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AZX100, a synthetic 24 amino acid peptide, is a cell-permeant peptide that mimics HSP20, bypassing the signaling pathways leading to smooth muscle relaxation. This mechanism of action is particularly important in certain patients, such as asthmatics. AZX100 possesses a mechanism of action called filamentous actin disassembly. AZX100 was studied by Capstone for the treatment of pulmonary fibrosis, the prevention of hypertrophic and keloid scarring and intimal hyperplasia. However, in 2014, Capstone terminated the license agreement for AZX100 intellectual property and returned all interest in and rights to the AZX100 intellectual property to the Licensor (AzTE).

Approval Year

PubMed

PubMed

TitleDatePubMed
Internalization and intracellular trafficking of a PTD-conjugated anti-fibrotic peptide, AZX100, in human dermal keloid fibroblasts.
2010 Jul
Treatment with transducible phosphopeptide analogues of the small heat shock-related protein, HSP20, after experimental subarachnoid hemorrhage: prevention and reversal of delayed decreases in cerebral perfusion.
2010 Mar

Sample Use Guides

AZX100 Drug Product 3 or 10 mg or placebo (saline) was administered intradermally at each of three trocar sites on each patient 9 ± 2 days and 21 ± 2 days after arthroscopic surgery. The three trocar sites (anterior, lateral, and posterior sides of the shoulder) were randomized to receive the same dose of study agent for both dose administrations.
Route of Administration: Transdermal
Substance Class Protein
Created
by admin
on Sat Dec 16 05:54:54 GMT 2023
Edited
by admin
on Sat Dec 16 05:54:54 GMT 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
0HT093MD6R
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AZX-100
Common Name English
AZX100
Code English
Code System Code Type Description
FDA UNII
0HT093MD6R
Created by admin on Sat Dec 16 05:54:54 GMT 2023 , Edited by admin on Sat Dec 16 05:54:54 GMT 2023
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DRUG BANK
DB06323
Created by admin on Sat Dec 16 05:54:54 GMT 2023 , Edited by admin on Sat Dec 16 05:54:54 GMT 2023
PRIMARY
CAS
1217194-46-1
Created by admin on Sat Dec 16 05:54:54 GMT 2023 , Edited by admin on Sat Dec 16 05:54:54 GMT 2023
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Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) CHEMICAL