TROCLOSENE SODIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C3Cl2N3O3.Na
Molecular Weight	219.946
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].ClN1C(=O)[N-]C(=O)N(Cl)C1=O

InChI

InChIKey=MSFGZHUJTJBYFA-UHFFFAOYSA-M

InChI=1S/C3HCl2N3O3.Na/c4-7-1(9)6-2(10)8(5)3(7)11;/h(H,6,9,10);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	C3HCl2N3O3
Molecular Weight	197.964
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.fao.org/fileadmin/templates/agns/pdf/jecfa/cta/61/NaDCC.pdf
Curator's Comment: description was created based on several sources, including: http://www.preciseformulation.com/nadcc-tablets-general-applications.html | http://akvopedia.org/wiki/Chlorine_(NaDCC) | https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b345ae6a-0b36-45c7-b31e-2a15508a2ef5 | https://www.ncbi.nlm.nih.gov/pubmed/20064989

Troclosene is chlorinated hydroxytriazine and it is used as a source of free available chlorine, in the form of hypochlorous acid, for the disinfection of water. It kills bacteria, bacterial spores, cysts, algae, fungi, protozoa and virus and are especially lethal to Entamoeba histolytica. Troclosene kills mastitis-causing organisms. It is now widely available for household water treatment. It does not prevent diarrhea but improved water quality.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Diarrhea 35 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20064989 https://www.ncbi.nlm.nih.gov/pubmed/23976883	Preventing		Phase III 656	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
The efficacy of chemical agents in cleaning and disinfection programs.	2001	11591223
Bactericidal and cytotoxic effects of sodium hypochlorite and sodium dichloroisocyanurate solutions in vitro.	2001 Apr	11485267
Germicidal activities of representatives of five different teat dip classes against three bovine mycoplasma species using a modified excised teat model.	2002 Aug	12214982
Flow injection chemiluminescence determination of hydrazine by oxidation with chlorinated isocyanurates.	2002 Oct 16	18968808
Determination of ammonia in beers by pervaporation flow injection analysis and spectrophotometric detection.	2003 Aug 29	18969154
Flow-injection chemiluminescence determination of chlorinated isocyanuric acids.	2003 Feb	12589508
Determination of decimal reduction time (D value) of chemical agents used in hospitals for disinfection purposes.	2003 Oct 17	14563217
[Bioactive effectiveness of selected disinfective agents on Gram-negative bacilli isolated from hospital environment].	2004	15810507
Resistance of spheroplasts and whole cells of Pseudomonas aeruginosa to bactericidal activity of various biocides: evidence of the membrane implication.	2004	15160607
The effect of a range of disinfectants on the dimensional accuracy of some impression materials.	2004 Dec	15691188
Efficacy of three surface disinfectants for dental radiographic films and gloves.	2004 Jul	15193787
The effect of Perasafe and sodium dichloroisocyanurate (NaDCC) against spores of Clostridium difficile and Bacillus atrophaeus on stainless steel and polyvinyl chloride surfaces.	2004 Jun	15183245
Flow-injection determination of isoniazid using sodium dichloroisocyanurate- and trichloroisocyanuric acid-luminol chemiluminescence systems.	2004 Jun	15178311
Soft tissue dissolution capacity of currently used and potential endodontic irrigants.	2004 Nov	15505511
The effect of sterilization methods on the light transmission characteristics and structure of light-curing tips.	2004 Sep	15369476
Chlorine covers on living bacteria: the initial step in antimicrobial action of active chlorine compounds.	2005 Apr	15761074
Flow-injection potentiometric determination of triiodide by plasticized poly(vinyl chloride) membrane electrodes and its application to the determination of chlorine-containing disinfectants.	2005 Mar 15	18969930
[Study on the resistance of Escherichia coli O157:H7 to disinfectants in relationship with its plasmid pO157 and chromosome DNA].	2005 Nov	16334573
[Comparison on resistance of bacteriophages to sodium dichloroisocyanurate in laboratory].	2006 Jan	16620594
Sodium dichloroisocyanurate (NaDCC) tablets as an alternative to sodium hypochlorite for the routine treatment of drinking water at the household level.	2006 Mar	16387550
Whole-genome analysis of the SHORT-ROOT developmental pathway in Arabidopsis.	2006 May	16640459
Efficacy of hospital cleaning agents and germicides against epidemic Clostridium difficile strains.	2007 Aug	17620238
Household water treatment using sodium dichloroisocyanurate (NaDCC) tablets: a randomized, controlled trial to assess microbiological effectiveness in Bangladesh.	2007 Jan	17255252
Comparative sporicidal effects of disinfectants after release of a biological agent.	2007 Jun	17615843
Analytical method for the quantitative determination of cyanuric acid as the degradation product of sodium dichloroisocyanurate in urine by liquid chromatography mass spectrometry.	2007 Jun 15	17409034
Virucidal agents in the eve of manorapid synergy.	2007 Sep 13	20200679
Tonometer disinfection practice in the United Kingdom: a national survey.	2008 Aug	17464301
Sporicidal activity of two disinfectants against Clostridium difficile spores.	2008 Mar 13-26	18414294
Advantages of sodium hypochlorite or sodium dichloroisocyanurate disinfection for teats and bottles in newborn infants' feeding.	2008 Mar-Apr	18294178
UV-visible marker confirms that environmental persistence of Clostridium difficile spores in toilets of patients with C. difficile-associated diarrhea is associated with lack of compliance with cleaning protocol.e.	2008 May 12	18474086
Use of sodium dichloroisocyanurate for floor disinfection.	2009 Jul	19376611
Disinfection of irreversible hydrocolloid impression material with chlorinated compounds.	2009 Jun	19725332
Effects of pH and oil-in-water emulsions on growth and physicochemical cell surface properties of Listeria monocytogenes: Impact on tolerance to the bactericidal activity of disinfectants.	2009 Mar 31	19203811
A comparative study assaying commonly used sanitizers for antimicrobial activity against indicator bacteria and a Salmonella Typhimurium strain on fresh produce.	2009 Nov	19903410
[Specific antisepsis and environmental disinfection in preventing "Clostridium difficile associated diarrhea"].	2009 Nov-Dec	20169831
Collection of indonaphthol blue on a membrane filter for the spectrophotometric determination of ammonia with 1-naphthol and dichloroisocyanurate.	2010	20631439
Disinfection efficacy of sodium dichloroisocyanurate (NADCC) against common food-borne intestinal protozoa.	2010 Apr	20503596
Improvements to water purification and sanitation infrastructure may reduce the diarrheal burden in a marginalized and flood prone population in remote Nicaragua.	2010 Dec 8	21143865
Consumer exposure to biocides--identification of relevant sources and evaluation of possible health effects.	2010 Feb 3	20128903
Sodium dichloroisocyanurate tablets for routine treatment of household drinking water in periurban Ghana: a randomized controlled trial.	2010 Jan	20064989
Disinfection by-product formation and mitigation strategies in point-of-use chlorination with sodium dichloroisocyanurate in Tanzania.	2010 Jul	20595492
Jasmonic acid and ethylene modulate local responses to wounding and simulated herbivory in Nicotiana attenuata leaves.	2010 Jun	20382894
Root canal irrigants.	2010 Oct	21217955
Field assessment of a novel household-based water filtration device: a randomised, placebo-controlled trial in the Democratic Republic of Congo.	2010 Sep 10	20856584
1,1'-Azobis-1,2,3-triazole: a high-nitrogen compound with stable N8 structure and photochromism.	2010 Sep 8	20715773

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Viral suspensions were prepared containing 10(4)-10(5) syncitial forming units ml-1 in 0.9% saline or 0.9% saline containing 10% v/v plasma to simulate clean and dirty conditions. A syncitial inhibition assay on C8166 lymphoblastoid line was used to determine viral titre. Results indicate that satisfactory disinfection (3-4 log reduction in 2 min) can be achieved using Troclosene and NaOCl at concentrations of 50 ppm and 2500 ppm available chlorine (AvCl2) for clean and soiled conditions respectively. For treatment of blood spillages, the addition of Troclosene and NaOCl solutions (10,000 ppm) to equal volumes of contaminated blood (giving a final AvCl2 concentration of 5000 ppm of blood) was sufficient to produce total kill within 2 min.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:12:09 GMT 2023` Edited by `admin` on `Fri Dec 15 19:12:09 GMT 2023`
Record UNII	07M9U9U0LK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TROCLOSENE SODIUM

Common Name

English

TROCLOSENE SODIUM [HSDB]

Common Name

English

SODIUM TROCLOSENE

Common Name

English

SODIUM DICHLORO-S-TRIAZINETRIONE

Systematic Name

English

SODIUM DICHLOROCYANURATE

Common Name

English

TROCLOSENE SODIUM [MART.]

Common Name

English

SODIUM DICHLOROISOCYANURATE

Common Name

English

NADCC

Common Name

English

DICHLOROSAN

Common Name

English

1,3,5-TRIAZINE-2,4,6(1H,3H,5H)-TRIONE, 1,3-DICHLORO-, SODIUM SALT (1:1)

Common Name

English

ACTISEPT

Brand Name

English

SODIUM DICHLOROISOCYANURATE [JAN]

Common Name

English

DICHLOROISOCYANURIC ACID SODIUM SALT

Common Name

English

CLEARON

Brand Name

English

NEOCHLOR 55

Brand Name

English

Troclosene sodium [WHO-DD]

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

81404