MIBOPLATIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C6H6O4.C5H12N2.Pt
Molecular Weight	437.356
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Pt++].[H][C@]1(CN)CCCN1.[O-]C(=O)C2(CCC2)C([O-])=O

InChI

InChIKey=XXUHLUDUCZQMDI-UTYJZAQGSA-L

InChI=1S/C6H8O4.C5H12N2.Pt/c7-4(8)6(5(9)10)2-1-3-6;6-4-5-2-1-3-7-5;/h1-3H2,(H,7,8)(H,9,10);5,7H,1-4,6H2;/q;;+2/p-2/t;5-;/m.1./s1

HIDE SMILES / InChI

Molecular Formula	Pt
Molecular Weight	195.084
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C5H12N2
Molecular Weight	100.1622
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	C6H6O4
Molecular Weight	142.1094
Charge	-2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: Sigel Astrid, Sigel Helmut , Freisinger Eva , Sigel Roland K.O., Metallo-Drugs: Development and Action of Anticancer Agents, retrieved from: https://books.google.ru/books?id=sMtNDwAAQBAJ&pg=PA24&lpg=PA24&dq=MIBOPLATIN&source=bl&ots=NXh7SQySMf&sig=ACfU3U1Vc2_Urs579EYbcG7w_iFQF-qWig&hl=ru&sa=X&ved=2ahUKEwj7rpf72tXiAhUBi8MKHQaeC0o4FBDoATAGegQICRAB#v=onepage&q=MIBOPLATIN&f=false | https://adisinsight.springer.com/drugs/800000844

Miboplatin (DWA 2114R) is a platinum analog developed for the treatment of cancer. Miboplatin is an alkylating agent that reached phase III clinical trials in Japan. In spite of its good anticancer activity, the drug did not show any advantage over cisplatin. Further development of this drug for the treatment of breast, ovarian and prostate cancer was discontinued.

Originator

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:07:08 GMT 2023` Edited by `admin` on `Fri Dec 15 19:07:08 GMT 2023`
Record UNII	06241B5S4P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MIBOPLATIN

Official Name

English

MIBOPLATIN HYDRATE [JAN]

Common Name

English

miboplatin [INN]

Common Name

English

(-)-CIS-((R)-2-(AMINOMETHYL)PYRROLIDINE)(1,1-CYCLOBUTANEDICARBOXYLATO)PLATINUM

Common Name

English

MIBOPLATIN [MART.]

Common Name

English

MIBOPLATIN [MI]

Common Name

English

Code System Code Type Description

INN

6848