Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C21H22O9 |
| Molecular Weight | 418.394 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C(OC)C=C(C=C1)C2=C(OC)C(=O)C3=C(O)C(OC)=C(OC)C(OC)=C3O2
InChI
InChIKey=JDVPHCLYMGBZLE-UHFFFAOYSA-N
InChI=1S/C21H22O9/c1-24-11-8-7-10(9-12(11)25-2)16-18(26-3)14(22)13-15(23)19(27-4)21(29-6)20(28-5)17(13)30-16/h7-9,23H,1-6H3
| Molecular Formula | C21H22O9 |
| Molecular Weight | 418.394 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| 5-Hydroxy-3,6,7,8,3'4'-hexamethoxyflavone inhibits nitric oxide production in lipopolysaccharide-stimulated BV2 microglia via NF-κB suppression and Nrf-2-dependent heme oxygenase-1 induction. | 2013-07 |
|
| Quantitative analysis of hydroxylated polymethoxyflavones by high-performance liquid chromatography. | 2010-08 |
|
| Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells. | 2010-07 |
|
| Simultaneous determination of four 5-hydroxy polymethoxyflavones by reversed-phase high performance liquid chromatography with electrochemical detection. | 2010-01-29 |
|
| Polymethoxyflavones activate Ca2+-dependent apoptotic targets in adipocytes. | 2009-07-08 |
|
| Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis. | 2009-03 |
|
| Inhibitory effect of citrus 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mice. | 2007-12 |
|
| 5-Hydroxy-3,6,7,8,3',4'-hexamethoxyflavone induces apoptosis through reactive oxygen species production, growth arrest and DNA damage-inducible gene 153 expression, and caspase activation in human leukemia cells. | 2007-06-27 |
|
| Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines. | 2007-05-15 |
|
| Polymethoxylated flavones induce Ca(2+)-mediated apoptosis in breast cancer cells. | 2006-12-23 |
|
| Genetic toxicity of a standardized mixture of citrus polymethoxylated flavones. | 2002-05 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:34:23 GMT 2025
by
admin
on
Mon Mar 31 23:34:23 GMT 2025
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| Record UNII |
07JTS22V9J
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| Record Status |
Validated (UNII)
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| Record Version |
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07JTS22V9J
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136417
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DTXSID50151834
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> CONSTITUENT ALWAYS PRESENT |
35% Cell growth rate of mouse myeloid leukemia M1 cells at 50 uM of compound vs control
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PARENT -> CONSTITUENT ALWAYS PRESENT |
56% Cell growth rate of human acute promyelocytic leukemia HL-60 cells at 50 uM of compound vs control
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