TELAZORLIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 23:31:23 GMT 2025` Edited by `admin` on `Tue Apr 01 23:31:23 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	0CRN540O4R
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

telazorlimab [INN]

Preferred Name

English

TELAZORLIMAB

Official Name

English

ISB-830

Code

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN CD134 ANTIGEN) (HUMAN-MUS MUSCULUS MONOCLONAL GBR 830 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL GBR 830 .KAPPA.-CHAIN, DIMER

Systematic Name

English

Telazorlimab [WHO-DD]

Common Name

English

HUMANIZED MONOCLONAL ANTIBODY ISB 830

Common Name

English

ISB 830

Code

English

GBR830

Code

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN CD134 ANTIGEN) (HUMAN-MUS MUSCULUS MONOCLONAL ISB 830 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL ISB 830 .KAPPA.-CHAIN, DIMER

Systematic Name

English

GBR-830

Code

English

HUMANIZED, IMMUNOGLOBIN G1(IGG1) ANTIBODY SPECIFIC FOR OX40 (CD134)

Common Name

English

GBR 830

Code

English

Code System Code Type Description

CAS

2126777-87-3

Created by admin on Tue Apr 01 23:31:23 GMT 2025 , Edited by admin on Tue Apr 01 23:31:23 GMT 2025

PRIMARY

SMS_ID

300000024133

Created by admin on Tue Apr 01 23:31:23 GMT 2025 , Edited by admin on Tue Apr 01 23:31:23 GMT 2025

PRIMARY

NCI_THESAURUS

C175859

Created by admin on Tue Apr 01 23:31:23 GMT 2025 , Edited by admin on Tue Apr 01 23:31:23 GMT 2025

PRIMARY

CAS

2243173-08-0

Created by admin on Tue Apr 01 23:31:23 GMT 2025 , Edited by admin on Tue Apr 01 23:31:23 GMT 2025

SUPERSEDED

FDA UNII

0CRN540O4R

Created by admin on Tue Apr 01 23:31:23 GMT 2025 , Edited by admin on Tue Apr 01 23:31:23 GMT 2025

PRIMARY

INN

11273

Created by admin on Tue Apr 01 23:31:23 GMT 2025 , Edited by admin on Tue Apr 01 23:31:23 GMT 2025

PRIMARY

From	To
1_22	1_97
2_22	2_97
2_145	2_201
2_221	4_213
2_262	2_322
1_145	1_201
2_368	2_426
3_23	3_87
3_133	3_193
4_23	4_87
4_133	4_193
1_221	3_213
1_227	2_227
1_230	2_230
1_262	1_322
1_368	1_426

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details


					115VXA358P

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 4

TARGET -> INHIBITOR

Related Record Type Details


					0CRN540O4R

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_448] [2_448]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL