NICODICODINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H26N2O4
Molecular Weight	406.4742
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12OC3=C(OC)C=CC4=C3[C@@]15CCN(C)[C@H](C4)[C@]5([H])CC[C@@H]2OC(=O)C6=CC=CN=C6

InChI

InChIKey=GTGRMWCOZHEYRL-MJFIPZRTSA-N

InChI=1S/C24H26N2O4/c1-26-11-9-24-16-6-8-19(29-23(27)15-4-3-10-25-13-15)22(24)30-21-18(28-2)7-5-14(20(21)24)12-17(16)26/h3-5,7,10,13,16-17,19,22H,6,8-9,11-12H2,1-2H3/t16-,17+,19-,22-,24-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C24H26N2O4
Molecular Weight	406.4742
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://books.google.ru/books?id=0vXTBwAAQBAJ&pg=PA865&lpg=PA865&dq=NICODICODINE retrieved from The Dictionary of Drugs: Chemical Data. Chemical Data, Structures and Bibliographies. Editors: Elks, J. (Ed.), p.865 | https://www.unodc.org/documents/commissions/CND/Int_Drug_Control_Conventions/1961_Schedules/ST-CND-1-Add1_E.pdf | https://books.google.ru/books?id=plWaCwAAQBAJ&pg=PA110&lpg=PA110&dq=Nicodicodeine&redir_esc=y&hl=en#v=onepage&q=Nicodicodeine&f=false retrieved from Painkillers: History, Science, and Issues By Victor B. Stolberg, p. 110

Nicodicodine is a cough suppressant and analgesic. It was first synthesized in 1904. It is a Schedule III drug. Nicodicodine is metabolised in the liver to dihydromorphine. Since the final active metabolite is the slightly stronger opiate than morphine, nicodicodine can be expected to be more potent and longer acting than nicocodeine.

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:40:58 GMT 2023` Edited by `admin` on `Fri Dec 15 15:40:58 GMT 2023`
Record UNII	04G0T06UGT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NICODICODINE

Official Name

English

IDS-NN-002(SECT.2)

Code

English

nicodicodine [INN]

Common Name

English

MORPHINAN-6-OL, 4,5-EPOXY-3-METHOXY-17-METHYL-, 9-(3-PYRIDINECARBOXYLATE), (5.ALPHA.,6.ALPHA.)-

Systematic Name

English

CODEINE, DIHYDRO-, NICOTINATE

Common Name

English

6-NICOTINOYL DIHYDROCODEINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66917