Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C17H14F2O3 |
| Molecular Weight | 304.2881 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(CC(=O)C1=CC=C(C=C1)C2=CC=C(F)C=C2F)C(O)=O
InChI
InChIKey=FIKVYIRIUOFLLR-UHFFFAOYSA-N
InChI=1S/C17H14F2O3/c1-10(17(21)22)8-16(20)12-4-2-11(3-5-12)14-7-6-13(18)9-15(14)19/h2-7,9-10H,8H2,1H3,(H,21,22)
| Molecular Formula | C17H14F2O3 |
| Molecular Weight | 304.2881 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Liquid chromatographic-electrospray mass spectrometric determination (LC-ESI-MS) of phase II metabolites of flobufen in rat liver microsomes-Chiral discrimination. | 2008-04-15 |
|
| Vancomycin as chiral selector for enantioselective separation of selected profen nonsteroidal anti-inflammatory drugs in capillary liquid chromatography. | 2006-08 |
|
| Synthesis and enhancing effect of transkarbam 12 on the transdermal delivery of theophylline, clotrimazole, flobufen, and griseofulvin. | 2006-05 |
|
| Comparison of vancomycin-based stationary phases with different chiral selector coverage for enantioselective separation of selected drugs in high-performance liquid chromatography. | 2005-09-23 |
|
| Pharmacological profile of 4-(2',4'-difluorobiphenyl-4-yl)-2-methylbutyric acid (deoxoflobufen). | 2005 |
|
| Stereospecificity of flobufen metabolism in guinea pigs in vitro and in vivo: phase I of biotransformation. | 2004-01 |
|
| Stereoselective pharmacokinetics and metabolism of flobufen in guinea pigs. | 2003-10 |
|
| The stereospecificity of flobufen metabolism in isolated guinea pig hepatocytes. | 2003-06-05 |
|
| Chiral aspects of metabolism of antiinflammatory drug flobufen in human hepatocytes. | 2003-05-15 |
|
| Reduction of flobufen in pig hepatocytes: effect of pig breed (domestic, wild) and castration. | 2003-03 |
|
| Enantioseparation of flobufen with cyclodextrins studied by capillary electrophoresis and NMR. | 2001-06 |
|
| Biotransformation of flobufen enantiomers in ruminant hepatocytes and subcellular fractions. | 2001 |
|
| Stereospecificity and stereoselectivity of flobufen metabolic profile in male rats in vitro and in vivo: phase I of biotransformation. | 2001 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:58:16 GMT 2025
by
admin
on
Mon Mar 31 21:58:16 GMT 2025
|
| Record UNII |
0LNC8EZT75
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
112344-52-2
Created by
admin on Mon Mar 31 21:58:16 GMT 2025 , Edited by admin on Mon Mar 31 21:58:16 GMT 2025
|
PRIMARY | |||
|
0LNC8EZT75
Created by
admin on Mon Mar 31 21:58:16 GMT 2025 , Edited by admin on Mon Mar 31 21:58:16 GMT 2025
|
PRIMARY | |||
|
159476
Created by
admin on Mon Mar 31 21:58:16 GMT 2025 , Edited by admin on Mon Mar 31 21:58:16 GMT 2025
|
PRIMARY | |||
|
DTXSID70874896
Created by
admin on Mon Mar 31 21:58:16 GMT 2025 , Edited by admin on Mon Mar 31 21:58:16 GMT 2025
|
PRIMARY | |||
|
104941-35-7
Created by
admin on Mon Mar 31 21:58:16 GMT 2025 , Edited by admin on Mon Mar 31 21:58:16 GMT 2025
|
SUPERSEDED |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
