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HUMAN RECOMBINANT BONE MORPHOGENETIC PROTEIN 4
08RQ4CQ601
Investigational
General
Record Details
Names
4
Classification
2
Identifiers
4
Subunits
2
Disulfide Links
7
Glycosylation
4
Relationships
2
Active Moiety
1
Characteristic Attributes
2
HUMAN RECOMBINANT BONE MORPHOGENETIC PROTEIN 4
08RQ4CQ601
Investigational
General
Approval Year
Unknown
149,124
Record Details
Substance Class
Protein
Protein Type
GROWTH FACTOR
Protein Sub Type
Sequence Origin
HUMAN
Sequence Type
COMPLETE
Record UNII
08RQ4CQ601
Record Status
Validated (UNII)
Record Version
9
8
7
6
5
4
3
2
1
Names
4
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entries
Name
Type
Language
Name
Type
Language
HUMAN RECOMBINANT BONE MORPHOGENETIC PROTEIN 4
Common Name
English
HRBMP4
Preferred Name
English
RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN 4
Common Name
English
R-HBMP4
Common Name
English
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Classification
2
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Classification Tree
Code System
Code
Classification Tree
Code System
Code
Positive
EU ORPHAN DRUG
Positive
Treatment of glioma
EU-Orphan Drug
EU/3/14/1348
Designated
ORPHAN DRUG
Designated
Treatment of glioblastoma multiforme.
FDA ORPHAN DRUG
520216
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Identifiers
4
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Code System
Code
Type
Description
Code System
Code
Type
Description
SMS_ID
300000007920
PRIMARY
NCI_THESAURUS
C131018
PRIMARY
FDA UNII
08RQ4CQ601
PRIMARY
WIKIPEDIA
Bone_morphogenetic_protein_4
PRIMARY
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Subunits
2
Subunit 0
>SUBUNIT_0
Subunit 1
>SUBUNIT_1
Disulfide Links
7
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From
To
From
To
1_16
1_81
1_80
2_80
1_45
1_113
1_49
1_115
2_16
2_81
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1
2
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Glycosylation
4
Glycosylation Type
MAMMALIAN
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Glycosylation Link Type
Site
Glycosylation Link Type
Site
N
1_58
N
1_73
N
2_58
N
2_73
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Relationships
2
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Related Record
Type
Details
Related Record
Type
Details
8YD927SYG7
BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
TARGET -> AGONIST
Comments:
Binds to 2 different types of serine-threonine kinase receptors known as BMPR1 and BMPR2.
5L54H526NG
BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-2
TARGET -> AGONIST
Comments:
Able to bind to BMPR2 without BMPR1 however, the affinity significantly increases in the presence of both receptors. BMPR1 is transphosphorylated via BMPR2 which induces downstream signalling within the cell, affecting transcription.
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Active Moiety
1
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Related Record
Type
Details
Related Record
Type
Details
08RQ4CQ601
HUMAN RECOMBINANT BONE MORPHOGENETIC PROTEIN 4
ACTIVE MOIETY
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Characteristic Attributes
2
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entries
Name
Property Type
Amount
Referenced Substance
Defining
Parameters
References
Name
Property Type
Amount
Referenced Substance
Defining
Parameters
References
Molecular Formula
CHEMICAL
ESTIMATED
C1154H1756N328O340S18
MOL_WEIGHT:NUMBER(CALCULATED)
CHEMICAL
ESTIMATED 26300 Da (average)
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