LOFEMIZOLE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H9ClN2.ClH
Molecular Weight	229.106
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC1=C(N=CN1)C2=CC=C(Cl)C=C2

InChI

InChIKey=PIAMNHTVFPWVHG-UHFFFAOYSA-N

InChI=1S/C10H9ClN2.ClH/c1-7-10(13-6-12-7)8-2-4-9(11)5-3-8;/h2-6H,1H3,(H,12,13);1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C10H9ClN2
Molecular Weight	192.645
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6501522 | https://www.google.com/patents/US20010023254

Lofemizole is a non-steroidal anti-inflammatory drug. Lofemizole has proved to possess an interesting antiphlogistic activity in both animals and humans, associated with a favorable gastric and systemic tolerability.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Inflammation 102 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6501522 https://www.google.com/patents/US20010023254	Primary		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Gas--liquid chromatographic evaluation of lofemizole in biological samples for pharmacokinetic investigations. Comparison of two analytical methods.	1984 Sep 14	6501522

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:11:41 GMT 2023` Edited by `admin` on `Fri Dec 15 16:11:41 GMT 2023`
Record UNII	0C2796D6SB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LOFEMIZOLE HYDROCHLORIDE

Official Name

English

1H-IMIDAZOLE, 4-(4-CHLOROPHENYL)-5-METHYL-, MONOHYDROCHLORIDE

Common Name

English

LOFEMIZOLE HCL

Common Name

English

4-(P-CHLOROPHENYL)-5-METHYLIMIDAZOLE MONOHYDROCHLORIDE

Common Name

English

LOFEMIZOLE HYDROCHLORIDE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257