INOTERSEN

Approval Year

Substance Class	Nucleic Acid
Nucleic Acid Type	OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	0IEO0F56LV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

INOTERSEN

Official Name

English

INOTERSEN [MI]

Common Name

English

Inotersen [WHO-DD]

Common Name

English

inotersen [INN]

Common Name

English

ISIS-420915

Code

English

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Classification Tree

Code System

Code

Designated/Approved

FDA ORPHAN DRUG

374512

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Code System

Code

Type

Description

RXCUI

2099289

PRIMARY

CAS

1492984-65-2

PRIMARY

WIKIPEDIA

Inotersen

PRIMARY

DRUG CENTRAL

5319

PRIMARY

INN

10294

PRIMARY

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Subunit 0

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Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_6-1_15	10 / 20
2'-O-Methoxyethyl ribose	1_1-1_5;1_16-1_20	10 / 20

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Linkage	Site Range	Site Count
Phosporothioate	1_2-1_20	19 / 19

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TRANSTHYRETIN V30M

TARGET->INHIBITOR OF EXPRESSION


					2COU0B578R

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					0IEO0F56LV

INOTERSEN

ACTIVE MOIETY

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Structural Modifications

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Modification Type	Location Site	Residue Modified	Fragment Name	Fragment Approval
NUCLEOSIDE SUBSTITUTION	[1_2] [1_18] [1_19] [1_20]	C	2'-O-(2-METHOXYETHYL)-5-METHYLCYTIDINE	AOQ54IZZ6J
NUCLEOSIDE SUBSTITUTION	[1_10]	C	5-METHYLDEOXYCYTIDINE	B200GV71QM
NUCLEOSIDE SUBSTITUTION	[1_1] [1_3] [1_4] [1_17]	U	2'-O-(2-METHOXYETHYL)-5-METHYLURIDINE	9Q36I4D9VB

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