RITOLUKAST

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H13F3N2O3S
Molecular Weight	382.357
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC(F)(F)S(=O)(=O)NC1=CC=CC(OCC2=CC=C3C=CC=CC3=N2)=C1

InChI

InChIKey=GOHUJGMYCZDYDF-UHFFFAOYSA-N

InChI=1S/C17H13F3N2O3S/c18-17(19,20)26(23,24)22-13-5-3-6-15(10-13)25-11-14-9-8-12-4-1-2-7-16(12)21-14/h1-10,22H,11H2

HIDE SMILES / InChI

Molecular Formula	C17H13F3N2O3S
Molecular Weight	382.357
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2731997 | https://adisinsight.springer.com/drugs/800000065 | https://www.ncbi.nlm.nih.gov/pubmed/2454830

Ritolukast (WY 48252) is an aerosol leukotriene D4 (LTD4) receptor antagonist. This orally administered drug was developed for use in treatment of asthma. Ritolukast was shown to prevent and reverse bronchoconstriction produced by aerosol LTD4 in guinea pigs. This drug also inhibited the synthesis of eicosanoids in rats and was therefore concluded to have modulatory effects on the arachidonic acid metabolism.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cysteinyl leukotriene receptor 1 18 Target ID: Q2NNR5 Gene ID: 1.00135512E8 Gene Symbol: CYSLTR1 Target Organism: Cavia porcellus (Guinea pig) Sources: https://www.ncbi.nlm.nih.gov/pubmed/2780767 \| https://www.ncbi.nlm.nih.gov/pubmed/2498516 \| https://www.ncbi.nlm.nih.gov/pubmed/2543033	Antagonist 2849

Substance Class	Chemical Created by `admin` on `Wed Apr 02 08:29:03 GMT 2025` Edited by `admin` on `Wed Apr 02 08:29:03 GMT 2025`
Record UNII	0E8R4GDE2Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

WY-48252

Preferred Name

English

RITOLUKAST

Official Name

English

RITOLUKAST [USAN]

Common Name

English

ritolukast [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29712