Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C10H6N8.C7H17NO5 |
Molecular Weight | 433.4218 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.N1N=NN=C1C2=CC3=CC=CC=C3N4N=NN=C24
InChI
InChIKey=HSJVWAIYDFGPSF-WZTVWXICSA-N
InChI=1S/C10H6N8.C7H17NO5/c1-2-4-8-6(3-1)5-7(9-11-14-15-12-9)10-13-16-17-18(8)10;1-8-2-4(10)6(12)7(13)5(11)3-9/h1-5H,(H,11,12,14,15);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1
Molecular Formula | C10H6N8 |
Molecular Weight | 238.2082 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C7H17NO5 |
Molecular Weight | 195.2136 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/2801334
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2801334
Tetrazolast (also known as MDL 26,024GO) is a tetrazoloquinoline derivative patented by Merrell Dow Pharmaceuticals, Inc. as an antiallergic and antiasthmatic agent. Tetrazolast was shown to be an orally absorbed mediator release inhibitor in the rat passive cutaneous anaphylaxis and passive peritoneal anaphylaxis tests. In addition, the compound was shown to both elicit and inhibit elicitation of the Bezold-Jarisch reflex in the dog. Tetrazolast also significantly reduced Ascaris-induced changes in pulmonary mechanics in cynomolgus monkeys. The compound inhibited both early and late phase antigen induced-changes in Ascaris-sensitive sheep, as well as the increased airway hyperreactivity which normally follows antigen challenge.
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 03:58:55 GMT 2023
by
admin
on
Sat Dec 16 03:58:55 GMT 2023
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Record UNII |
0IUX02EV3N
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Record Status |
Validated (UNII)
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Record Version |
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0IUX02EV3N
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95190-13-9
Created by
admin on Sat Dec 16 03:58:55 GMT 2023 , Edited by admin on Sat Dec 16 03:58:55 GMT 2023
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PARENT -> SALT/SOLVATE | |||
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PARENT -> SALT/SOLVATE | |||
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SOLVATE->ANHYDROUS |
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ACTIVE MOIETY |