U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C6H8FN3O3
Molecular Weight 189.1444
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLUOROMISONIDAZOLE

SMILES

OC(CF)CN1C=CN=C1[N+]([O-])=O

InChI

InChIKey=HIIJZYSUEJYLMX-UHFFFAOYSA-N
InChI=1S/C6H8FN3O3/c7-3-5(11)4-9-2-1-8-6(9)10(12)13/h1-2,5,11H,3-4H2

HIDE SMILES / InChI

Molecular Formula C6H8FN3O3
Molecular Weight 189.1444
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Fluoromisonidazole (FMISO) is a small, water-soluble molecule with a molecular weight of 189.14 Daltons. It has an octanol:water partition coefficient of 0.41, so that it would be expected to reflect plasma flow as an inert, freely-diffusible tracer immediately after injection, but later images should reflect its tissue partition coefficient in normoxic tissues. Fluoromisonidazole is used as a positron emission tomography (PET) radiotracer for imaging hypoxia when labeled with fluorine-18. It is the most widely used nitroimidazole imaging agent for use as a non-invasive way to localize and quantify hypoxia.

Approval Year

PubMed

PubMed

TitleDatePubMed
Non-invasive MRS in new anticancer drug development.
1992-09-01
Oncogenic transformation systems involving mammalian cells in vitro to determine the relative risks of different treatment modalities.
1984-12
Patents

Patents

Substance Class Chemical
Created
by admin
on Mon Mar 31 22:32:08 GMT 2025
Edited
by admin
on Mon Mar 31 22:32:08 GMT 2025
Record UNII
082285VIDF
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
KU-2210
Preferred Name English
FLUOROMISONIDAZOLE
Common Name English
1H-IMIDAZOLE-1-ETHANOL, .ALPHA.-(FLUOROMETHYL)-2-NITRO-
Systematic Name English
SR-1367
Code English
FMISO
Common Name English
RO-07-0741
Code English
NSC-292930
Code English
Code System Code Type Description
NSC
292930
Created by admin on Mon Mar 31 22:32:08 GMT 2025 , Edited by admin on Mon Mar 31 22:32:08 GMT 2025
PRIMARY
EPA CompTox
DTXSID30875662
Created by admin on Mon Mar 31 22:32:08 GMT 2025 , Edited by admin on Mon Mar 31 22:32:08 GMT 2025
PRIMARY
CAS
13551-89-8
Created by admin on Mon Mar 31 22:32:08 GMT 2025 , Edited by admin on Mon Mar 31 22:32:08 GMT 2025
PRIMARY
PUBCHEM
92242
Created by admin on Mon Mar 31 22:32:08 GMT 2025 , Edited by admin on Mon Mar 31 22:32:08 GMT 2025
PRIMARY
FDA UNII
082285VIDF
Created by admin on Mon Mar 31 22:32:08 GMT 2025 , Edited by admin on Mon Mar 31 22:32:08 GMT 2025
PRIMARY