AZX100, a synthetic 24 amino acid peptide, is a cell-permeant peptide that mimics HSP20, bypassing the signaling pathways leading to smooth muscle relaxation. This mechanism of action is particularly important in certain patients, such as asthmatics. AZX100 possesses a mechanism of action called filamentous actin disassembly. AZX100 was studied by Capstone for the treatment of pulmonary fibrosis, the prevention of hypertrophic and keloid scarring and intimal hyperplasia. However, in 2014, Capstone terminated the license agreement for AZX100 intellectual property and returned all interest in and rights to the AZX100 intellectual property to the Licensor (AzTE).
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Internalization and intracellular trafficking of a PTD-conjugated anti-fibrotic peptide, AZX100, in human dermal keloid fibroblasts. | 2010-07 |
|
| Treatment with transducible phosphopeptide analogues of the small heat shock-related protein, HSP20, after experimental subarachnoid hemorrhage: prevention and reversal of delayed decreases in cerebral perfusion. | 2010-03 |
Sample Use Guides
AZX100 Drug Product 3 or 10 mg or placebo (saline) was administered intradermally at each of three trocar sites on each patient 9 ± 2 days and 21 ± 2 days after arthroscopic surgery. The three trocar sites (anterior, lateral, and posterior sides of the shoulder) were randomized to receive the same dose of study agent for both dose administrations.
Route of Administration:
Transdermal
| Substance Class |
Protein
Created
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admin
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Mon Mar 31 21:34:25 GMT 2025
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admin
on
Mon Mar 31 21:34:25 GMT 2025
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| Protein Sub Type | |
| Sequence Type | COMPLETE |
| Record UNII |
0HT093MD6R
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| Record Status |
Validated (UNII)
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| Record Version |
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0HT093MD6R
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DB06323
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1217194-46-1
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admin on Mon Mar 31 21:34:25 GMT 2025 , Edited by admin on Mon Mar 31 21:34:25 GMT 2025
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| AMINO ACID SUBSTITUTION | [1_17] | SERINE |
Amount:
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DEXFOSFOSERINE | VI4F0K069V |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) | CHEMICAL |
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