U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 15:55:43 GMT 2023
Edited
by admin
on Sat Dec 16 15:55:43 GMT 2023
Protein Type VIRAL STRUCTURAL PROTEIN
Protein Sub Type VIRAL ENVELOPE PROTEIN
Sequence Origin VIRAL
Sequence Type COMPLETE
Record UNII
0EO1SV3LKY
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SPIKE-1 PROTEIN SARS-COV-2
Common Name English
SARS-COV-2 RECEPTOR BINDING DOMAIN PROTEIN
Common Name English
SARS-COV-2 SPIKE-1 PROTEIN
Common Name English
Code System Code Type Description
UNIPROT
P0DTC2
Created by admin on Sat Dec 16 15:55:43 GMT 2023 , Edited by admin on Sat Dec 16 15:55:43 GMT 2023
PRIMARY
FDA UNII
0EO1SV3LKY
Created by admin on Sat Dec 16 15:55:43 GMT 2023 , Edited by admin on Sat Dec 16 15:55:43 GMT 2023
PRIMARY
From To
1_3 1_124
1_119 1_154
1_279 1_289
1_324 1_349
1_367 1_420
1_379 1_513
1_526 1_578
1_605 1_637
1_650 1_659
2_3 2_124
2_119 2_154
2_279 2_289
2_324 2_349
2_367 2_420
2_379 2_513
2_526 2_578
2_605 2_637
2_650 2_659
3_3 3_124
3_119 3_154
3_279 3_289
3_324 3_349
3_367 3_420
3_379 3_513
3_526 3_578
3_605 3_637
3_650 3_659
Glycosylation Link Type Site
N 1_5
N 1_49
N 1_62
N 1_110
N 1_137
N 1_153
N 1_222
N 1_270
N 1_319
N 1_331
N 1_591
N 1_604
N 1_645
N 2_5
N 2_49
N 2_62
N 2_110
N 2_137
N 2_153
N 2_222
N 2_270
N 2_319
N 2_331
N 2_591
N 2_604
N 2_645
N 3_5
N 3_49
N 3_62
N 3_110
N 3_137
N 3_153
N 3_222
N 3_270
N 3_319
N 3_331
N 3_591
N 3_604
N 3_645
Related Record Type Details
INHIBITOR -> TARGET
INHIBITOR -> TARGET
In blocking studies, REGN10933, REGN10987, and REGN-COV2 mediated concentration-dependent blockade of SARS-CoV-2 RBD binding to human ACE2 with IC50 values in the subnanomolar range.
IN-VITRO
IC50
INHIBITOR -> TARGET
LIGAND->TARGET
Blocks attachment of the virus to human angiotensin-converting enzyme 2 (ACE2) receptors, preventing subsequent viral entry into human cells and viral replication.
INHIBITOR -> TARGET
IN-VITRO
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL