THIOACETAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H5NS
Molecular Weight	75.133
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(N)=S

InChI

InChIKey=YUKQRDCYNOVPGJ-UHFFFAOYSA-N

InChI=1S/C2H5NS/c1-2(3)4/h1H3,(H2,3,4)

HIDE SMILES / InChI

Molecular Formula	C2H5NS
Molecular Weight	75.133
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
[Synthesis, preliminary antigastrelcosis activity and the protective effect on acute liver injury of zinc chlorin E4].	2001 Mar	12580085
Level of superoxide dismutase, glutathione peroxidase and uric acid in thioacetamide-induced cirrhotic rats.	2002 Apr	12047241
Thioacetamide impairs retinol storage and dolichol content in rat liver cells in vivo.	2002 Aug 8	12176393
Effects of ammonia and hepatic failure on the net efflux of endogenous glutamate, aspartate and taurine from rat cerebrocortical slices: modulation by elevated K+ concentrations.	2002 Aug-Sep	12020608
Usefulness of the tactile sensor for estimating the degree of liver fibrosis and the DNA synthesis activity of remnant liver cells after partial hepatectomy.	2002 Dec	12680613
Liver protection from apoptosis requires both blockage of initiator caspase activities and inhibition of ASK1/JNK pathway via glutathione S-transferase regulation.	2002 Dec 20	12370186
Aminoguanidine, an inducible nitric oxide synthase inhibitor, plus N-acetylcysteine treatment reduce the lipopolysaccharide-augmented hepatotoxicity in rats with cirrhosis.	2002 Jul	12269697
Dolichol content in isolated sinusoidal liver cells after in vivo chronic treatment with thioacetamide.	2002 Jul	12180801
Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver.	2002 Jul	12085344
Alterations to hepatic microcirculation in thioacetamide-induced cirrhotic livers of rats.	2002 Jun	12375692
[Experimental portal hypertensive colopathy in rats with liver cirrhosis].	2002 Jun	12099003
Changes in serum hyaluronic acid levels and expression of CD44 and CD44 mRNA in hepatic sinusoidal endothelial cells after major hepatectomy in cirrhotic rats.	2002 Jun	12053221
Influence of aging on the carcinogen-induced protein kinase activity in rat liver cell nuclei.	2002 Mar	12002269
Hepatotoxicity and aging: endogenous antioxidant systems in hepatocytes from 2-, 6-, 12-, 18- and 30-month-old rats following a necrogenic dose of thioacetamide.	2002 May 21	12009419
Hemodynamics in the microvasculature of thioacetamide-induced cirrhotic rat livers.	2002 May-Jun	12063962
Alpha-glutathione S-transferase in the assessment of hepatotoxicity--its diagnostic utility in comparison with other recognized markers in the Wistar Han rat.	2002 May-Jun	12051554
Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fischer 344 male rats.	2002 Nov	12470904
Changes in expression of cell cycle regulators after G1 progression upon repetitive thioacetamide treatment in rat liver.	2002 Nov 30	12526100
Hepatic stimulator substance activity in animal model of fulminant hepatic failure and encephalopathy.	2002 Oct	12395888
Upregulated promitogenic signaling via cytokines and growth factors: potential mechanism of robust liver tissue repair in calorie-restricted rats upon toxic challenge.	2002 Oct	12377994
Immunohistochemical studies on the expression pattern of molecular chaperones HSC70 and HSP25 and cell cycle-related proteins cyclin D1 and PCNA in rat liver after thioacetamide intoxication.	2002 Oct	12376827
Halofuginone, a collagen type I inhibitor improves liver regeneration in cirrhotic rats.	2002 Sep	12175628
Tolerance to intermittent ischemia of damaged rat liver by thioacetamide.	2002 Sep-Oct	12239937
Tetramethylpyrazine protects mice against thioacetamide-induced acute hepatotoxicity.	2002 Sep-Oct	12218355
Following the formation of nanometer-sized clusters by time-resolved SAXS and EXAFS techniques.	2003	12555858
Expression of growth hormone receptor and its mRNA in hepatic cirrhosis.	2003 Apr	12679928
Mechanisms of increased liver tissue repair and survival in diet-restricted rats treated with equitoxic doses of thioacetamide.	2003 Apr	12655029
Streptozotocin-induced diabetic mice are resistant to lethal effects of thioacetamide hepatotoxicity.	2003 Apr 15	12691730
Gliotoxin ameliorates development of fibrosis and cirrhosis in a thioacetamide rat model.	2003 Aug	12924662
JTE-522, a cyclooxygenase-2 inhibitor, is an effective chemopreventive agent against rat experimental liver fibrosis1.	2003 Aug	12891558
Evaluation of the developmental toxicities of ethanol, acetaldehyde, and thioacetamide using FETAX.	2003 Feb	12643038
Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat.	2003 Feb	12557150
Emergence of different macrophage populations in hepatic fibrosis following thioacetamide-induced acute hepatocyte injury in rats.	2003 Jan	12531686
Role of metabolism by flavin-containing monooxygenase in thioacetamide-induced immunosuppression.	2003 Jan 13	12505269
A single administration of adenoviral-mediated HGF cDNA permits survival of mice from acute hepatic failure.	2003 Jan 3	12479984
Hepatic 31P MRS in rat models of chronic liver disease: assessing the extent and progression of disease.	2003 Jul	12801965
Hepatic stimulator substance administration ameliorates liver regeneration in an animal model of fulminant hepatic failure and encephalopathy.	2003 Jun	12955880
Differentially expressed genes in the liver of thioacetamide treated rats.	2003 Jun	12860051
A trial on regeneration therapy of rat liver cirrhosis by controlled release of hepatocyte growth factor.	2003 Mar 7	12628327
Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fisher 344 male rats [Mechanisms of Ageing and Development 123 (2002) 1665-1680].	2003 May	12825548
Zinc supplementation attenuates thioacetamide-induced liver injury and hyperglycemia in mice.	2003 May	12746576
Overexpression of thioredoxin prevents acute hepatitis caused by thioacetamide or lipopolysaccharide in mice.	2003 May	12717382
The effects of early and late administration of inhibitors of inducible nitric oxide synthase in a thioacetamide-induced model of acute hepatic failure in the rat.	2003 May	12713868
Impact of endothelin-1 on microcirculatory disturbance after partial hepatectomy under ischemia/reperfusion in thioacetamide-induced cirrhotic rats.	2003 May 1	12842454
Hepatocyte ploidy in regenerating livers after partial hepatectomy, drug-induced necrosis, and cirrhosis.	2003 May-Jun	12740535
Sonochemical fabrication and characterization of stibnite nanorods.	2003 Oct 6	14514316
Granulocyte-colony stimulating factor administration ameliorates liver regeneration in animal model of fulminant hepatic failure and encephalopathy.	2003 Sep	14561004
Lethal hepatic injury by combined treatment of radiation plus chemotherapy in rats with thioacetamide-induced liver cirrhosis.	2003 Sep 1	12909244
Depletion of Kupffer cell function by gadolinium chloride attenuates thioacetamide-induced hepatotoxicity. Expression of metallothionein and HSP70.	2003 Sep 15	12963478
Hepatotoxin-induced hypercreatinaemia and hypercreatinuria: their relationship to one another, to liver damage and to weakened nutritional status.	2004 Feb	14520508

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:50:23 UTC 2023` Edited by `admin` on `Fri Dec 15 17:50:23 UTC 2023`
Record UNII	075T165X8M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

THIOACETAMIDE

Systematic Name

English

THIOACETAMIDE [IARC]

Common Name

English

NSC-2120

Code

English

THIOACETAMIDE [MI]

Common Name

English

THIOACETAMIDE [HSDB]

Common Name

English

ACETOTHIOAMIDE

Systematic Name

English

ETHANETHIOAMIDE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C45175