TERBEQUINIL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H18N2O3
Molecular Weight	274.315
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCNC(=O)C1=CN(COC)C2=C(C=CC=C2)C1=O

InChI

InChIKey=RIPDGZHPNKQLDC-UHFFFAOYSA-N

InChI=1S/C15H18N2O3/c1-3-8-16-15(19)12-9-17(10-20-2)13-7-5-4-6-11(13)14(12)18/h4-7,9H,3,8,10H2,1-2H3,(H,16,19)

HIDE SMILES / InChI

Molecular Formula	C15H18N2O3
Molecular Weight	274.315
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8091361 | https://adisinsight.springer.com/drugs/800006144

Terbequinil (previously known as SR 25776), a nootropic agent, is a partial inverse agonist of benzodiazepine receptor with psychostimulant activity. This drug participated in clinical trials for the treatment of cognition disorders and major depressive disorder. However, the development of terbequinil was discontinued during clinical trials in France.

Originator

Approval Year

PubMed

Title	Date	PubMed
Cognitive impairments induced by triazolam in healthy volunteers: antagonism by a partial inverse agonist of benzodiazepine receptor.	1994 Jan-Feb	8091361

Sample Use Guides

In Vivo Use Guide

The effects of SR 25776 (TERBEQUINIL) 500 mg alone and in combination with triazolam 0.25 mg on psychomotor performance and memory were assessed in 8 healthy consenting male volunteers in a double-blind placebo controlled trial

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:50:54 GMT 2023` Edited by `admin` on `Fri Dec 15 15:50:54 GMT 2023`
Record UNII	0DH9WUS03O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TERBEQUINIL

Official Name

English

terbequinil [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29710