GLYCOL STEARATE

First approved in 1970

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H40O3
Molecular Weight	328.5298
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCCCCCCCCCCCC(=O)OCCO

InChI

InChIKey=RFVNOJDQRGSOEL-UHFFFAOYSA-N

InChI=1S/C20H40O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(22)23-19-18-21/h21H,2-19H2,1H3

HIDE SMILES / InChI

Molecular Formula	C20H40O3
Molecular Weight	328.5298
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ewg.org/skindeep/ingredient/702701/GLYCOL_STEARATE/
Curator's Comment: description was created based on several sources, including https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@rn+@rel+9004-99-3 | http://online.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/pr237.PDF

Glycol stearate is the ester of ethylene glycol and stearic acid, a naturally occurring fatty acid. In cosmetic and personal care products it functions as a surfactant - cleansing agent in skin creams, conditioners, shampoos, body cleansers and soapless detergents. Glycol stearate is considered not to be a toxic hazard in the quantities available through normal exposure or package size. It is also can be used as inactive ingredient in medications.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Erythema 17 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208552s000lbl.pdf	Inactive ingredient		Approved 8429	RHOFADE Approved Use RHOFADE is indicated for the topical treatment of persistent facial erythema associated with rosacea in adults. Launch Date 1.48461126E12

PubMed

Title	Date	PubMed
The influence of Myrj 59 on the solubility, toxicity and activity of amphotericin B.	1991 May	1680169
Influence of the dissolution rate on the collapse and shedding behavior of monostearin/monopalmitin-rich coated microbubbles.	2008 Sep 16	18717575

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:12:18 UTC 2023` Edited by `admin` on `Fri Dec 15 15:12:18 UTC 2023`
Record UNII	0324G66D0E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GLYCOL STEARATE

Official Name

English

ETHYLENE GLYCOL MONOSTEARATE

Systematic Name

English

GLYCOL STEARATE [INCI]

Common Name

English

2-HYDROXYETHYL STEARATE

Systematic Name

English

STEARIC ACID, 2-HYDROXYETHYL ESTER

Common Name

English

Ethylene glycol monostearate [WHO-DD]

Common Name

English

GLYCOL STEARATE [VANDF]

Common Name

English

OCTADECANOIC ACID, 2-HYDROXYETHYL ESTER

Common Name

English

GLYCOL STEARATE [II]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C83486