5-HYDROXY-3,6,7,8,3',4'-HEXAMETHOXYFLAVONE

COC1=C(OC)C=C(C=C1)C2=C(OC)C(=O)C3=C(O2)C(OC)=C(OC)C(OC)=C3O

InChIKey=JDVPHCLYMGBZLE-UHFFFAOYSA-N

InChI=1S/C21H22O9/c1-24-11-8-7-10(9-12(11)25-2)16-18(26-3)14(22)13-15(23)19(27-4)21(29-6)20(28-5)17(13)30-16/h7-9,23H,1-6H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

PubMed

Title	Date	PubMed
Polymethoxylated flavones induce Ca(2+)-mediated apoptosis in breast cancer cells.	2006 Dec 23	17046027
Inhibitory effect of citrus 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mice.	2007 Dec	17962218
5-Hydroxy-3,6,7,8,3',4'-hexamethoxyflavone induces apoptosis through reactive oxygen species production, growth arrest and DNA damage-inducible gene 153 expression, and caspase activation in human leukemia cells.	2007 Jun 27	17536822
Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis.	2009 Mar	19065586
Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells.	2010 Jul	20397199
5-Hydroxy-3,6,7,8,3'4'-hexamethoxyflavone inhibits nitric oxide production in lipopolysaccharide-stimulated BV2 microglia via NF-κB suppression and Nrf-2-dependent heme oxygenase-1 induction.	2013 Jul	23542513

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:00:44 UTC 2023` Edited by `admin` on `Sat Dec 16 11:00:44 UTC 2023`
Record UNII	07JTS22V9J
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

5-HYDROXY-3,6,7,8,3',4'-HEXAMETHOXYFLAVONE

Systematic Name

English

FLAVONE, 5-HYDROXY-3,3',4',6,7,8-HEXAMETHOXY-

Systematic Name

English

4H-1-BENZOPYRAN-4-ONE, 2-(3,4-DIMETHOXYPHENYL)-5-HYDROXY-3,6,7,8-TETRAMETHOXY-

Systematic Name

English

NSC-618935

Code

English

Code System Code Type Description

NSC

618935