METHITURAL SODIUM

US Previously Marketed

First approved in 1956

Details

Stereochemistry	RACEMIC
Molecular Formula	C12H19N2O2S2.Na
Molecular Weight	310.411
Optical Activity	( + / - )
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].CCCC(C)C1(CCSC)C(=O)NC(=S)[N-]C1=O

InChI

InChIKey=IPFUISOJBWATGQ-UHFFFAOYSA-M

InChI=1S/C12H20N2O2S2.Na/c1-4-5-8(2)12(6-7-18-3)9(15)13-11(17)14-10(12)16;/h8H,4-7H2,1-3H3,(H2,13,14,15,16,17);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	C12H20N2O2S2
Molecular Weight	288.429
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19598750 | https://pubchem.ncbi.nlm.nih.gov/compound/3032307

METHITURAL (as sodium salt) is a barbiturate derivative which was used as an ultrashort-acting intravenous anesthetic.

CNS Activity

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
skeletal muscle relaxation 7 Sources: https://link.springer.com/article/10.1007/BF03015276	Primary		Approved 8583	Neraval Approved Use Neraval is an ultra short-acting thiobarbiturate for intravenous administration. In doses of 10 cc. of a 5% solution it swiftly induces light anesthesia.

C_max

Value	Dose	Co-administered	Analyte	Population
35 mg/L EXPERIMENT https://www.karger.com/Article/PDF/134815	50 mg/kg bw single, intravenous dose: 50 mg/kg bw route of administration: Intravenous experiment type: SINGLE co-administered:		METHITURAL plasma	Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
	CYP 303

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
CYP 303	substrate 4014 Sources: https://onlinelibrary.wiley.com/doi/10.1002/9780470921920.edm145	yes

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1MHTWF
Alfa Chemistry	467-43-6	https://www.alfa-chemistry.com/cas_467-43-6.htm
Chemieliva Pharmaceutical Co., Ltd	PBCM1311781
ChemMol	99087657	http://www.chemmol.com/chemmol/99087657.html
Compound Cloud	3032307
NovoSeek	3032307
THE BioTek	bt-409956	https://www.thebiotek.com/product/others/bt-409956
ZINC	ZINC000001530824	http://zinc15.docking.org/substances/ZINC000001530824
ZINC	ZINC000001530825	http://zinc15.docking.org/substances/ZINC000001530825

PubMed

Title	Date	PubMed
Neraval, Evipal, Pentothal, Surital: A Clinical Evaluation.	1958-04	19598750
Neraval (methitural sodium) (sch. 3132).	1957-01	13396640
Methitural sodium (neraval sodium): a new ultrashort acting intravenous anesthetic.	1956-09-01	13355014
Methitural, a new intravenous anesthetic: comparison with thiopental in the cat, dog and monkey.	1956-03	13307393

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:46:41 GMT 2025` Edited by `admin` on `Mon Mar 31 21:46:41 GMT 2025`
Record UNII	054NQ722GD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

METHITURAL SODIUM SALT

Preferred Name

English

METHITURAL SODIUM

Common Name

English

NERAVAL

Brand Name

English

SCH-3132

Code

English

THIOGENAL

Brand Name

English

SODIUM METHIURAL

Common Name

English

METHIOTURIATE

Brand Name

English

4,6(1H,5H)-PYRIMIDINEDIONE, DIHYDRO-5-(1-METHYLBUTYL)-5-(2-(METHYLTHIO)ETHYL)-2-THIOXO-, SODIUM SALT (1:1)

Systematic Name

English

METHITURAL SODIUM SALT [MI]

Common Name

English

AM-109

Code

English

Code System Code Type Description

MERCK INDEX

m7320