1,8-NAPHTHYRIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H6N2
Molecular Weight	130.1466
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C1=CC2=C(N=C1)N=CC=C2

InChI

InChIKey=FLBAYUMRQUHISI-UHFFFAOYSA-N

InChI=1S/C8H6N2/c1-3-7-4-2-6-10-8(7)9-5-1/h1-6H

HIDE SMILES / InChI

Molecular Formula	C8H6N2
Molecular Weight	130.1466
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Modeling the syn disposition of nitrogen donors at the active sites of carboxylate-bridged diiron enzymes. Enforcing dinuclearity and kinetic stability with a 1,2-diethynylbenzene-based ligand.	2003 Dec 29	14686842
Synthesis and beta-blocking activity of (R,S)-(E)-oximeethers of 2,3-dihydro-1,8-naphthyridine and 2,3-dihydrothiopyrano[2,3-b]pyridine: identification of beta 3-antagonists.	2003 Nov 17	14604653
Synthesis and biological evaluation of 1,8-naphthyridin-4(1H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptors.	2004 Apr 15	15051060
Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 2.	2004 Apr 8	15056007
Novel inhibitors of bacterial protein synthesis: structure-activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants.	2004 Jun 21	15149694
Synthesis and structure-activity relationships of 3-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridines as novel antitumor agents.	2004 Jun 21	15149673
Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives.	2004 Jun 3	15163184
Syntheses and EGFR kinase inhibitory activity of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles.	2004 Mar 22	15006373
Part 3: synthesis and biological evaluation of some analogs of the antitumor agents, 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid, and 2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic acid.	2005 Feb 15	15670915
Structure-phototoxicity relationship in Balb/c mice treated with fluoroquinolone derivatives, followed by ultraviolet-A irradiation.	2005 Jul 4	15917145
Tetrakis(mu(2)-1,8-naphthyridine)-1:2kappa(4)N:N';3:4kappa(4)N:N'-bis(mu(2)-salicylato)-1:4kappa(2)O:O';2:3kappa(2)O:O'-tetrakis(salicylic acid)-1kappaO,2kappaO,3kappaO,4kappaO-tetrasilver(I)(4 Ag-Ag).	2005 Jun	15930659
1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors.	2005 Oct 15	16099648
Synthesis and spectral investigations of manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) complexes of new polydentate ligands containing a 1,8-naphthyridine moiety.	2006 Dec 21	18007404
Effects of anti-inflammatory [1, 2, 4]triazolo[4, 3-a] [1, 8]naphthyridine derivatives on human stimulated PMN and endothelial cells: an in vitro study.	2006 Mar 28	16569220
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists.	2007 Dec 1	17942307
7-[4-(5,7-Dimethyl-1,8-naphthyridin-2-yl-oxy)phen-oxy]-2,4-dimethyl-1,8-naphthyridine methanol disolvate.	2007 Dec 12	21200814
7-Acetyl-amino-2,4-dimethyl-1,8-naphthyridine.	2007 Dec 6	21200676
Bis(7-amino-2,4-dimethyl-1,8-naphthyridine)dinitratocadmium(II).	2007 Dec 6	21200626
Dichloridobis(7-amino-2,4-dimethyl-1,8-naphthyridine-κN,N')cobalt(II) methanol disolvate.	2007 Dec 6	21200493
Oxacalixarenes and oxacyclophanes containing 1,8-naphthyridines: a new class of molecular tweezers with concave-surface functionality.	2007 Mar 14	17325794
Photochromism of photoenolizable ketones in quinoline and 1,8-naphthyridine series studied by time-resolved absorption spectroscopy.	2007 Mar 15	17388272
Synthesis and structure-activity relationships of potent antitumor active quinoline and naphthyridine derivatives.	2007 Nov	18045063
Effect of an alkyl amino group on the binding of 1,8-naphthyridines to AP site-containing DNA duplexes.	2008	18776281
One-pot solvent free synthesis and DNA binding studies of thieno[2,3-b]-1,8-naphthyridines.	2008	18080916
Naphthyridine-based helical foldamers and macrocycles: synthesis, cation binding, and supramolecular assemblies.	2008 Apr 4	18315005
2,2'-Dimethyl-7,7'-(methyl-enediimino)di-1,8-naphthyridin-1-ium bis-(perchlorate).	2008 Aug 6	21201691
cis,trans-Dicarbonyl-dichlorido[2-(2-pyrid-yl)-1,8-naphthyridine-κN,N]ruthenium(II).	2008 Feb 6	21201842
Quantitative structure-activity relationship study on affinity profile of a series of 1,8-naphthyridine antagonists toward bovine adenosine receptors.	2008 Jun	18569352
A 1,8-naphthyridine-based fluorescent chemodosimeter for the rapid detection of Zn2+ and Cu2+.	2008 Nov 20	18954057
Synthesis of binuclear platinum complexes containing the ligands 8-naphthyridine, 2-aminopyridine, and 7-azaindolate. An experimental study of the steric hindrance of the bulky pentafluorophenyl ligands in the synthesis of binuclear complexes.	2008 Oct 6	18767797
Synthesis and in-vitro antitumour activity of new naphthyridine derivatives on human pancreatic cancer cells.	2009 Aug	19703350
7-(2,2-Dimethylpropanamido)-2-methyl-1,8-naphthyridin-1-ium chloride monohydrate.	2009 Jan 17	21581941
Synthesis and cytotoxic activity of 5,6-heteroaromatically annulated pyridine-2,4-diamines.	2009 Jul 1	19481463
2,7-Dimethyl-1,8-naphthyridine.	2009 Jul 4	21583458
μ-Bis(5,7-dimethyl-1,8-naphthyridin-2-yl)diazene]bis-[difluoridoboron(III).	2009 Jun 24	21582932
2,2',4,4'-Tetra-methyl-7,7'-diazenediylbis(1,8-naphthyridin-1-ium) bis-(perchlorate).	2009 Jun 6	21582799
1-Ethyl-N'-[(E)-4-hydroxy-benzyl-idene]-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide.	2009 Mar 25	21582576
N'-[(E)-Benzyl-idene]-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide.	2009 Nov 21	21578871
Anticancer and immunomodulatory activities of novel 1,8-naphthyridine derivatives.	2009 Oct	19555167
CoMFA and CoMSIA analyses on 4-oxo-1,4-dihydroquinoline and 4-oxo-1,4-dihydro-1,5-, -1,6- and -1,8-naphthyridine derivatives as selective CB2 receptor agonists.	2010 Apr	19809837
Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II.	2010 Apr 15	20419121
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.	2010 Apr 22	20307063
Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.	2010 Aug 1	20615696
2,7-Bis-(trichloro-meth-yl)-1,8-naphthyridine.	2010 Feb 13	21580380
Intense one- and two-photon excited fluorescent bis(BF2) core complex containing a 1,8-naphthyridine derivative.	2010 Jul 2	20509633
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.	2010 Jul 22	20575555
2-Chloro-7-methyl-12-phenyldibenzo[b,g][1,8]naphthyridin-11(6H)-one.	2010 Jun 26	21588030
[Molecular geometries and theoretical electronic spectra of four 1,8-naphthyridine derivatives].	2010 Mar	20496665
Synthesis, characterization, photoinduced isomerization, and spectroscopic properties of vinyl-1,8-naphthyridine derivatives and their copper(I) complexes.	2010 May 17	20408579
Molecular modeling studies of 4,5-dihydro-1H-pyrazolo[4,3-h] quinazoline derivatives as potent CDK2/Cyclin a inhibitors using 3D-QSAR and docking.	2010 Sep 28	21152296

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:51:49 GMT 2023` Edited by `admin` on `Fri Dec 15 17:51:49 GMT 2023`
Record UNII	043R04VL4M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1,8-NAPHTHYRIDINE

Systematic Name

English

1,8-PYRIDOPYRIDINE

Common Name

English

1,8-DIAZANAPHTHALENE

Systematic Name

English

Code System Code Type Description

CHEBI

36628