THIOACETAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H5NS
Molecular Weight	75.133
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(N)=S

InChI

InChIKey=YUKQRDCYNOVPGJ-UHFFFAOYSA-N

InChI=1S/C2H5NS/c1-2(3)4/h1H3,(H2,3,4)

HIDE SMILES / InChI

Molecular Formula	C2H5NS
Molecular Weight	75.133
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Hepatotoxin-induced hypercreatinaemia and hypercreatinuria: their relationship to one another, to liver damage and to weakened nutritional status.	2004-02	14520508
Sonochemical fabrication and characterization of stibnite nanorods.	2003-10-06	14514316
Depletion of Kupffer cell function by gadolinium chloride attenuates thioacetamide-induced hepatotoxicity. Expression of metallothionein and HSP70.	2003-09-15	12963478
Lethal hepatic injury by combined treatment of radiation plus chemotherapy in rats with thioacetamide-induced liver cirrhosis.	2003-09-01	12909244
Granulocyte-colony stimulating factor administration ameliorates liver regeneration in animal model of fulminant hepatic failure and encephalopathy.	2003-09	14561004
Gliotoxin ameliorates development of fibrosis and cirrhosis in a thioacetamide rat model.	2003-08	12924662
JTE-522, a cyclooxygenase-2 inhibitor, is an effective chemopreventive agent against rat experimental liver fibrosis1.	2003-08	12891558
Hepatic 31P MRS in rat models of chronic liver disease: assessing the extent and progression of disease.	2003-07	12801965
Hepatic stimulator substance administration ameliorates liver regeneration in an animal model of fulminant hepatic failure and encephalopathy.	2003-06	12955880
Differentially expressed genes in the liver of thioacetamide treated rats.	2003-06	12860051
Impact of endothelin-1 on microcirculatory disturbance after partial hepatectomy under ischemia/reperfusion in thioacetamide-induced cirrhotic rats.	2003-05-01	12842454
Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fisher 344 male rats [Mechanisms of Ageing and Development 123 (2002) 1665-1680].	2003-05	12825548
Zinc supplementation attenuates thioacetamide-induced liver injury and hyperglycemia in mice.	2003-05	12746576
Overexpression of thioredoxin prevents acute hepatitis caused by thioacetamide or lipopolysaccharide in mice.	2003-05	12717382
The effects of early and late administration of inhibitors of inducible nitric oxide synthase in a thioacetamide-induced model of acute hepatic failure in the rat.	2003-05	12713868
Streptozotocin-induced diabetic mice are resistant to lethal effects of thioacetamide hepatotoxicity.	2003-04-15	12691730
Expression of growth hormone receptor and its mRNA in hepatic cirrhosis.	2003-04	12679928
Mechanisms of increased liver tissue repair and survival in diet-restricted rats treated with equitoxic doses of thioacetamide.	2003-04	12655029
A trial on regeneration therapy of rat liver cirrhosis by controlled release of hepatocyte growth factor.	2003-03-07	12628327
Evaluation of the developmental toxicities of ethanol, acetaldehyde, and thioacetamide using FETAX.	2003-02	12643038
Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat.	2003-02	12557150
Role of metabolism by flavin-containing monooxygenase in thioacetamide-induced immunosuppression.	2003-01-13	12505269
A single administration of adenoviral-mediated HGF cDNA permits survival of mice from acute hepatic failure.	2003-01-03	12479984
Emergence of different macrophage populations in hepatic fibrosis following thioacetamide-induced acute hepatocyte injury in rats.	2003-01	12531686
Following the formation of nanometer-sized clusters by time-resolved SAXS and EXAFS techniques.	2003	12555858
Liver protection from apoptosis requires both blockage of initiator caspase activities and inhibition of ASK1/JNK pathway via glutathione S-transferase regulation.	2002-12-20	12370186
Usefulness of the tactile sensor for estimating the degree of liver fibrosis and the DNA synthesis activity of remnant liver cells after partial hepatectomy.	2002-12	12680613
Changes in expression of cell cycle regulators after G1 progression upon repetitive thioacetamide treatment in rat liver.	2002-11-30	12526100
Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fischer 344 male rats.	2002-11	12470904
Hepatic stimulator substance activity in animal model of fulminant hepatic failure and encephalopathy.	2002-10	12395888
Upregulated promitogenic signaling via cytokines and growth factors: potential mechanism of robust liver tissue repair in calorie-restricted rats upon toxic challenge.	2002-10	12377994
Immunohistochemical studies on the expression pattern of molecular chaperones HSC70 and HSP25 and cell cycle-related proteins cyclin D1 and PCNA in rat liver after thioacetamide intoxication.	2002-10	12376827
Tolerance to intermittent ischemia of damaged rat liver by thioacetamide.	2002-09-21	12239937
Tetramethylpyrazine protects mice against thioacetamide-induced acute hepatotoxicity.	2002-09-10	12218355
Halofuginone, a collagen type I inhibitor improves liver regeneration in cirrhotic rats.	2002-09	12175628
Hepatocyte ploidy in regenerating livers after partial hepatectomy, drug-induced necrosis, and cirrhosis.	2002-08-13	12740535
Thioacetamide impairs retinol storage and dolichol content in rat liver cells in vivo.	2002-08-08	12176393
Aminoguanidine, an inducible nitric oxide synthase inhibitor, plus N-acetylcysteine treatment reduce the lipopolysaccharide-augmented hepatotoxicity in rats with cirrhosis.	2002-07	12269697
Dolichol content in isolated sinusoidal liver cells after in vivo chronic treatment with thioacetamide.	2002-07	12180801
Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver.	2002-07	12085344
Hemodynamics in the microvasculature of thioacetamide-induced cirrhotic rat livers.	2002-06-18	12063962
Alpha-glutathione S-transferase in the assessment of hepatotoxicity--its diagnostic utility in comparison with other recognized markers in the Wistar Han rat.	2002-06-08	12051554
Alterations to hepatic microcirculation in thioacetamide-induced cirrhotic livers of rats.	2002-06	12375692
[Experimental portal hypertensive colopathy in rats with liver cirrhosis].	2002-06	12099003
Changes in serum hyaluronic acid levels and expression of CD44 and CD44 mRNA in hepatic sinusoidal endothelial cells after major hepatectomy in cirrhotic rats.	2002-06	12053221
Effects of ammonia and hepatic failure on the net efflux of endogenous glutamate, aspartate and taurine from rat cerebrocortical slices: modulation by elevated K+ concentrations.	2002-05-22	12020608
Hepatotoxicity and aging: endogenous antioxidant systems in hepatocytes from 2-, 6-, 12-, 18- and 30-month-old rats following a necrogenic dose of thioacetamide.	2002-05-21	12009419
Level of superoxide dismutase, glutathione peroxidase and uric acid in thioacetamide-induced cirrhotic rats.	2002-04	12047241
Influence of aging on the carcinogen-induced protein kinase activity in rat liver cell nuclei.	2002-03	12002269
[Synthesis, preliminary antigastrelcosis activity and the protective effect on acute liver injury of zinc chlorin E4].	2001-03	12580085

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:54:41 GMT 2025` Edited by `admin` on `Mon Mar 31 18:54:41 GMT 2025`
Record UNII	075T165X8M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NSC-2120

Preferred Name

English

THIOACETAMIDE

Systematic Name

English

THIOACETAMIDE [IARC]

Common Name

English

THIOACETAMIDE [MI]

Common Name

English

THIOACETAMIDE [HSDB]

Common Name

English

ACETOTHIOAMIDE

Systematic Name

English

ETHANETHIOAMIDE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C45175