecular Formula | C20H29NO2.ClH |
| Molecular Weight | 351.911 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.OC(COC1CN2CCC1CC2)(C3CCCC3)C4=CC=CC=C4
InChI
InChIKey=DDTVVMRZNVIVQM-UHFFFAOYSA-N
InChI=1S/C20H29NO2.ClH/c22-20(18-8-4-5-9-18,17-6-2-1-3-7-17)15-23-19-14-21-12-10-16(19)11-13-21;/h1-3,6-7,16,18-19,22H,4-5,8-15H2;1H
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C20H29NO2 |
| Molecular Weight | 315.4498 |
| Charge | 0 |
| Count |
|
| Stereochemistry | MIXED |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Penequinine (penehyclidine) is a selective M1/M2 receptor antagonist. Due to anticholinergic effects, penequinine is used in Chine for the treatment of organophosphorus and soman poisoning. In addition, penequinine is a negative regulator of TLR4 and NF-kB signaling and is investigated as a potential treatment in clinical trials for the treatment of acute lung injury and acute cerebral ischemia-reperfusion injury.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Fertility and early embryonic development toxicity of penequine hydrochloride in mice. | 2007-06 |
|
| Embryo-fetal development toxicity of prenatal exposure to penequine hydrochloride intramuscularly in rats. | 2007-04 |
|
| The pre- and post-natal toxicity of penequine hydrochloride in mice. | 2006-11 |
|
| Synthesis of the optical isomers of a new anticholinergic drug, penehyclidine hydrochloride (8018). | 2005-04-15 |
|
| Effects of pretreatment with 8018 on the toxicokinetics of soman in rabbits and distribution in mice. | 2003-07-11 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Tue Apr 01 21:53:43 GMT 2025
by
admin
on
Tue Apr 01 21:53:43 GMT 2025
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| Record UNII |
0P1E1UF04I
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| Record Status |
Validated (UNII)
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151937-76-7
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300000028373
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DTXSID90934385
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0P1E1UF04I
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ACTIVE MOIETY |
