DIDIAVALO

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H22N2
Molecular Weight	278.3914
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(CC(C#N)(C1=CC=CC=C1)C2=CC=CC=C2)N(C)C

InChI

InChIKey=GJJQIGFCGLPOQK-UHFFFAOYSA-N

InChI=1S/C19H22N2/c1-16(21(2)3)14-19(15-20,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-13,16H,14H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C19H22N2
Molecular Weight	278.3914
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://pubs.acs.org/doi/abs/10.1021/ja01193a509 | https://www.ncbi.nlm.nih.gov/pubmed/20239733

Didiavalo (premethadone) is a methadone analog and precursor. Didiavalo possesses analgetic properties with the effective dose in rats 30 times higher than the analgesic dose of morphine.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20239733	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

To study the analgetic effect of didiavalo the drug was administered to rats intravenously. Didiavalo was 30 times less potent than morphine, with effects of dose 60 mg/kg similar to the effect of 2.0 mg/kg morphine.

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:14:49 GMT 2023` Edited by `admin` on `Fri Dec 15 15:14:49 GMT 2023`
Record UNII	0GYB2HJA89
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DIDIAVALO

Common Name

English

4-(DIMETHYLAMINO)-2,2-DIPHENYLVALERONITRILE

Systematic Name

English

DIDIAVALO, (±)-

Common Name

English

METHADONE HYDROCHLORIDE IMPURITY B [EP IMPURITY]

Common Name

English

LEVOMETHADONE HYDROCHLORIDE IMPURITY B [EP IMPURITY]

Common Name

English

BENZENEACETONITRILE, .ALPHA.-(2-(DIMETHYLAMINO)PROPYL)-.ALPHA.-PHENYL-

Systematic Name

English

NSC-50382

Code

English

IDS-NM-003

Code

English

2,2-DIPHENYL-4-(DIMETHYLAMINO)VALERONITRILE

Systematic Name

English

(4RS)-4-(DIMETHYLAMINO)-2,2-DIPHENYLPENTANENITRILE

Systematic Name

English

METHADONE INTERMEDIATE

Common Name

English

NSC-2089

Code

English

PREMETHADONE

Common Name

English

METHADONE-INTERMEDIATE, 4-CYANO-2-DIMETHYLAMINO-4,4-DIPHENYL BUTANE

Common Name

English

4-CYANO-2-DIMETHYLAMINO-4,4-DIPHENYL BUTANE

Systematic Name

English

Classification Tree Code System Code

DEA NO.

9254