U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C15H16Cl2N2O8.C6H14N4O2
Molecular Weight 597.403
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHLORAMPHENICOL ARGININE SUCCINATE

SMILES

N[C@@H](CCCNC(N)=N)C(O)=O.O[C@@H]([C@@H](COC(=O)CCC(O)=O)NC(=O)C(Cl)Cl)C1=CC=C(C=C1)[N+]([O-])=O

InChI

InChIKey=VVVYDMROIIOUOA-PZMRBAAZSA-N
InChI=1S/C15H16Cl2N2O8.C6H14N4O2/c16-14(17)15(24)18-10(7-27-12(22)6-5-11(20)21)13(23)8-1-3-9(4-2-8)19(25)26;7-4(5(11)12)2-1-3-10-6(8)9/h1-4,10,13-14,23H,5-7H2,(H,18,24)(H,20,21);4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t10-,13-;4-/m10/s1

HIDE SMILES / InChI
Molecular Formula C15H16Cl2N2O8
Molecular Weight 423.202
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula C6H14N4O2
Molecular Weight 174.201
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Chloramphenicol is a broad-spectrum antibiotic that was first isolated from Streptomyces venezuelae in 1947. The drug was subsequently chemically synthesized. It has both a bacteriostatic and bactericidal effect; in the usual therapeutic concentrations it is bacteriostatic. Chloramphenicol is used for the treatment of serious gram-negative, gram-positive, and anaerobic infections. It is especially useful in the treatment of meningitis, typhoid fever, and cystic fibrosis. It should be reserved for infections for which other drugs are ineffective or contraindicated. Chloramphenicol, a small inhibitor of bacterial protein synthesis, is active against a variety of bacteria and readily enters the CSF. It has been used extensively in the last decades for the treatment of bacterial meningitis. In industrialized countries, chloramphenicol is restricted mostly to topical uses because of the risk of induction of aplastic anemia. However, it remains a valuable reserve antibiotic for patients with allergy to β-lactam antibiotics or with CNS infections caused by multiresistant pathogens.

CNS Activity

Originator

Approval Year

1950
102
Targets

Targets

Primary TargetPharmacologyConditionPotency
Substrate
661
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8429
CHLOROPTIC

Approved Use

Indications and Usage In accord with the concepts in the Warning Box and this section, chloramphenicolmust be used only in those serious infections for which less potentially dangerous drugs are ineffective or contraindicated. However, chloramphenicol may be chosen to initiate antibiotic therapy on the clinical impression that one of the conditions below is believed to be present; in vitro sensitivity tests should be performed concurrently so that the drug may be discontinued as soon as possible if less potentially dangerous agents are indicated by such tests. The decision to continue use of chloramphenicol rather than another antibiotic when both are suggested by in vitro studies to be effective against a specific pathogen should be based upon severity of the infection, susceptibility of the pathogen to the various antimicrobial drugs, efficacy of the various drugs in the infection, and the important additional concepts contained in the Warning Box above. 1. Acute infections caused by Salmonella typhi* It is not recommended for the routine treatment of the typhoid carrier state. 2. Serious infections caused by susceptible strains in accordance with the concepts expressed above: a) Salmonella species b) H. influenzae, specially meningeal infections c) Rickettsia d) Lymphogranuloma-psittacosis group e) Various gram-negative bacteria causing bacteremia, meningitis, or other serious gram-negative infections f) Other susceptible organisms which have been demonstrated to be resistant to all other appropriate antimicrobial agents. 3. Cystic fibrosis regimens *In treatment of typhoid fever some authorities recommend that chloramphenicol be administered at therapeutic levels for 8 to 10 days after the patient has become afebrile to lessen the possibility of relapse.

Launch Date

1968
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
16.9 μg/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/2713219/
500 mg 4 times / day multiple, oral
dose: 500 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
CHLORAMPHENICOL blood
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
59.1 μg × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/2713219/
500 mg 4 times / day multiple, oral
dose: 500 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
CHLORAMPHENICOL blood
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
3.5 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/2713219/
500 mg 4 times / day multiple, oral
dose: 500 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
CHLORAMPHENICOL blood
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
5.1 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/7463235/
25 mg/kg 4 times / day multiple, intravenous
dose: 25 mg/kg
route of administration: Intravenous
experiment type: MULTIPLE
co-administered:
CHLORAMPHENICOL serum
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: UNKNOWN
food status: UNKNOWN
2.2 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/7463235/
25 mg/kg 4 times / day multiple, intravenous
dose: 25 mg/kg
route of administration: Intravenous
experiment type: MULTIPLE
co-administered:
CHLORAMPHENICOL SUCCINATE serum
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
0.5 % 4 times / day multiple, ophthalmic
Recommended
Dose: 0.5 %, 4 times / day
Route: ophthalmic
Route: multiple
Dose: 0.5 %, 4 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/15993231/
unhealthy, 0.5 - 12 years
n = 163
Health Status: unhealthy
Condition: acute infective conjunctivitis
Age Group: 0.5 - 12 years
Sex: unknown
Population Size: 163
Sources:
https://pubmed.ncbi.nlm.nih.gov/15993231/
Other AEs: Swollen eyelid...
Other AEs:
Swollen eyelid (1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/15993231/
0.25 g 1 times / 3 months multiple, intramuscular
Recommended
Dose: 0.25 g, 1 times / 3 months
Route: intramuscular
Route: multiple
Dose: 0.25 g, 1 times / 3 months
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
unhealthy, 11 years
n = 1
Health Status: unhealthy
Condition: infection
Age Group: 11 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
Disc. AE: Aplastic anemia...
AEs leading to
discontinuation/dose reduction:
Aplastic anemia (grade 4, 1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
70 mg/kg 1 times / day steady, intravenous
Recommended
Dose: 70 mg/kg, 1 times / day
Route: intravenous
Route: steady
Dose: 70 mg/kg, 1 times / day
Co-administed with::
(meropenem)
120 mg/kg/day
Sources:
https://pubmed.ncbi.nlm.nih.gov/28186714/
unhealthy, 15 years
n = 1
Health Status: unhealthy
Condition: Cystic Fibrosis and infection
Age Group: 15 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/28186714/
Disc. AE: Hyperlactatemia...
AEs leading to
discontinuation/dose reduction:
Hyperlactatemia (1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/28186714/
3 g 1 times / day multiple, intravenous
Recommended
Dose: 3 g, 1 times / day
Route: intravenous
Route: multiple
Dose: 3 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
unhealthy, 23 years
n = 1
Health Status: unhealthy
Condition: infection
Age Group: 23 years
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
Disc. AE: Aplastic anemia...
AEs leading to
discontinuation/dose reduction:
Aplastic anemia (grade 5, 1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
2.5 g 1 times / day multiple, intravenous
Recommended
Dose: 2.5 g, 1 times / day
Route: intravenous
Route: multiple
Dose: 2.5 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
unhealthy, 27 years
n = 1
Health Status: unhealthy
Condition: infection
Age Group: 27 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
Disc. AE: Aplastic anemia...
AEs leading to
discontinuation/dose reduction:
Aplastic anemia (grade 4, 1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
1 g 1 times / day multiple, parenteral
Recommended
Dose: 1 g, 1 times / day
Route: parenteral
Route: multiple
Dose: 1 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
unhealthy, 39 years
n = 1
Health Status: unhealthy
Condition: infection
Age Group: 39 years
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
Disc. AE: Aplastic anemia...
AEs leading to
discontinuation/dose reduction:
Aplastic anemia (grade 4, 1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
750 mg 4 times / day steady, intravenous
Recommended
Dose: 750 mg, 4 times / day
Route: intravenous
Route: steady
Dose: 750 mg, 4 times / day
Co-administed with::
tobramycin
nafcillin
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
unhealthy, 54 years
n = 1
Health Status: unhealthy
Condition: purulent drainage from the surgical wound
Age Group: 54 years
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
Disc. AE: Aplastic anemia...
AEs leading to
discontinuation/dose reduction:
Aplastic anemia (grade 5, 1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
4 g 1 times / day multiple, intravenous
Recommended
Dose: 4 g, 1 times / day
Route: intravenous
Route: multiple
Dose: 4 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
unhealthy, 61 years
n = 1
Health Status: unhealthy
Condition: infection
Age Group: 61 years
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
Disc. AE: Aplastic anemia...
AEs leading to
discontinuation/dose reduction:
Aplastic anemia (grade 5, 1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
1 g 1 times / day multiple, intramuscular
Recommended
Dose: 1 g, 1 times / day
Route: intramuscular
Route: multiple
Dose: 1 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
unhealthy, 68 years
n = 1
Health Status: unhealthy
Condition: infection
Age Group: 68 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
Disc. AE: Aplastic anemia...
AEs leading to
discontinuation/dose reduction:
Aplastic anemia (grade 4, 1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
2 g 1 times / day multiple, parenteral
Recommended
Dose: 2 g, 1 times / day
Route: parenteral
Route: multiple
Dose: 2 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
unhealthy, 71 years
n = 1
Health Status: unhealthy
Condition: infection
Age Group: 71 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
Disc. AE: Aplastic anemia...
AEs leading to
discontinuation/dose reduction:
Aplastic anemia (grade 5, 1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
3 % 1 times / day multiple, topical
Recommended
Dose: 3 %, 1 times / day
Route: topical
Route: multiple
Dose: 3 %, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/33378750/
unhealthy, adult
n = 23
Health Status: unhealthy
Condition: cancer patients with (EGFRI)-induced papulopustular rash
Age Group: adult
Sex: unknown
Population Size: 23
Sources:
https://pubmed.ncbi.nlm.nih.gov/33378750/
Sources:
https://pubmed.ncbi.nlm.nih.gov/33378750/
AEs

AEs

AESignificanceDosePopulation
Swollen eyelid 1 patient
0.5 % 4 times / day multiple, ophthalmic
Recommended
Dose: 0.5 %, 4 times / day
Route: ophthalmic
Route: multiple
Dose: 0.5 %, 4 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/15993231/
unhealthy, 0.5 - 12 years
n = 163
Health Status: unhealthy
Condition: acute infective conjunctivitis
Age Group: 0.5 - 12 years
Sex: unknown
Population Size: 163
Sources:
https://pubmed.ncbi.nlm.nih.gov/15993231/
Aplastic anemia grade 4, 1 patient
Disc. AE
0.25 g 1 times / 3 months multiple, intramuscular
Recommended
Dose: 0.25 g, 1 times / 3 months
Route: intramuscular
Route: multiple
Dose: 0.25 g, 1 times / 3 months
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
unhealthy, 11 years
n = 1
Health Status: unhealthy
Condition: infection
Age Group: 11 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
Hyperlactatemia 1 patient
Disc. AE
70 mg/kg 1 times / day steady, intravenous
Recommended
Dose: 70 mg/kg, 1 times / day
Route: intravenous
Route: steady
Dose: 70 mg/kg, 1 times / day
Co-administed with::
(meropenem)
120 mg/kg/day
Sources:
https://pubmed.ncbi.nlm.nih.gov/28186714/
unhealthy, 15 years
n = 1
Health Status: unhealthy
Condition: Cystic Fibrosis and infection
Age Group: 15 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/28186714/
Aplastic anemia grade 5, 1 patient
Disc. AE
3 g 1 times / day multiple, intravenous
Recommended
Dose: 3 g, 1 times / day
Route: intravenous
Route: multiple
Dose: 3 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
unhealthy, 23 years
n = 1
Health Status: unhealthy
Condition: infection
Age Group: 23 years
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
Aplastic anemia grade 4, 1 patient
Disc. AE
2.5 g 1 times / day multiple, intravenous
Recommended
Dose: 2.5 g, 1 times / day
Route: intravenous
Route: multiple
Dose: 2.5 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
unhealthy, 27 years
n = 1
Health Status: unhealthy
Condition: infection
Age Group: 27 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
Aplastic anemia grade 4, 1 patient
Disc. AE
1 g 1 times / day multiple, parenteral
Recommended
Dose: 1 g, 1 times / day
Route: parenteral
Route: multiple
Dose: 1 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
unhealthy, 39 years
n = 1
Health Status: unhealthy
Condition: infection
Age Group: 39 years
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
Aplastic anemia grade 5, 1 patient
Disc. AE
750 mg 4 times / day steady, intravenous
Recommended
Dose: 750 mg, 4 times / day
Route: intravenous
Route: steady
Dose: 750 mg, 4 times / day
Co-administed with::
tobramycin
nafcillin
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
unhealthy, 54 years
n = 1
Health Status: unhealthy
Condition: purulent drainage from the surgical wound
Age Group: 54 years
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
Aplastic anemia grade 5, 1 patient
Disc. AE
4 g 1 times / day multiple, intravenous
Recommended
Dose: 4 g, 1 times / day
Route: intravenous
Route: multiple
Dose: 4 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
unhealthy, 61 years
n = 1
Health Status: unhealthy
Condition: infection
Age Group: 61 years
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
Aplastic anemia grade 4, 1 patient
Disc. AE
1 g 1 times / day multiple, intramuscular
Recommended
Dose: 1 g, 1 times / day
Route: intramuscular
Route: multiple
Dose: 1 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
unhealthy, 68 years
n = 1
Health Status: unhealthy
Condition: infection
Age Group: 68 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
Aplastic anemia grade 5, 1 patient
Disc. AE
2 g 1 times / day multiple, parenteral
Recommended
Dose: 2 g, 1 times / day
Route: parenteral
Route: multiple
Dose: 2 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
unhealthy, 71 years
n = 1
Health Status: unhealthy
Condition: infection
Age Group: 71 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/3055188/
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
inhibitor
1587
inhibitor
1852

OverviewOther

Other InhibitorOther SubstrateOther Inducer
CYP1A
72

CYP2A6
707

CYP2B6
810

CYP2C19
1478

CYP2E1
882

CYP2C8/9
44
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
CYP2D6
1891
 no [IC50 375.9 uM]
CYP1A
121
 no
CYP2A6
739
 no
CYP2B6
1001
 no
CYP2C8/9
44
 no
CYP2E1
970
 no
CYP2C19
1553
 yes [IC50 32 uM]
CYP3A4
1925
 yes [IC50 48.1 uM]
Sourcing

Sourcing

Vendor/AggregatorIDURL
3B Scientific (Wuhan) Corp
3B2-0144
http://www.3bsc.com/index/pro_info.php?id=19500
3B Scientific (Wuhan) Corp
3B1-01359
http://www.3bsc.com/index/pro_info.php?id=21571
3B Scientific (Wuhan) Corp
3B1-01423
http://www.3bsc.com/index/pro_info.php?id=21635
AHH Chemical co.,ltd
API-1130
http://www.ahhchemical.com/product/API-1130.html
AK Scientific, Inc. (AKSCI)
M163
http://www.aksci.com/item_detail.php?cat=M163
AbMole Bioscience
M4901
http://www.abmole.com/products/chloramphenicol.html
Achemo Scientific Limited
AC-11414
http://www.achemo.com/product_view.asp?ID=1304
Achemtek
0104-014718
http://www.achemtek.com/56-75-7
Acros Organics
AC227920250
https://www.fishersci.com/shop/products/chloramphenicol-98-acros-organics-1/AC227920250
Acros Organics
AC227925000
https://www.fishersci.com/shop/products/chloramphenicol-98-acros-organics-2/AC227925000
Acros Organics
AC227921000
https://www.fishersci.com/shop/products/chloramphenicol-98-acros-organics/AC227921000
Adooq BioScience
A10200
https://www.adooq.com/chloramphenicol.html
Alfa Aesar
B20841
https://www.alfa.com/en/catalog/B20841/
Alfa Chemistry
AP56757-A
https://reagents.alfa-chemistry.com/product/chloramphenicol-cas-56-75-7-13261.html
Alfa Chemistry
AP56757-B
https://reagents.alfa-chemistry.com/product/chloramphenicol-cas-56-75-7-13262.html
Angene
AGN-PC-0SMDXX
http://www.angenechemical.com/productshow/AGN-PC-0SMDXX.html
ApexBio Technology
A2512
http://www.apexbt.com/chloramphenicol.html
Aronis
ARONIS23913
http://www.aronis.ru/store/index.php?main_page=product_info&cPath=1&products_id=1185
Aurora Fine Chemicals LLC
K04.629.929
http://online.aurorafinechemicals.com/info?ID=K04.629.929
Aurum Pharmatech LLC
W-2830
http://www.Aurumpharmatech.com/Product/ProductDetails/W_2830
Avantor Inc
200002-782
https://us.vwr.com/store/product/7517958/chloramphenicol
Avantor Inc
101094-576
https://us.vwr.com/store/product/7889372/chloramphenicol
BioChemPartner
BCP12150
http://www.biochempartner.com/56-75-7-BCP12150
BioSynth
C-3307
https://www.biosynth.com/en/products/life-science/culture-media-additives/products/C-3307.html
Calbiochem
220551
http://www.emdbiosciences.com/product/220551
Capot Chemical
20321
http://www.capotchem.com/en/20321.htm
Capot Chemical
PubChem20321
http://www.capotchem.com/en/20321.htm
Chem Scene
CS-2207
http://www.chemscene.com/56-75-7.html
ChemMol
80101190
http://www.chemmol.com/chemmol/80101190.html
ChemMol
99159330
http://www.chemmol.com/chemmol/99159330.html
Chemenu
CM110456
http://www.chemenu.com/products/CM110456
Chemspace
CSSB00000037240
https://chem-space.com/CSSB00000037240
Chiralblock Biosciences
CB11330
http://www.chiralblock.com/products/56-75-7.html
Clearsynth
CS-O-11618
https://www.clearsynth.com/en/CSO11618.html
DC Chemicals
DCAPI1255
http://www.dcchemicals.com//product_show-Chloramphenicol_Chloromycetin_.html
EMD Millipore
220551
http://www.emdbiosciences.com/product/220551
Glentham Life Sciences
GA0258
http://www.glentham.com/products/product/GA0258/
LGC Standards
DRE-C11120000
https://www.lgcstandards.com/US/en/p/DRE-C11120000
LGC Standards
DRE-L11120000AL
https://www.lgcstandards.com/US/en/p/DRE-L11120000AL
LGC Standards
DRE-XA11120000EA
https://www.lgcstandards.com/US/en/p/DRE-XA11120000EA
LGC Standards
LGCFOR0516.00
https://www.lgcstandards.com/US/en/p/LGCFOR0516.00
LGC Standards
MM0516.00
https://www.lgcstandards.com/US/en/p/MM0516.00
Lab Network
LN00159574
https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00159574
Matrix Scientific
58319
https://www.matrixscientific.com/058319.html
MedChem Express
HY-B0239
https://www.medchemexpress.com/Chloramphenicol.html
MuseChem
A001107
https://www.musechem.com/product/A001107.html
MuseChem
M114534
https://www.musechem.com/product/M114534.html
Oakwood
492377
http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=193461&ExtHyperLink=1
Sigma-Aldrich
23276_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/23276?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
31667_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/31667?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
75565_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/75565?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
BP854_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/bp854?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
1107004_USP
https://www.sigmaaldrich.com/catalog/product/usp/1107004?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule
S772648
https://www.smolecule.com/products/s772648
Synblock Inc
AB02994
http://www.synblock.com/product/56-75-7.html
TCI (Tokyo Chemical Industry)
C2255
http://www.tcichemicals.com/eshop/en/us/commodity/C2255/index.html
THE BioTek
bt-295295
https://www.thebiotek.com/product/others/bt-295295
THE BioTek
bt-458998
https://www.thebiotek.com/product/others/bt-458998
VladaChem
VL141192
https://www.vladachem.com/product.php?products=56-75-7
abcr GmbH
AB125782
http://www.abcr.com/shop/en/AB125782
eNovation Chemicals
D397703
http://www.enovationchem.com/productDetails.asp?productID=D397703
iChemical
EBD2198129
http://www.ichemical.com/products/56-75-7.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
mcule
MCULE-7778960570
https://mcule.com/MCULE-7778960570/
PubMed

PubMed

TitleDatePubMed
Survey of yeast mastitis in dairy herds of small-type farms in the Lublin region, Poland.
2001
A simple classification method for residual antibiotics using E. coli cells transformed by the calcium chloride method and drug resistance plasmid DNA.
2001
The adverse neuro-developmental effects of postnatal steroids in the preterm infant: a systematic review of RCTs.
2001
Disposition kinetics of florfenicol in goats by using two analytical methods.
2001 Apr
Prevalence of penicillin-resistant Streptococcus pneumoniae in Kuwait.
2001 Apr
Antimicrobial resistance of Streptococcus pneumoniae at a university hospital in Saudi Arabia.
2001 Apr
Randomised controlled trial of ketorolac in the management of corneal abrasions.
2001 Apr
Activity of moxifloxacin against clinical isolates of Streptococcus pneumoniae from England and Wales.
2001 Apr
The epithelial flap for photorefractive keratectomy.
2001 Apr
The Bhaktapur eye study: ocular trauma and antibiotic prophylaxis for the prevention of corneal ulceration in Nepal.
2001 Apr
Sex-related differences in antinociception and tolerance development following chronic intravenous infusion of morphine in the rat: modulatory role of testosterone via morphine clearance.
2001 Apr
An outbreak of Salmonella enteritidis infection in pygmy hogs (Sus salvanius).
2001 Apr
Streptococcus pneumoniae nasopharyngeal carriage prevalence, serotype distribution, and resistance patterns among children on Lombok Island, Indonesia.
2001 Apr 1
Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains.
2001 Apr 27
UV-induced increase in RNA polymerase activity in Xanthomonas oryzae pathovar oryzae.
2001 Aug
Molecular epidemiology of multiple drug resistant type 6B Streptococcus pneumoniae in the Northern Territory and Queensland, Australia.
2001 Feb
Improved high performance liquid chromatographic analysis of omeprazole in human plasma.
2001 Feb
Phenotypic and genotypic characterization of antibiotic-resistant Propionibacterium acnes isolated from acne patients attending dermatology clinics in Europe, the U.S.A., Japan and Australia.
2001 Feb
Vibrio parahaemolyticus associated with cholera-like diarrhea among patients in North Jakarta, Indonesia.
2001 Feb
A limited loss of DNA compaction accompanying the release of cytoplasm from cells of Escherichia coli.
2001 Jan
Inactivation of chloramphenicol by Staphylococcus aureus biotype C from humans & animals.
2001 Jan
Shigella and Salmonella strains isolated from children under 5 years in Gaborone, Botswana, and their antibiotic susceptibility patterns.
2001 Jan
Interaction of human aldehyde dehydrogenase with aromatic substrates and ligands.
2001 Jan 30
Antibacterial activity of 4,5-dihydroxy-2-cyclopentan-1-one (DHCP) and cloning of a gene conferring DHCP resistance in Escherichia coli.
2001 Jul
A novel heat shock protein plays an important role in thermal stress management in cyanobacteria.
2001 Jul 6
Cloning and functional analysis of a phosphopantetheinyl transferase superfamily gene associated with jadomycin biosynthesis in Streptomyces venezuelae ISP5230.
2001 Jun
Distribution of resistance genes tet(M), aph3'-III, catpC194 and the integrase gene of Tn1545 in clinical Streptococcus pneumoniae harbouring erm(B) and mef(A) genes in Spain.
2001 Jun
External quality assessment of antimicrobial susceptibility testing in Europe.
2001 Jun
Screening of antibiotic resistant inhibitors from local plant materials against two different strains of Pseudomonas aeruginosa.
2001 Jun
Analysis of a conserved hydrophobic pocket important for the thermostability of Bacillus pumilus chloramphenicol acetyltransferase (CAT-86).
2001 Mar
Occurrence of the vanA and vanC2/C3 genes in Enterococcus species isolated from poultry sources in Malaysia.
2001 Mar
Antimicrobial susceptibilities of Erysipelothrix rhusiopathiae isolated from pigs with swine erysipelas in Japan, 1988-1998.
2001 Mar
Antimicrobial susceptibility of Listeria monocytogenes isolated from meningoencephalitis in sheep.
2001 Mar
Factors involved in the (near) anoxic survival time of Cerastoderma edule: associated bacteria vs. endogenous fuel.
2001 Mar
Improved agar diffusion method for detecting residual antimicrobial agents.
2001 Mar
Clostridium sordelii corneal ulcer.
2001 Mar-Apr
Induction of complement sensitivity in Escherichia coli by citric acid and low pH.
2001 May
In vitro susceptibility of Vibrio spp. isolated from the environment.
2001 May
High prevalence of carriage of antibiotic-resistant Streptococcus pneumoniae in children in Kampala Uganda.
2001 May
In vitro susceptibility to 15 antibiotics of vibrios isolated from penaeid shrimps in Northwestern Mexico.
2001 May
Carriage of antibiotic-resistant bacteria by healthy children.
2001 May
Comparative study of the influence of melatonin and vitamin E on the surface characteristics of Escherichia coli.
2001 May
Chromate tolerant bacteria isolated from tannery effluent.
2001 May
Neisseria meningitidis with decreased susceptibility to penicillin in Ontario, Canada 1997-2000.
2001 May 1
Clinical prevalence, antimicrobial susceptibility, and geographic resistance patterns of enterococci: results from the SENTRY Antimicrobial Surveillance Program, 1997-1999.
2001 May 15
Methicillin-resistant staphylococci and ofloxacin-resistant bacteria from clinically healthy conjunctivas.
2001 May-Jun
Prevalence of serotypes and molecular epidemiology of Streptococcus pneumoniae strains isolated from children in Beijing, China: identification of two novel multiply-resistant clones.
2001 Spring
Molecular epidemiology and mutations at gyrA and parC genes of ciprofloxacin-resistant Escherichia coli isolates from a Taiwan medical center.
2001 Spring
In vitro activity of 19 antimicrobial agents against enterococci from healthy subjects and hospitalized patients and use of an ace gene probe from Enterococcus faecalis for species identification.
2001 Spring
Variation in clonality and antibiotic-resistance genes among multiresistant Salmonella enterica serotype typhimurium phage-type U302 (MR U302) from humans, animals, and foods.
2001 Spring
Patents

Patents

06492508
7
06630514
7
06962805
7
20010001064
7
JP2001500477A
122
JP2001514931A
24
JP2002540147A
41
JP2002541113A
46
JP2003528821A
36
JP4854084B2
12
JPH00568537A
7
JPH00853368A
7
JPH01213569A
7
JPH06199672A
7
JPH0649010A
7
JPH0853329A
8
JPH0853368A
7
JPH09132532A
12
JPH10323181A
7
JPS05955897A
7
JPS57163499A
7
JPS57166995A
10
JPS58118599A
7
JPS59179080A
7
JPS6037982A
7

Sample Use Guides

In Vivo Use Guide
Chloramphenicol 0.5% Eye Drops
Route of Administration: Topical
In Vitro Use Guide
The highest activity of chloramphenicol was documented for isolates of Stenotrophomonas maltophilia (76,5 % susceptible, MIC50 = 4 mg/L, MIC90 = 16 mg/L) and of Staphylococcus aureus (76,2 % susceptible, MIC50 = 8 mg/L, MIC90 = 16 mg/L).
Substance Class Chemical
Created
by admin
on Fri Dec 15 20:14:17 GMT 2023
Edited
by admin
on Fri Dec 15 20:14:17 GMT 2023
Record UNII
0IQ3P295UA
Record Status Validated (UNII)
Record Version
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Name Type Language
CHLORAMPHENICOL ARGININE SUCCINATE
Common Name English
L-ARGININE, MONO((2R,3R)-2-((DICHLOROACETYL)AMINO)-3-HYDROXY-3-(4-NITROPHENYL)PROPYL BUTANEDIOATE)
Common Name English
BUTANEDIOIC ACID, MONO((2R,3R)-2-((DICHLOROACETYL)AMINO)-3-HYDROXY-3-(4-NITROPHENYL)PROPYL) ESTER, COMPD. WITH L-ARGININE (1:1)
Common Name English
CHLORAMPHENICOL MONOSUCCINATE ARGININE SALT
MI  
Common Name English
PARAXIN SUCCINATE A
Brand Name English
CHLORAMPHENICOL SUCCINATE L-ARGININE SALT
Common Name English
BUTANEDIOIC ACID, MONO(2-((DICHLOROACETYL)AMINO)-3-HYDROXY-3-(4-NITROPHENYL)PROPYL) ESTER, (R-(R*,R*))-, COMPD. WITH L-ARGININE (1:1)
Common Name English
SUCCINIC ACID, .ALPHA.-MONOESTER WITH D-THREO-(-)-2,2-DICHLORO-N-(.BETA.-HYDROXY-.ALPHA.-(HYDROXYMETHYL)-P-NITROPHENETHYL)ACETAMIDE, COMPD. WITH L-ARGININE (1:1)
Common Name English
CHLORAMPHENICOL MONOSUCCINATE ARGININE SALT [MI]
Common Name English
L-ARGININE, MONO((R-(R*,R*))-2-((DICHLOROACETYL)AMINO)-3-HYDROXY-3-(4-NITROPHENYL)PROPYL BUTANEDIOATE)
Common Name English
Code System Code Type Description
EPA CompTox
DTXSID30187893
Created by admin on Fri Dec 15 20:14:17 GMT 2023 , Edited by admin on Fri Dec 15 20:14:17 GMT 2023
PRIMARY
FDA UNII
0IQ3P295UA
Created by admin on Fri Dec 15 20:14:17 GMT 2023 , Edited by admin on Fri Dec 15 20:14:17 GMT 2023
PRIMARY
CAS
34327-18-9
Created by admin on Fri Dec 15 20:14:17 GMT 2023 , Edited by admin on Fri Dec 15 20:14:17 GMT 2023
PRIMARY
PUBCHEM
71587121
Created by admin on Fri Dec 15 20:14:17 GMT 2023 , Edited by admin on Fri Dec 15 20:14:17 GMT 2023
PRIMARY
MERCK INDEX
m3347
Created by admin on Fri Dec 15 20:14:17 GMT 2023 , Edited by admin on Fri Dec 15 20:14:17 GMT 2023
PRIMARY Merck Index
Related Record Type Details
Structure of CHLORAMPHENICOL
ACTIVE MOIETY
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