INDOLICIDIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C100H132N26O13
Molecular Weight	1906.2845
Optical Activity	UNSPECIFIED
Defined Stereocenters	14 / 14
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC2=CNC3=C2C=CC=C3)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC4=CNC5=C4C=CC=C5)C(=O)N6CCC[C@H]6C(=O)N[C@H](CC7=CNC8=C7C=CC=C8)C(=O)N[C@@H](CC9=CNC%10=C9C=CC=C%10)C(=O)N%11CCC[C@H]%11C(=O)N[C@@H](CC%12=CNC%13=C%12C=CC=C%13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

InChI

InChIKey=USSYUMHVHQSYNA-PYODXXEMSA-N

InChI=1S/C100H132N26O13/c1-5-57(4)85(102)95(136)123-79(45-56(2)3)96(137)124-42-20-36-82(124)92(133)118-76(46-58-51-110-68-28-11-6-23-63(58)68)89(130)116-74(33-16-17-39-101)88(129)121-80(49-61-54-113-71-31-14-9-26-66(61)71)97(138)125-43-21-38-84(125)94(135)120-78(48-60-53-112-70-30-13-8-25-65(60)70)91(132)122-81(50-62-55-114-72-32-15-10-27-67(62)72)98(139)126-44-22-37-83(126)93(134)119-77(47-59-52-111-69-29-12-7-24-64(59)69)90(131)117-75(35-19-41-109-100(106)107)87(128)115-73(86(103)127)34-18-40-108-99(104)105/h6-15,23-32,51-57,73-85,110-114H,5,16-22,33-50,101-102H2,1-4H3,(H2,103,127)(H,115,128)(H,116,130)(H,117,131)(H,118,133)(H,119,134)(H,120,135)(H,121,129)(H,122,132)(H,123,136)(H4,104,105,108)(H4,106,107,109)/t57-,73-,74-,75-,76-,77-,78+,79-,80-,81-,82-,83-,84-,85-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C100H132N26O13
Molecular Weight	1906.2845
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	14 / 14
E/Z Centers	2
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
High potency and broad-spectrum antimicrobial peptides synthesized via ring-opening polymerization of alpha-aminoacid-N-carboxyanhydrides.	2010-01-11	19957992
Fungicidal activity of five cathelicidin peptides against clinically isolated yeasts.	2006-11	17023499
Synthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin.	2004-11-15	15482931
Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus.	2004-04	15081088
Cathelicidin peptides as candidates for a novel class of antimicrobials.	2002	11945171
Activity of nitazoxanide alone and in combination with azithromycin and rifabutin against Cryptosporidium parvum in cell culture.	2000-04	10747821
Structural features and biological activities of the cathelicidin-derived antimicrobial peptides.	2000	10931440
In vitro anticryptosporidial activity of ranalexin alone and in combination with other peptides and with hydrophobic antibiotics.	1999-11	10614961
Antimicrobial activity of polycationic peptides.	1999-11	10612440
In-vitro activity of polycationic peptides against Cryptosporidium parvum, Pneumocystis carinii and yeast clinical isolates.	1999-09	10511411
In-vitro activity of lytic peptides alone and in combination with macrolides and inhibitors of dihydrofolate reductase against Pneumocystis carinii.	1998-10	9818742
Anti-HIV-1 activity of indolicidin, an antimicrobial peptide from neutrophils.	1998-01	9469478
Liposomal entrapment of the neutrophil-derived peptide indolicidin endows it with in vivo antifungal activity.	1995-07-26	7632702

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:46:10 GMT 2025` Edited by `admin` on `Mon Mar 31 22:46:10 GMT 2025`
Record UNII	073SBV429N
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

INDOLICIDIN

Common Name

English

H-ILE-LEU-PRO-TRP-LYS-TRP-PRO-TRP-TRP-PRO-TRP-ARG-ARG-NH2

Preferred Name

English

L-ARGININAMIDE, L-ISOLEUCYL-L-LEUCYL-L-PROLYL-L-TRYPTOPHYL-L-LYSYL-L-TRYPTOPHYL-L-PROLYL-L-TRYPTOPHYL-L-TRYPTOPHYL-L-PROLYL-L-TRYPTOPHYL-L-ARGINYL-

Systematic Name

English

INDOLICIDIN [MI]

Common Name

English

Code System Code Type Description

PUBCHEM

90478486