Details
Stereochemistry | ACHIRAL |
Molecular Formula | H4P |
Molecular Weight | 35.0055 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 1 |
SHOW SMILES / InChI
SMILES
[PH4+]
InChI
InChIKey=XYFCBTPGUUZFHI-UHFFFAOYSA-O
InChI=1S/H3P/h1H3/p+1
Molecular Formula | H3P |
Molecular Weight | 33.9976 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Phosphine carries the chemical formula of PH3. The concentration of this compound constantly alters in our environment. Phosphine is an important agricultural fumigant with pulmonary and systemic toxicity that is generated on site as a gas given off by moisture coming in contact with solid form aluminum or zinc phosphide (e.g., in grain storage facilities or railway grain transport cars, where bystanders can be exposed). Phosphine also has industrial applications, particularly in the production of microelectronics. Symptoms such as diarrhea, nausea and vomiting, tightness of the chest, cough, headache, and dizziness have been reported in workers exposed intermittently to concentrations up to 35 ppm.
Approval Year
PubMed
Title | Date | PubMed |
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Chromosome rearrangements in fumigant appliers: possible relationship to non-Hodgkin's lymphoma risk. | 1992 May-Jun |
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31Phosphorus magnetic resonance spectroscopy in late-onset Tay-Sachs disease. | 2001 May |
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Association of polymorphic alleles of the calcium-sensing receptor gene with the clinical severity of primary hyperparathyroidism. | 2001 Sep |
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Effects of PHEX antisense in human osteoblast cells. | 2002 Feb |
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Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene. | 2002 Feb |
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Pathogenesis and treatment of renal osteodystrophy. | 2003 |
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Relation of salivary inorganic phosphorus and alkaline phosphatase to the dental caries status in children. | 2003 Dec |
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Calcification mimicking manganese-induced increased signal intensities in T1-weighted MR images in a patient taking herbal medicine: case report. | 2003 Dec |
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Calcimimetic agents and secondary hyperparathyroidism: rationale for use and results from clinical trials. | 2003 Dec |
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Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production. | 2003 Jan 24 |
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A case of oncogenic osteomalacia detected by 111In-pentetreotide total body scan. | 2003 Jul-Aug |
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Calcimimetic agents: review and perspectives. | 2003 Jun |
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Neural damage due to temporal lobe epilepsy: dual-nuclei (proton and phosphorus) magnetic resonance spectroscopy study. | 2004 Feb |
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Electrolyte concentrations in saliva of children aged 6-10 years with Down syndrome. | 2004 Jul |
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Expression of collagen XVIII and MMP-20 in developing teeth and odontogenic tumors. | 2004 Jun |
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Beneficial effect of liver transplantation on bone mineral density in small infants with cholestasis. | 2004 Jun |
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FGF-23 is elevated by chronic hyperphosphatemia. | 2004 Sep |
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A comparison of clinically useful phosphorus binders for patients with chronic kidney failure. | 2004 Sep |
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Major and trace elements in whole blood of phlebotomized patients with porphyria cutanea tarda. | 2005 |
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Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice. | 2005 Dec |
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[Effects of intermittent treatment with sevelamer hydrochloride on parathyroid hyperplasia and vascular calcification in rats with chronic kidney disease]. | 2005 Sep |
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Increased parathyroid hormone gene expression in secondary hyperparathyroidism of experimental uremia is reversed by calcimimetics: correlation with posttranslational modification of the trans acting factor AUF1. | 2006 Jan |
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Functional characteristics of NaS2, a placenta-specific Na+-coupled transporter for sulfate and oxyanions of the micronutrients selenium and chromium. | 2006 Jun-Jul |
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Effects of the administration of corticosterone, parathyroid hormone, or both, and of their withdrawal, on rat bone and cartilage histomorphometric parameters, and on osteoprotegerin and RANKL mRNA expression and proteins. | 2007 Jun |
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Disruption of iron homeostasis increases phosphine toxicity in Caenorhabditis elegans. | 2007 Mar |
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Elevated phosphorus modulates vitamin D receptor-mediated gene expression in human vascular smooth muscle cells. | 2007 Nov |
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Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1alpha-hydroxylase expression in vitro. | 2007 Nov |
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X-ray fluorescence analysis of long-term changes in the levels and distributions of trace elements in the rat brain following mechanical injury. | 2011 Feb |
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Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney. | 2012 Jan |
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Cholestatic presentation of yellow phosphorus poisoning. | 2014 Jan |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:41:18 GMT 2023
by
admin
on
Sat Dec 16 08:41:18 GMT 2023
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Record UNII |
094H06A71I
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Record Status |
Validated (UNII)
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Record Version |
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