Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H12O5 |
| Molecular Weight | 284.2635 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=C(C=C1O)C2=COC3=C(C=CC(O)=C3)C2=O
InChI
InChIKey=ZZAJQOPSWWVMBI-UHFFFAOYSA-N
InChI=1S/C16H12O5/c1-20-14-5-2-9(6-13(14)18)12-8-21-15-7-10(17)3-4-11(15)16(12)19/h2-8,17-18H,1H3
| Molecular Formula | C16H12O5 |
| Molecular Weight | 284.2635 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Regioselective glucuronidation of the isoflavone calycosin by human liver microsomes and recombinant human UDP-glucuronosyltransferases. | 2014-09-05 |
|
| Profiling of hepatocellular carcinoma cell cycle regulating genes targeted by calycosin. | 2013 |
|
| Flavonoids from Radix Astragali induce the expression of erythropoietin in cultured cells: a signaling mediated via the accumulation of hypoxia-inducible factor-1α. | 2011-03-09 |
|
| Structural relationship and binding mechanisms of five flavonoids with bovine serum albumin. | 2010-12-09 |
|
| [Simultaneous assay of four isoflavonoids in Astragali Radix by QAMS]. | 2010-10 |
|
| [Simultaneous determination of nine isoflavonoids in Huangqi Gegen decoction by high performance liquid chromatography]. | 2010-10 |
|
| Yeast α-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose. | 2010-09-22 |
|
| Isoflavones isolated from red clover (Trifolium pratense) inhibit smooth muscle contraction of the isolated rat prostate gland. | 2010-09 |
|
| The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity. | 2010-08-24 |
|
| Calycosin promotes angiogenesis involving estrogen receptor and mitogen-activated protein kinase (MAPK) signaling pathway in zebrafish and HUVEC. | 2010-07-29 |
|
| New flavonoids with 2BS cell proliferation promoting effect from the seeds of Trigonella foenum-graecum L. | 2010-07 |
|
| Study on the relevance between beany flavor and main bioactive components in Radix Astragali. | 2010-05-12 |
|
| Ligustilide suppresses the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composed of radix astragali and radix angelica sinensis. | 2010-03 |
|
| Comparison of the immunoregulatory function of different constituents in radix astragali and radix hedysari. | 2010 |
|
| [Isoflavones from vines of Pueraria lobata]. | 2009-12 |
|
| Stimulating effects of Bacillus subtilis natto-fermented Radix astragali on hyaluronic acid production in human skin cells. | 2009-09-25 |
|
| Microsomal metabolism of calycosin, formononetin and drug-drug interactions by dynamic microdialysis sampling and HPLC-DAD-MS analysis. | 2009-08-15 |
|
| [Constituents of Millettia nitida var. hirsutissima]. | 2009-08 |
|
| An updated review of tyrosinase inhibitors. | 2009-05-26 |
|
| Protection of PC12 cells against superoxide-induced damage by isoflavonoids from Astragalus mongholicus. | 2009-02 |
|
| Inhibitory effects of calycosin isolated from the root of Astragalus membranaceus on melanin biosynthesis. | 2009-02 |
|
| Determination of two metabolites of calycosin-7-O-beta-D-glucopyranoside in rat urine by HPLC. | 2009-01 |
|
| Protective effect of isoflavones from Trifolium pratense on dopaminergic neurons. | 2008-10 |
|
| Isoflavonoid composition of a callus culture of the relict tree Maackia amurensis Rupr. et Maxim. | 2008-08-27 |
|
| Chemical markers for the quality control of herbal medicines: an overview. | 2008-06-28 |
|
| Chemical comparison and classification of Radix Astragali by determination of isoflavonoids and astragalosides. | 2008-06-09 |
|
| Determination of nine active components in Radix Hedysari and Radix Astragali using capillary HPLC with diode array detection and MS detection. | 2008-02 |
|
| NMR spectral assignments of a new [C--O--C] isoflavone dimer from Andira surinamensis. | 2008-01 |
|
| Phenylalanine ammonia lyase functions as a switch directly controlling the accumulation of calycosin and calycosin-7-O-beta-D-glucoside in Astragalus membranaceus var. mongholicus plants. | 2008 |
|
| Verification of the formulation and efficacy of Danggui Buxue Tang (a decoction of Radix Astragali and Radix Angelicae Sinensis): an exemplifying systematic approach to revealing the complexity of Chinese herbal medicine formulae. | 2007-11-29 |
|
| Combined effects of fangchinoline from Stephania tetrandra Radix and formononetin and calycosin from Astragalus membranaceus Radix on hyperglycemia and hypoinsulinemia in streptozotocin-diabetic mice. | 2007-11 |
|
| Characterization of flavonoids in the extract of Sophora flavescens Ait. by high-performance liquid chromatography coupled with diode-array detector and electrospray ionization mass spectrometry. | 2007-09-03 |
|
| Accumulation of calycosin and its 7-O-beta-D-glucoside and related gene expression in seedlings of Astragalus membranaceus Bge. var. mongholicus (Bge.) Hsiao induced by low temperature stress. | 2007-07 |
|
| Analysis of interaction property of bioactive components in Danggui Buxue Decoction with protein by microdialysis coupled with HPLC-DAD-MS. | 2007-06-01 |
|
| Quality evaluation of Radix Astragali through a simultaneous determination of six major active isoflavonoids and four main saponins by high-performance liquid chromatography coupled with diode array and evaporative light scattering detectors. | 2006-11-17 |
|
| [Simultaneous determination of five isoflavonoids in commercial Radix Astragali by high performance liquid chromatography]. | 2006-09 |
|
| Screening and identification of permeable components in a combined prescription of Danggui Buxue decoction using a liposome equilibrium dialysis system followed by HPLC and LC-MS. | 2006-09 |
|
| Calcium channel blocking activity of calycosin, a major active component of Astragali Radix, on rat aorta. | 2006-08 |
|
| Solvent effect in 1H NMR spectra of 3'-hydroxy-4'-methoxy isoflavonoids from Astragalus membranaceus var. mongholicus. | 2006-07 |
|
| Absorption and metabolism of Astragali radix decoction: in silico, in vitro, and a case study in vivo. | 2006-06 |
|
| Live cell extraction and HPLC-MS analysis for predicting bioactive components of traditional Chinese medicines. | 2006-05-03 |
|
| Chemical and biological assessment of a chinese herbal decoction containing Radix Astragali and Radix Angelicae Sinensis: Determination of drug ratio in having optimized properties. | 2006-04-05 |
|
| Determination of isoflavones in dietary supplements containing soy, Red Clover and kudzu: extraction followed by basic or acid hydrolysis. | 2006-02-24 |
|
| Determination of seven compounds in Tang Maikang granule by high-performance liquid chromatography. | 2006-01-28 |
|
| Isoflavonoids and other compounds from Psorothamnus arborescens with antiprotozoal activities. | 2006-01 |
|
| Astrapterocarpan isolated from Astragalus membranaceus inhibits proliferation of vascular smooth muscle cells. | 2005-11-21 |
|
| Studies of chemical constituents and their antioxidant activities from Astragalus mongholicus Bunge. | 2005-10 |
|
| [Preparative isolation and purification of calycosin and formononetin from Astragalus membranaceus Bge. var. mongholicus (Bge.) Hsiao by high-speed counter-current chromatography]. | 2005-05 |
|
| Capillary liquid chromatography-microcoil 1H nuclear magnetic resonance spectroscopy and liquid chromatography-ion trap mass spectrometry for on-line structure elucidation of isoflavones in Radix astragali. | 2005-03-04 |
|
| [Studies on chromatography fingerprint of huangqi by HPLC]. | 2004-11 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:29:00 GMT 2025
by
admin
on
Mon Mar 31 19:29:00 GMT 2025
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| Record UNII |
09N3E8P7TA
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| Record Status |
Validated (UNII)
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| Record Version |
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77992
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DTXSID70174580
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8109
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C121707
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CALYCOSIN
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