1,8-NAPHTHYRIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H6N2
Molecular Weight	130.1466
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C1=CN=C2N=CC=CC2=C1

InChI

InChIKey=FLBAYUMRQUHISI-UHFFFAOYSA-N

InChI=1S/C8H6N2/c1-3-7-4-2-6-10-8(7)9-5-1/h1-6H

HIDE SMILES / InChI

Molecular Formula	C8H6N2
Molecular Weight	130.1466
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Molecular modeling studies of 4,5-dihydro-1H-pyrazolo[4,3-h] quinazoline derivatives as potent CDK2/Cyclin a inhibitors using 3D-QSAR and docking.	2010-09-28	21152296
Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.	2010-08-01	20615696
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.	2010-07-22	20575555
Intense one- and two-photon excited fluorescent bis(BF2) core complex containing a 1,8-naphthyridine derivative.	2010-07-02	20509633
2-Chloro-7-methyl-12-phenyldibenzo[b,g][1,8]naphthyridin-11(6H)-one.	2010-06-26	21588030
Synthesis, characterization, photoinduced isomerization, and spectroscopic properties of vinyl-1,8-naphthyridine derivatives and their copper(I) complexes.	2010-05-17	20408579
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.	2010-04-22	20307063
Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II.	2010-04-15	20419121
CoMFA and CoMSIA analyses on 4-oxo-1,4-dihydroquinoline and 4-oxo-1,4-dihydro-1,5-, -1,6- and -1,8-naphthyridine derivatives as selective CB2 receptor agonists.	2010-04	19809837
[Molecular geometries and theoretical electronic spectra of four 1,8-naphthyridine derivatives].	2010-03	20496665
2,7-Bis-(trichloro-meth-yl)-1,8-naphthyridine.	2010-02-13	21580380
N'-[(E)-Benzyl-idene]-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide.	2009-11-21	21578871
Anticancer and immunomodulatory activities of novel 1,8-naphthyridine derivatives.	2009-10	19555167
Synthesis and in-vitro antitumour activity of new naphthyridine derivatives on human pancreatic cancer cells.	2009-08	19703350
2,7-Dimethyl-1,8-naphthyridine.	2009-07-04	21583458
Synthesis and cytotoxic activity of 5,6-heteroaromatically annulated pyridine-2,4-diamines.	2009-07-01	19481463
[μ-Bis(5,7-dimethyl-1,8-naphthyridin-2-yl)diazene]bis-[difluoridoboron(III)].	2009-06-24	21582932
2,2',4,4'-Tetra-methyl-7,7'-diazenediylbis(1,8-naphthyridin-1-ium) bis-(perchlorate).	2009-06-06	21582799
1-Ethyl-N'-[(E)-4-hydroxy-benzyl-idene]-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide.	2009-03-25	21582576
7-(2,2-Dimethylpropanamido)-2-methyl-1,8-naphthyridin-1-ium chloride monohydrate.	2009-01-17	21581941
A 1,8-naphthyridine-based fluorescent chemodosimeter for the rapid detection of Zn2+ and Cu2+.	2008-11-20	18954057
Synthesis of binuclear platinum complexes containing the ligands 8-naphthyridine, 2-aminopyridine, and 7-azaindolate. An experimental study of the steric hindrance of the bulky pentafluorophenyl ligands in the synthesis of binuclear complexes.	2008-10-06	18767797
2,2'-Dimethyl-7,7'-(methyl-enediimino)di-1,8-naphthyridin-1-ium bis-(perchlorate).	2008-08-06	21201691
Quantitative structure-activity relationship study on affinity profile of a series of 1,8-naphthyridine antagonists toward bovine adenosine receptors.	2008-06	18569352
Naphthyridine-based helical foldamers and macrocycles: synthesis, cation binding, and supramolecular assemblies.	2008-04-04	18315005
cis,trans-Dicarbonyl-dichlorido[2-(2-pyrid-yl)-1,8-naphthyridine-κN,N]ruthenium(II).	2008-02-06	21201842
Effect of an alkyl amino group on the binding of 1,8-naphthyridines to AP site-containing DNA duplexes.	2008	18776281
One-pot solvent free synthesis and DNA binding studies of thieno[2,3-b]-1,8-naphthyridines.	2008	18080916
7-[4-(5,7-Dimethyl-1,8-naphthyridin-2-yl-oxy)phen-oxy]-2,4-dimethyl-1,8-naphthyridine methanol disolvate.	2007-12-12	21200814
7-Acetyl-amino-2,4-dimethyl-1,8-naphthyridine.	2007-12-06	21200676
Bis(7-amino-2,4-dimethyl-1,8-naphthyridine)dinitratocadmium(II).	2007-12-06	21200626
Dichloridobis(7-amino-2,4-dimethyl-1,8-naphthyridine-κN,N')cobalt(II) methanol disolvate.	2007-12-06	21200493
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists.	2007-12-01	17942307
Synthesis and structure-activity relationships of potent antitumor active quinoline and naphthyridine derivatives.	2007-11	18045063
Photochromism of photoenolizable ketones in quinoline and 1,8-naphthyridine series studied by time-resolved absorption spectroscopy.	2007-03-15	17388272
Oxacalixarenes and oxacyclophanes containing 1,8-naphthyridines: a new class of molecular tweezers with concave-surface functionality.	2007-03-14	17325794
Synthesis and spectral investigations of manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) complexes of new polydentate ligands containing a 1,8-naphthyridine moiety.	2006-12-21	18007404
Effects of anti-inflammatory [1, 2, 4]triazolo[4, 3-a] [1, 8]naphthyridine derivatives on human stimulated PMN and endothelial cells: an in vitro study.	2006-03-28	16569220
1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors.	2005-10-15	16099648
Structure-phototoxicity relationship in Balb/c mice treated with fluoroquinolone derivatives, followed by ultraviolet-A irradiation.	2005-07-04	15917145
Tetrakis(mu(2)-1,8-naphthyridine)-1:2kappa(4)N:N';3:4kappa(4)N:N'-bis(mu(2)-salicylato)-1:4kappa(2)O:O';2:3kappa(2)O:O'-tetrakis(salicylic acid)-1kappaO,2kappaO,3kappaO,4kappaO-tetrasilver(I)(4 Ag-Ag).	2005-06	15930659
Part 3: synthesis and biological evaluation of some analogs of the antitumor agents, 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid, and 2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic acid.	2005-02-15	15670915
Novel inhibitors of bacterial protein synthesis: structure-activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants.	2004-06-21	15149694
Synthesis and structure-activity relationships of 3-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridines as novel antitumor agents.	2004-06-21	15149673
Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives.	2004-06-03	15163184
Synthesis and biological evaluation of 1,8-naphthyridin-4(1H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptors.	2004-04-15	15051060
Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 2.	2004-04-08	15056007
Syntheses and EGFR kinase inhibitory activity of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles.	2004-03-22	15006373
Modeling the syn disposition of nitrogen donors at the active sites of carboxylate-bridged diiron enzymes. Enforcing dinuclearity and kinetic stability with a 1,2-diethynylbenzene-based ligand.	2003-12-29	14686842
Synthesis and beta-blocking activity of (R,S)-(E)-oximeethers of 2,3-dihydro-1,8-naphthyridine and 2,3-dihydrothiopyrano[2,3-b]pyridine: identification of beta 3-antagonists.	2003-11-17	14604653

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:55:28 GMT 2025` Edited by `admin` on `Mon Mar 31 18:55:28 GMT 2025`
Record UNII	043R04VL4M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1,8-PYRIDOPYRIDINE

Preferred Name

English

1,8-NAPHTHYRIDINE

Systematic Name

English

1,8-DIAZANAPHTHALENE

Systematic Name

English

Code System Code Type Description

CHEBI

36628