U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C8H12N2O2
Molecular Weight 168.1931
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 2
Charge 0

SHOW SMILES / InChI
Structure of HEXAMETHYLENE DIISOCYANATE

SMILES

O=C=NCCCCCCN=C=O

InChI

InChIKey=RRAMGCGOFNQTLD-UHFFFAOYSA-N
InChI=1S/C8H12N2O2/c11-7-9-5-3-1-2-4-6-10-8-12/h1-6H2

HIDE SMILES / InChI

Molecular Formula C8H12N2O2
Molecular Weight 168.1931
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 2
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Synthesis of beta-cyclodextrin and starch based polymers for sorption of azo dyes from aqueous solutions.
2008-02
Transport behavior of n-alkane penetrants into castor oil based polyurethane-polyester nonwoven fabric composites.
2007-06-25
The effect of monomers on the formulation of polymeric nanocapsules based on polyureas and polyamides.
2007-04-20
Isosteric heats of sorption of 1-naphthol and phenol from aqueous solutions by beta-cyclodextrin polymers.
2007-03-01
New biodegradable thermogelling copolymers having very low gelation concentrations.
2007-02
Determination of pulmonary irritant threshold concentrations of hexamethylene-1,6-diisocyanate (HDI) prepolymers by bronchoalveolar lavage in acute rat inhalation studies according to TRGS 430.
2007-02
Cytokeratin autoantibodies: useful serologic markers for toluene diisocyanate-induced asthma.
2006-12-31
Diisocyanate asthma and gene-environment interactions with IL4RA, CD-14, and IL-13 genes.
2006-12
Evaluation of antibody binding to diisocyanate protein conjugates in a general population.
2006-09
Modeling dermal exposure--an illustration for spray painting applications.
2006-09
Dermal, inhalation, and internal exposure to 1,6-HDI and its oligomers in car body repair shop workers and industrial spray painters.
2006-09
Subacute inhalation exposure of rats to 1,6-hexamethylene diisocyanate with recovery period.
2006-08
Assessing isocyanate exposures in polyurethane industry sectors using biological and air monitoring methods.
2006-08
Tape-strip sampling for measuring dermal exposure to 1,6-hexamethylene diisocyanate.
2006-06
Circulating autoantibodies in patients with aspirin-intolerant asthma: an epiphenomenon related to airway inflammation.
2006-06
Determination of airborne isocyanates generated during the thermal degradation of car paint in body repair shops.
2006-06
Airborne hexamethylene diisocyanate and particulate matter exposures during fire/rescue vehicle ladder finishing operations.
2006-03
PEO-PPO-PEO-based poly(ether ester urethane)s as degradable reverse thermo-responsive multiblock copolymers.
2006-03
Materials for peripheral nerve regeneration.
2006-01-05
Polycondensation of dicarboxylic acids and diols in water catalyzed by surfactant-combined catalysts and successive chain extension.
2006-01
The human macrophage response during differentiation and biodegradation on polycarbonate-based polyurethanes: dependence on hard segment chemistry.
2005-12
Application of cross-linked beta-cyclodextrin polymer for adsorption of aromatic amino acids.
2005-11-03
Poly(ester urethane)s consisting of poly[(R)-3-hydroxybutyrate] and poly(ethylene glycol) as candidate biomaterials: characterization and mechanical property study.
2005-09-13
Chemical analysis of 2,4-toluene diisocyanate, 1,6-hexamethylene diisocyanate and isophorone diisocyanate in petrolatum patch-test preparations.
2005-09
Validation of a solvent-free sampler for the determination of low molecular weight aliphatic isocyanates under thermal degradation conditions.
2005-09
Construction of a biomimetic zwitterionic interface for monitoring cell proliferation and apoptosis.
2005-08-30
Biodegradable cationic PEG-PEI-PBLG hyperbranched block copolymer: synthesis and micelle characterization.
2005-07
DNA strand breaks in the lymphocytes of workers exposed to diisocyanates: indications of individual differences in susceptibility after low-dose and short-term exposure.
2005-06
Chemical modification of poly(vinyl chloride) resin using poly(ethylene glycol) to improve blood compatibility.
2005-06
Gene expression profiling in mouse lung following polymeric hexamethylene diisocyanate exposure.
2005-05-15
Designing biodegradable multiblock PCL/PLA thermoplastic elastomers.
2005-05
Effect of soft segment length on properties of fluorinated polyurethanes.
2005-04-10
Preparation of ZnO nanoparticles in a reverse micellar system and their photoluminescence properties.
2005-04-01
Solvent-free sampling with di-n-butylamine for monitoring of isocyanates in air.
2005-04
Glutathione protects human airway proteins and epithelial cells from isocyanates.
2005-03
The increase in denaturation temperature following cross-linking of collagen is caused by dehydration of the fibres.
2005-02-18
Quantitative determination of hexamethylene diisocyanate (HDI), 2,4-toluene diisocyanate (2,4-TDI) and 2,6-toluene diisocyanate (2,6-TDI) monomers at ppt levels in air by alkaline adduct coordination ionspray tandem mass spectrometry.
2005-02
Polycarbonate-urethane hard segment type influences esterase substrate specificity for human-macrophage-mediated biodegradation.
2005
Physical, mechanical and degradation properties, and schwann cell affinity of cross-linked chitosan films.
2005
Ferrocenoyl piperazide as derivatizing agent for the analysis of isocyanates and related compounds using liquid chromatography/electrochemistry/mass spectrometry (LC/EC/MS).
2004-12
Chemical graft polymerization of sulfobetaine monomer on polyurethane surface for reduction in platelet adhesion.
2004-11-25
Urinary hexane diamine to assess respiratory exposure to hexamethylene diisocyanate aerosol: a human inhalation study.
2004-10-12
Allergic contact dermatitis from isocyanates among sculptors.
2004-09
Preparation of Y2O3:Eu3+ nanoparticles in reverse micellar systems and their photoluminescence properties.
2004-08-15
Porcine collagen crosslinking, degradation and its capability for fibroblast adhesion and proliferation.
2004-08
Platelet adhesive resistance of polyurethane surface grafted with zwitterions of sulfobetaine.
2004-07-01
Determination of technical grade isocyanates used in the production of polyurethane plastics.
2004-07
Isocyanate vapor-induced antigenicity of human albumin.
2004-06
Cytokine adsorptive property of various adsorbents in immunoadsorption columns and a newly developed adsorbent: an in vitro study.
2004
Surface characterization and platelet adhesion studies of aliphatic polyurethanes grafted by fluorocarbon oligomers: effect of fluorocarbon chain length and carboxylic acid group.
2002-01
Patents
Substance Class Chemical
Created
by admin
on Mon Mar 31 19:08:12 GMT 2025
Edited
by admin
on Mon Mar 31 19:08:12 GMT 2025
Record UNII
0I70A3I1UF
Record Status Validated (UNII)
Record Version
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Name Type Language
HEXAMETHYLENE DIISOCYANATE
HSDB  
Systematic Name English
1,6-HEXAMETHYLENE DIISOCYANATE
INCI  
Preferred Name English
HXT
Common Name English
HEXAMETHYLENE-1,6-DIISOCYANATE
Common Name English
1,6-HEXANE DIISOCYANATE
Common Name English
HEXAMETHYLENE-1,6-DIISOCYANATE (DIISOCYANATES)
Common Name English
S 90
Brand Name English
NSC-11687
Code English
HEXANE 1,6-DIISOCYANATE
Common Name English
HMDI
Common Name English
HEXAMETHYLENEDIISOCYANATE
Systematic Name English
S-90
Brand Name English
HDI
Common Name English
HEXAMETHYLENE DIISOCYANATE, 1,6-
Common Name English
1,6-DIISOCYANATOHEXAMETHYLENE
Common Name English
TL 78
Brand Name English
1,6-HEXAMETHYLENE DI-ISOCYANATE
Common Name English
1,6-HEXYLENE DIISOCYANATE
Systematic Name English
1,6-DIISOCYANATOHEXANE
Systematic Name English
GMDI
Common Name English
HEXAMETHYLENE DIISOCYANATE [HSDB]
Common Name English
ISOCYANIC ACID, HEXAMETHYLENE ESTER
Common Name English
Code System Code Type Description
WIKIPEDIA
HEXAMETHYLENE DIISOCYANATE
Created by admin on Mon Mar 31 19:08:12 GMT 2025 , Edited by admin on Mon Mar 31 19:08:12 GMT 2025
PRIMARY
DAILYMED
0I70A3I1UF
Created by admin on Mon Mar 31 19:08:12 GMT 2025 , Edited by admin on Mon Mar 31 19:08:12 GMT 2025
PRIMARY
CAS
822-06-0
Created by admin on Mon Mar 31 19:08:12 GMT 2025 , Edited by admin on Mon Mar 31 19:08:12 GMT 2025
PRIMARY
CHEBI
53578
Created by admin on Mon Mar 31 19:08:12 GMT 2025 , Edited by admin on Mon Mar 31 19:08:12 GMT 2025
PRIMARY
EPA CompTox
DTXSID4024143
Created by admin on Mon Mar 31 19:08:12 GMT 2025 , Edited by admin on Mon Mar 31 19:08:12 GMT 2025
PRIMARY
PUBCHEM
13192
Created by admin on Mon Mar 31 19:08:12 GMT 2025 , Edited by admin on Mon Mar 31 19:08:12 GMT 2025
PRIMARY
HSDB
6134
Created by admin on Mon Mar 31 19:08:12 GMT 2025 , Edited by admin on Mon Mar 31 19:08:12 GMT 2025
PRIMARY
NSC
11687
Created by admin on Mon Mar 31 19:08:12 GMT 2025 , Edited by admin on Mon Mar 31 19:08:12 GMT 2025
PRIMARY
FDA UNII
0I70A3I1UF
Created by admin on Mon Mar 31 19:08:12 GMT 2025 , Edited by admin on Mon Mar 31 19:08:12 GMT 2025
PRIMARY
CHEBI
53216
Created by admin on Mon Mar 31 19:08:12 GMT 2025 , Edited by admin on Mon Mar 31 19:08:12 GMT 2025
PRIMARY
ECHA (EC/EINECS)
212-485-8
Created by admin on Mon Mar 31 19:08:12 GMT 2025 , Edited by admin on Mon Mar 31 19:08:12 GMT 2025
PRIMARY
RXCUI
1428547
Created by admin on Mon Mar 31 19:08:12 GMT 2025 , Edited by admin on Mon Mar 31 19:08:12 GMT 2025
PRIMARY RxNorm