| Stereochemistry | ACHIRAL |
| Molecular Formula | C24H26FN3O2.ClH |
| Molecular Weight | 443.941 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.COC1=CC2=C(C=CC=C2N3CCN(CCNC(=O)C4=CC=C(F)C=C4)CC3)C=C1
InChI
InChIKey=HWLZKPKZVOLFGK-UHFFFAOYSA-N
InChI=1S/C24H26FN3O2.ClH/c1-30-21-10-7-18-3-2-4-23(22(18)17-21)28-15-13-27(14-16-28)12-11-26-24(29)19-5-8-20(25)9-6-19;/h2-10,17H,11-16H2,1H3,(H,26,29);1H
| Molecular Formula | C24H26FN3O2 |
| Molecular Weight | 407.4805 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
S-14506 was originally identified and developed in France by Scientists at the Institut de Recherches Servier. S-14506 showed potent binding and antagonistic activity against the 5HT1-A receptor. It was found to work synergistically with D2 receptor antagonists and was therefore studied in animal models for depression, psychosis, and anxiety. A tritium labeled version was also studied as a potential 5HT1-A receptor PET imaging agent.
CNS Activity
Originator
Approval Year
PubMed
Sample Use Guides
In an in vivo radiolabeling study, [3H]-labeled S-14506 was delivered to mice by caudal vein injection (5 seconds) in a solution of 0.9% NaCl supplemented with 0.05% bovine serum albumin (36-40 ~microCi/ml). Mice were later sacrificed to determine tissue accumulations.
Route of Administration:
Intravenous
Adult Sprague-Dawley rats were killed and their brains dissected and homogenized. Membranes were collected by centrifugation and the resuspended pellet was assayed for 5-HT binding. S-14506 was able to inhibit the specific binding of [3H]WAY-100635 to rat hippocampal membranes at nanomolar concentrations.
