U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula H4P
Molecular Weight 35.0055
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 1

SHOW SMILES / InChI
Structure of PHOSPHONIUM CATION

SMILES

[PH4+]

InChI

InChIKey=XYFCBTPGUUZFHI-UHFFFAOYSA-O
InChI=1S/H3P/h1H3/p+1

HIDE SMILES / InChI

Molecular Formula H3P
Molecular Weight 33.9976
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Phosphine carries the chemical formula of PH3. The concentration of this compound constantly alters in our environment. Phosphine is an important agricultural fumigant with pulmonary and systemic toxicity that is generated on site as a gas given off by moisture coming in contact with solid form aluminum or zinc phosphide (e.g., in grain storage facilities or railway grain transport cars, where bystanders can be exposed). Phosphine also has industrial applications, particularly in the production of microelectronics. Symptoms such as diarrhea, nausea and vomiting, tightness of the chest, cough, headache, and dizziness have been reported in workers exposed intermittently to concentrations up to 35 ppm.

Approval Year

PubMed

PubMed

TitleDatePubMed
Chromosome rearrangements in fumigant appliers: possible relationship to non-Hodgkin's lymphoma risk.
1992 May-Jun
31Phosphorus magnetic resonance spectroscopy in late-onset Tay-Sachs disease.
2001 May
Association of polymorphic alleles of the calcium-sensing receptor gene with the clinical severity of primary hyperparathyroidism.
2001 Sep
Effects of PHEX antisense in human osteoblast cells.
2002 Feb
Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene.
2002 Feb
Pathogenesis and treatment of renal osteodystrophy.
2003
Relation of salivary inorganic phosphorus and alkaline phosphatase to the dental caries status in children.
2003 Dec
Calcification mimicking manganese-induced increased signal intensities in T1-weighted MR images in a patient taking herbal medicine: case report.
2003 Dec
Calcimimetic agents and secondary hyperparathyroidism: rationale for use and results from clinical trials.
2003 Dec
Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production.
2003 Jan 24
A case of oncogenic osteomalacia detected by 111In-pentetreotide total body scan.
2003 Jul-Aug
Calcimimetic agents: review and perspectives.
2003 Jun
Neural damage due to temporal lobe epilepsy: dual-nuclei (proton and phosphorus) magnetic resonance spectroscopy study.
2004 Feb
Electrolyte concentrations in saliva of children aged 6-10 years with Down syndrome.
2004 Jul
Expression of collagen XVIII and MMP-20 in developing teeth and odontogenic tumors.
2004 Jun
Beneficial effect of liver transplantation on bone mineral density in small infants with cholestasis.
2004 Jun
FGF-23 is elevated by chronic hyperphosphatemia.
2004 Sep
A comparison of clinically useful phosphorus binders for patients with chronic kidney failure.
2004 Sep
Major and trace elements in whole blood of phlebotomized patients with porphyria cutanea tarda.
2005
Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice.
2005 Dec
[Effects of intermittent treatment with sevelamer hydrochloride on parathyroid hyperplasia and vascular calcification in rats with chronic kidney disease].
2005 Sep
Increased parathyroid hormone gene expression in secondary hyperparathyroidism of experimental uremia is reversed by calcimimetics: correlation with posttranslational modification of the trans acting factor AUF1.
2006 Jan
Functional characteristics of NaS2, a placenta-specific Na+-coupled transporter for sulfate and oxyanions of the micronutrients selenium and chromium.
2006 Jun-Jul
Effects of the administration of corticosterone, parathyroid hormone, or both, and of their withdrawal, on rat bone and cartilage histomorphometric parameters, and on osteoprotegerin and RANKL mRNA expression and proteins.
2007 Jun
Disruption of iron homeostasis increases phosphine toxicity in Caenorhabditis elegans.
2007 Mar
Elevated phosphorus modulates vitamin D receptor-mediated gene expression in human vascular smooth muscle cells.
2007 Nov
Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1alpha-hydroxylase expression in vitro.
2007 Nov
X-ray fluorescence analysis of long-term changes in the levels and distributions of trace elements in the rat brain following mechanical injury.
2011 Feb
Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney.
2012 Jan
Cholestatic presentation of yellow phosphorus poisoning.
2014 Jan
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 16 08:41:18 GMT 2023
Edited
by admin
on Sat Dec 16 08:41:18 GMT 2023
Record UNII
094H06A71I
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PHOSPHONIUM CATION
Common Name English
PHOSPHINE, CONJUGATE ACID
Common Name English
MONO-PHOSPHONIUM
Systematic Name English
PHOSPHONIUM
Systematic Name English
PHOSPHORUS(I) CATION
Common Name English
PHOSPHORUS(1+)
Systematic Name English
PHOSPHORUS CATION
Common Name English
LAMBDA(5)-PHOSPHANE
Common Name English
PHOSPHANIUM
Systematic Name English
TETRAHYDRIDOPHOSPHORUS(1+)
Systematic Name English
PHOSPHORUS(1+) ION
Common Name English
Code System Code Type Description
CHEBI
30282
Created by admin on Sat Dec 16 08:41:18 GMT 2023 , Edited by admin on Sat Dec 16 08:41:18 GMT 2023
PRIMARY
CHEBI
30285
Created by admin on Sat Dec 16 08:41:18 GMT 2023 , Edited by admin on Sat Dec 16 08:41:18 GMT 2023
PRIMARY
PUBCHEM
5460504
Created by admin on Sat Dec 16 08:41:18 GMT 2023 , Edited by admin on Sat Dec 16 08:41:18 GMT 2023
PRIMARY
EPA CompTox
DTXSID50420092
Created by admin on Sat Dec 16 08:41:18 GMT 2023 , Edited by admin on Sat Dec 16 08:41:18 GMT 2023
PRIMARY
CAS
16749-13-6
Created by admin on Sat Dec 16 08:41:18 GMT 2023 , Edited by admin on Sat Dec 16 08:41:18 GMT 2023
PRIMARY
FDA UNII
094H06A71I
Created by admin on Sat Dec 16 08:41:18 GMT 2023 , Edited by admin on Sat Dec 16 08:41:18 GMT 2023
PRIMARY
CHEBI
33467
Created by admin on Sat Dec 16 08:41:18 GMT 2023 , Edited by admin on Sat Dec 16 08:41:18 GMT 2023
PRIMARY